Necrotizing soft tissue infection of the breast: Case report and literature review
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2012-08-01
Autores
Vieira, René Aloisio Da Costa
Matthes, Angelo Gustavo Zucca [UNESP]
Michelli, Rodrigo Augusto Depieri
Ribeiro, Gustavo Henrique Fabri Pereira
Haikel, Raphael Luiz
Viana, Cristiano Ribeiro
Castro, Paulo de Tarso Oliveira
Uemura, Gilberto [UNESP]
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Resumo
Background: Necrotizing soft tissue infection (NSTI) is characterized by progressive infectious gangrene of the skin and subcutaneous tissue. Its treatment involves intensive care, broad-spectrum antibiotic therapy, and full debridement. Methods: We present two cases of NSTI of the breast, adding these cases to the 14 described in the literature, reviewing the characteristics and evolution of all cases. Case Report: On the fourth day after mastectomy, a 59-year-old woman with ulcerated breast cancer developed Type I NSTI caused by Pseudomonas aeruginosa, which had a favorable evolution after debridement and broad-spectrum antibiotics. The second patient was a 57-year-old woman submitted to a mastectomy and axillary dissection, who had recurrent seromas. On the 32nd post-operative day, after a seroma puncture, she developed Type II NSTI caused by β-hemolytic streptococci. She developed sepsis and died on the tenth day after debridement, intensive care, and broad-spectrum antibiotics. The cases are the first description of breast NSTI after mammary seroma aspiration and the first report of this condition caused by P. aeruginosa. Conclusion: Necrotizing soft tissue infection is rare in breast tissue. It frequently is of Type II, occurring mainly after procedures in patients with breast cancer. The surgeon's participation in controlling the focus of the infection is of fundamental importance, and just as important are broad-spectrum antibiotic therapy and support measures, such as maintenance of volume, correction of electrolytic disorders, and treatment of sepsis and septic shock. Once the infection has been brought under control, skin grafting or soft tissue flaps can be considered. The mortality rate in breast NSTI is 18.7%, all deaths being in patients with the fulminant Type II form. Surgical oncologists need to be alert to the possibility of this rare condition. © 2012, Mary Ann Liebert, Inc.
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amikacin, amoxicillin, ampicillin, cefazolin, cefepime, ceftriaxone, chlormidazole, clavulanic acid, clindamycin, ertapenem, gentamicin, linezolid, metronidazole, tazobactam, tobramycin, vancomycin, adult, antibiotic therapy, aspiration, beta hemolytic Streptococcus, breast carcinoma, cancer adjuvant therapy, case report, debridement, electrolyte disturbance, female, human, infection control, intensive care, mastectomy, mastitis, medical specialist, mortality, postoperative care, priority journal, Pseudomonas aeruginosa, recurrent disease, sepsis, septic shock, seroma, skin graft, soft tissue infection, tissue flap, Bacteremia, Breast Neoplasms, Fasciitis, Necrotizing, Fatal Outcome, Female, Humans, Mastectomy, Middle Aged, Pseudomonas Infections, Soft Tissue Infections, Streptococcus pyogenes
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Surgical Infections, v. 13, n. 4, p. 270-275, 2012.