• Pharmaceutical Biotechnology 

  Roque-Borda, Cesar Augusto ; Pavan, Fernando Rogério ; Meneguin, Andréía Bagliotti (Life, 2022) [Editorial]

• Beta-lactam resistance and the effectiveness of antimicrobial peptides against KPC-producing bacteria 

  da Costa de Souza, Guilherme ; Roque-Borda, Cesar Augusto ; Pavan, Fernando R. (Drug Development Research, 2022) [Resenha]

  Bacterial resistance is a problem that is giving serious cause for concern because bacterial strains such as Acinetobacter baumannii and Pseudomonas aeruginosa are difficult to treat and highly opportunistic. These bacteria ...

• In Vitro Skin Co-Delivery and Antibacterial Properties of Chitosan-Based Microparticles Containing Ascorbic Acid and Nicotinamide 

  Di Filippo, Leonardo Delello ; Duarte, Jonatas Lobato ; Roque-Borda, Cesar Augusto ; Pavan, Fernando Rogério ; Meneguin, Andreia Bagliotti ; Chorilli, Marlus ; Melero, Ana; Guillot, Antonio José; Spagnol, Caroline Magnani ; Correa, Marcos Antônio (Life, 2022) [Artigo]

  Vitamins are widely found in nature, for example, in plants and fruits. Ascorbic acid and nicotinamide are examples of these compounds that have potent antioxidant properties, besides stimulating collagen production and ...

• Synthesis and in vitro evaluation of antimycobacterial activity of two palladium(II) complexes based on 5-alkyl-1,3,4-oxadiazol-2(3H)-thione derivatives 

  Souza, Wesley Almeida; Demarqui, Fernanda Manaia ; de Almeida, Angelina Maria; Silva, Raphael Tristão Cruvinel; Alves, Douglas Alexsander; Araújo, Thaise Gonçalves; Resende, Jackson Antonio Lamounier Camargos; Pavan, Fernando Rogério ; Santos, Hélio Ferreira Dos; de Almeida, Mauro Vieira et al. (Journal of Molecular Structure, 2022) [Artigo]

  In this work, two palladium(II) complexes, namely, [Pd(L1)2(phen)] 1 and [Pd(L2)2(phen)] 2 (L1 = 5-heptyl-1,3,4-oxadiazole-2-(3H)-thione, L2 = 5-nonyl-1,3,4-oxadiazole-2-(3H)-thione and phen = 1,10-phenanthroline), were ...

• Cetyltrimethylammonium bromide in the synthesis of mesoporous silica nanoparticles: General aspects and in vitro toxicity 

  Carvalho, Gabriela Corrêa ; Marena, Gabriel Davi ; Karnopp, Juliana Camila Fischer; Jorge, Juliana; Sábio, Rafael Miguel ; Martines, Marco Antonio Utrera; Bauab, Taís Maria ; Chorilli, Marlus (Advances in Colloid and Interface Science, 2022) [Resenha]

  Pharmaceutical nanotechnology has become a trend with incalculable advantages in the applicability of systems in the controlled, safe and effective release of drugs. Among the nanotechnological nanoparticles, the mesoporous ...

• Photodynamic therapy-mediated hypericin-loaded nanostructured lipid carriers against vulvovaginal candidiasis 

  Sato, Mariana Rillo ; Oshiro-Junior, João Augusto; Rodero, Camila Fernanda ; Boni, Fernanda Isadora ; Araújo, Victor Hugo Sousa ; Bauab, Taís Maria ; Nicholas, Dean; Callan, John F.; Chorilli, Marlus (Journal of Medical Mycology, 2022) [Artigo]

  Introduction and Aim: The indiscriminate use and adverse effects of the main conventional antifungal agents compromise the effectiveness of treating vulvovaginal candidiasis (VVC), mainly caused by the species Candida ...

• Functionalized lipid-based drug delivery nanosystems for the treatment of human infectious diseases 

  Almeida Furquim de Camargo, Bruna ; Fonseca-Santos, Bruno; Gonçalves Carvalho, Suzana ; Corrêa Carvalho, Gabriela ; Delello Di Filippo, Leonardo ; Sousa Araújo, Victor Hugo ; Lobato Duarte, Jonatas ; Polli Silvestre, Amanda Letícia ; Bauab, Taís Maria ; Chorilli, Marlus (Critical Reviews in Microbiology, 2022) [Resenha]

  Infectious diseases are still public health problems. Microorganisms such as fungi, bacteria, viruses, and parasites are the main causing agents related to these diseases. In this context, the search for new effective ...

