• Mucoadhesive In Situ Gelling Liquid Crystalline Precursor System to Improve the Vaginal Administration of Drugs 

  de Araújo, Patricia Rocha ; Calixto, Giovana Maria Fioramonti ; da Silva, Isabel Cristiane ; de Paula Zago, Lucas Henrique ; Oshiro Junior, João Augusto; Pavan, Fernando Rogério ; Ribeiro, Anderson Orzari; Fontana, Carla Raquel ; Chorilli, Marlus (AAPS PharmSciTech, 2019) [Artigo]

  The vaginal mucosa is a very promising route for drug administration due to its high permeability and the possibility to bypass first pass metabolism; however, current vaginal dosage forms present low retention times due ...

• Three new records of the genus Lutzomyia of the subgenus Helcocyrtomyia (Diptera: Psychodidae: Phlebotominae) from Southwestern Brazilian Amazonia 

  Ortiz, Dennys Ghenry Samillan; Pinto, Mara Cristina ; Cesario, Manuel; Galati, Eunice Aparecida Bianchi; Molina, Silvia Maria Guerra; Borges, Diones Antonio (Acta Tropica, 2019) [Artigo]

  The sand fly phlebotomine fauna of the Brazilian municipality of Assis Brasil, Acre was sampled between April 2013 and March 2014 using modified CDC light traps. A total of 22,334 sand flies were collected, 41 of them ...

• New ternary iron(iii) aminobisphenolate hydroxyquinoline complexes as potential therapeutic agents 

  Matos, Cristina P.; Yildizhan, Yasemin; Adiguzel, Zelal; Pavan, Fernando R. ; Campos, Débora L. ; Pessoa, João Costa; Ferreira, Liliana P.; Tomaz, Ana Isabel; Correia, Isabel; Acilan, Ceyda (Dalton Transactions, 2019) [Artigo]

  In the quest for therapeutic iron-based metallodrugs, two new mixed-ligand iron(iii) complexes bearing the tripodal aminobisphenolate ligand N,N-bis(3,5-dimethyl-2-hydroxybenzyl)-N-(2-pyridylmethyl)amine (H2L) and ...

• New records of Mepraia (Hemiptera, Reduviidae, Triatominae) in Chile 

  Rosa, João Aristeu da ; de Oliveira, Jader ; Laserre, Daniel Alfredo Frías (Journal of Vector Ecology, 2019) [Artigo]

• May iron(III) complexes containing phenanthroline derivatives as ligands be prospective anticancer agents? 

  Matos, Cristina P.; Adiguzel, Zelal; Yildizhan, Yasemin; Cevatemre, Buse; Onder, Tugba Bagci; Cevik, Ozge; Nunes, Patrique; Ferreira, Liliana P.; Carvalho, Maria Deus; Campos, Débora L. et al. (European Journal of Medicinal Chemistry, 2019) [Artigo]

  We report the design, synthesis and biological studies on a group of mixed ligand Fe(III) complexes as anti-cancer drug candidates, namely their interaction with DNA, cytotoxicity and mechanism(s) of action. The aim is to ...

• Bovine fasciolisis in São Paulo state, Brazil 

  Mendes, Tiago Manuel Fernandes; Filho, David Vilas Boas; Bataglioli, Acácio Santo; do Prado, Angelo Pires; Madi, Rubens Riscala; Ueta, Marlene Tiduko; Pinto, Mara Cristina ; Allegretti, Silmara Marques (Veterinary Parasitology: Regional Studies and Reports, 2019) [Artigo]

  Fasciolosis is a zoonotic disease with a worldwide distribution caused by Fasciola hepatica, which leads to severe economic losses in cattle such as reducing meat and milk production, livers condemnation, growth retardation ...

• Esterification of the free carboxylic group from the lutidinic acid ligand as a tool to improve the cytotoxicity of Ru(ii) complexes 

  Honorato, João; Colina-Vegas, Legna; Correa, Rodrigo S.; Guedes, Adriana P.M.; Miyata, Marcelo ; Pavan, Fernando R. ; Ellena, Javier; Batista, Alzir A. (Inorganic Chemistry Frontiers, 2019) [Artigo]

  In this study, we report on the selective esterification of the carboxyl group in a coordinated ligand based on the Fischer reaction. The new [Ru(N-O)(bipy)(dppb)]PF 6 complex 1 was used as a precursor to obtain the ester ...