• XAC4296 Is a Multifunctional and Exclusive Xanthomonadaceae Gene Containing a Fusion of Lytic Transglycosylase and Epimerase Domains 

  de Oliveira, Amanda C. P. ; Ferreira, Rafael M. ; Ferro, Maria Inês T. ; Ferro, Jesus A. ; Zamuner, Caio ; Ferreira, Henrique ; Varani, Alessandro M. (Microorganisms, 2022) [Artigo]

  Microorganisms have a limited and highly adaptable repertoire of genes capable of encoding proteins containing single or variable multidomains. The phytopathogenic bacteria Xanthomonas citri subsp. citri (X. citri) ...

• Tapping into the antitubercular potential of 2,5-dimethylpyrroles: A structure-activity relationship interrogation 

  Semenya, Dorothy; Touitou, Meir; Masci, Domiziana; Ribeiro, Camila Maringolo ; Pavan, Fernando Rogerio ; Dos Santos Fernandes, Guilherme Felipe; Gianibbi, Beatrice; Manetti, Fabrizio; Castagnolo, Daniele (European Journal of Medicinal Chemistry, 2022) [Artigo]

  An exploration of the chemical space around a 2,5-dimethylpyrrole scaffold of antitubercular hit compound 1 has led to the identification of new derivatives active against Mycobacterium tuberculosis and multidrug-resistant ...

• RIP2 Contributes to Expanded CD4+ T Cell IFN-g Production during Efferocytosis of Streptococcus pneumoniae–Infected Apoptotic Cells 

  Niño-Castaño, Victoria Eugenia ; de Aquino Penteado, Letícia ; Silva-Pereira, Ludmilla ; Bazzano, Júlia Miranda Ribeiro ; Orlando, Allan Botinhon ; Salina, Ana Carolina Guerta ; Dejani, Naiara Naiana; Bonato, Vânia L.D.; Serezani, C. Henrique; Medeiros, Alexandra Ivo (ImmunoHorizons, 2022) [Artigo]

  Apoptotic cell clearance by professional and nonprofessional phagocytes in the process of efferocytosis is critical to preserve tissue homeostasis. Uptake of apoptotic cells by dendritic cells generates regulatory T cells ...

• Development and characterization of an amphotericin B - loaded nanoemulsion applied to Candida auris biofilms control 

  Marena, Gabriel Davi ; Ramos, Matheus Aparecido dos Santos ; Carvalho, Gabriela Corrêa ; de Lima, Laura Caminitti ; Nascimento, André Luiz Carneiro Soares do ; Sábio, Rafael Miguel ; Rodero, Camila Fernanda ; Spósito, Larissa ; Bauab, Tais Maria ; Chorilli, Marlus (Journal of Drug Delivery Science and Technology, 2022) [Artigo]

  Nanoemulsions (NE) belong to the class of emulsions widely used in the scientific field in order to improve drugs bioavailability and selectivity, especially in the control of microbial resistance. Among the resistant ...

• Investigating method effects associated with the wording direction of items of the Social Physique Anxiety Scale 

  da Silva, Wanderson Roberto ; Donofre, Giovanna Soler ; Neves, Angela Nogueira; Marôco, João; Teixeira, Patrícia Angélica ; Campos, Juliana Alvares Duarte Bonini (Eating and Weight Disorders, 2022) [Artigo]

  Purpose: The use of psychometric instruments to measure latent concepts is common. The development of these instruments usually involves mechanisms to reduce response bias, such as the inclusion of reversed items. The aim ...

• Natural product-based nanomedicine applied to fungal infection treatment: A review of the last 4 years 

  Marena, Gabriel Davi ; Ramos, Matheus Aparecido dos Santos ; Carvalho, Gabriela Corrêa ; Junior, José Alberto Paris; Resende, Flávia Aparecida; Corrêa, Ione ; Ono, Gabriela Yuki Bressanim ; Sousa Araujo, Victor Hugo ; de Camargo, Bruna Almeida Furquim ; Bauab, Tais Maria et al. (Phytotherapy Research, 2022) [Resenha]

  Fungal infections are one of the main public health problems, especially in immunocompromised patients, nosocomial environments, patients with chronic diseases, and transplant recipients. These diseases are increasingly ...

• VNTR Polymorphism in Intron 4 of the eNOS Gene and the Risk of Gastrointestinal Bleeding: A Case-control Study 

  Forgerini, Marcela ; Urbano, Gustavo; de Nadai, Tales Rubens; Zanelli, Cleslei Fernando ; Valentini, Sandro Roberto ; Mastroianni, Patrícia de Carvalho (Journal of Gastrointestinal and Liver Diseases, 2022) [Artigo]

  Background & Aims: Considering the lack of knowledge regarding the influence of the variable number of repeats of 27 pb in intron 4 (4b/4a VNTR-rs61722009) of the endothelial nitric oxide synthase (eNOS) on the drug response, ...

• Self-perception of orofacial appearance: Brazil–Finland cross-national study 

  Campos, Lucas Arrais ; Campos, Juliana Alvares Duarte Bonini ; Kämäräinen, Minna; Silvola, Anna-Sofia; Marôco, João; Peltomäki, Timo (Acta Odontologica Scandinavica, 2022) [Artigo]

  Objective: (i) To study the measurement invariance of Orofacial Esthetic Scale (OES) and Psychosocial Impact of Dental Aesthetics Questionnaire (PIDAQ), (ii) to compare the perception of orofacial appearance (OA) and (iii) ...

• Psychometric investigation of the Attention to Body Shape Scale in Brazilian adults 

  Teixeira, Patrícia Angélica ; Silva, Wanderson Roberto da ; Campos, Lucas Arrais de ; Marôco, João; Campos, Juliana Alvares Duarte Bonini (Ciencia e Saude Coletiva, 2022) [Artigo]

  The objectives of the study were to develop a Portuguese version of Attention to Body Shape Scale (ABS), estimate the psychometric properties of the ABS for Brazilian data, and compare the ABS scores between the sexes and ...

• Biological Properties of Extracts from Byrsonima Species in Microemulsions 

  Lima Neto, José de Sousa ; Marena, Gabriel Davi; Girotto, Luiza; Magorpo, Vanessa; Ramos, Matheus Aparecido dos Santos ; Silva, Patrícia Bento da ; Chorilli, Marlus ; Bauab, Tais Maria ; Resende, Flávia Aparecida (Revista Brasileira de Farmacognosia, 2022) [Artigo]

  The Byrsonima genus, Malpighiaceae, represents a rich source of phenolic compounds with proven pharmacological properties (antiulcerogenic, antimicrobial, antimutagenic, and antioxidant activities). In this context, the ...

• Potential cannabidiol (CBD) repurposing as antibacterial and promising therapy of CBD plus polymyxin B (PB) against PB-resistant gram-negative bacilli 

  Abichabki, Nathália; Zacharias, Luísa V.; Moreira, Natália C.; Bellissimo-Rodrigues, Fernando; Moreira, Fernanda L.; Benzi, Jhohann R. L.; Ogasawara, Tânia M. C.; Ferreira, Joseane C.; Ribeiro, Camila M. ; Pavan, Fernando R. et al. (Scientific Reports, 2022) [Artigo]

  This study aimed to assess the ultrapure cannabidiol (CBD) antibacterial activity and to investigate the antibacterial activity of the combination CBD + polymyxin B (PB) against Gram-negative (GN) bacteria, including ...

• Non-Mutagenic ruthenium(II) Based Complexes With Naphthoquinones as New Antitumor Agents Against Prostate Metastatic Carcinoma 

  De Grandis, Rone A.; Ulbrich, Matheus R.; Costa, Analu R.; Pavan, Fernando R. ; Nogueira, Flavia A. Resende; Batista, Alzir A. (Environmental And Molecular Mutagenesis, 2022) [Resumo]

• Transcriptomics Applied to the Study of Chagas Disease Vectors 

  Borsatto, Kelly Cristine ; Coronado, Monika Aparecida; Galvao, Cleber; Arni, Raghuvir Krishnaswamy ; Alevi, Kaio Cesar Chaboli (American Journal Of Tropical Medicine And Hygiene, 2022) [Resenha]

  Chagas disease is a neglected disease caused by the protozoan Trypanosoma cruzi, and is transmitted mainly by the feces of contaminated triatomines. Knowledge of the biological, ecological, behavioral, genetic, taxonomic, ...

View more