• Byrsonima intermedia A. Juss partitions promote gastroprotection against peptic ulcers and improve healing through antioxidant and anti-inflammatory activities 

  de Cássia dos Santos, Raquel ; Bonamin, Flavia ; Périco, Larissa Lucena ; Rodrigues, Vinícius Peixoto ; Zanatta, Ana Caroline ; Rodrigues, Clenilson Martins; Sannomiya, Miriam; dos Santos Ramos, Matheus Aparecido ; Bonifácio, Bruna Vidal ; Bauab, Taís Maria et al. (Biomedicine and Pharmacotherapy, 2019) [Artigo]

  Byrsonima intermedia is a species of bush popularly used to treat gastrointestinal disorders, such as gastric ulcers, gastritis, and diarrhea. Previous studies have revealed that the methanolic crude extract of B. intermedia ...

• An effective mosquito-repellent topical product from liquid crystal-based tea tree oil 

  Fonseca-Santos, Bruno ; Del Nero Pacheco, Camila ; Pinto, Mara Cristina ; Chorilli, Marlus (Industrial Crops and Products, 2019) [Artigo]

  Diseases such as dengue, malaria, yellow fever and others transmitted by culicides determine high rates of morbidity and mortality, especially in tropical countries. An alternative to avoid bites is the use of repellents. ...

• Cytotaxonomy of trypanosoma cruzi (Chagas, 1909): Differentiation of T. Cruzi I (TcI) and T. Cruzi II (TcII) genotypes using cytogenetic markers 

  De Oliveira, Ana Beatriz Bortolozo ; Ribeiro, Aline Rimoldi; Madeira, Fernanda Fernandez ; Cesaretto, Natália Regina ; Da Rosa, João Aristeu ; De Azeredo-Oliveira, Maria Tercília Vilela ; Chaboli Alevi, Kaio Cesar (American Journal of Tropical Medicine and Hygiene, 2019) [Artigo]

  Chagas disease is a public health problem caused by the Trypanosoma cruzi, and the T. cruzi I (TcI) and T. cruzi II (TcII) groups are considered important genotypes from the clinical point of view. Currently, the groups ...

• Bacterial cellulose membrane functionalized with hydroxiapatite and anti-bone morphogenetic protein 2: A promising material for bone regeneration 

  Coelho, Fernanda ; Cavicchioli, Maurício ; Specian, Sybele Saska ; Scarel-Caminaga, Raquel Mantuaneli ; de Aquino Penteado, Letícia ; de Medeiros, Alexandra Ivo ; de Lima Ribeiro, Sidney José ; de Oliveira Capote, Ticiana Sidorenko (PLoS ONE, 2019) [Artigo]

  Bone tissue engineering seeks to adequately restore functions related to physical and biological properties, aiming at a repair process similar to natural bone. The use of compatible biopolymers, such as bacterial cellulose ...

• CytoKey: Identification key for the chagas disease vectors of the Largest Brazilian Urban Center (São Paulo State), based on cytogenetic data 

  Borsatto, Kelly Cristine ; Dos Reis, Yago Visinho ; Garcia, Ariane Cristina Caris ; De Sousa, Paulo Sergio ; De Azeredo-Oliveira, Maria Tercília Vilela ; Alevi, Kaio Cesar Chaboli (American Journal of Tropical Medicine and Hygiene, 2019) [Artigo]

  Chagas disease is caused by the protozoan Trypanosoma cruzi. This disease is distributed in 21 Latin American countries, where it is mostly vector-borne. In Brazil, there are 68 triatomine species. To date, the epidemiological ...

• Antibacterial activity of 3,3′-dihydroxycurcumin (DHC) is associated with membrane perturbation 

  Polaquini, Carlos R. ; Morão, Luana G. ; Nazaré, Ana C. ; Torrezan, Guilherme S. ; Dilarri, Guilherme ; Cavalca, Lúcia B. ; Campos, Débora L. ; Silva, Isabel C. ; Pereira, Jessé A. ; Scheffers, Dirk-Jan et al. (Bioorganic Chemistry, 2019) [Artigo]

  Curcumin is a plant diphenylheptanoid and has been investigated for its antibacterial activity. However, the therapeutic uses of this compound are limited due to its chemical instability. In this work, we evaluated the ...

• Acidic and hepatic derivatives of bioactive clerodane diterpenes casearins J and O 

  Oda, Fernando Bombarda ; Crevelin, Eduardo José; Crotti, Antônio Eduardo Miller; Orlando, Allan Botinhon ; de Medeiros, Alexandra Ivo ; Nogueira, Flávia Aparecida Resende; dos Santos, André Gonzaga (Fitoterapia, 2019) [Artigo]

  Clerodane diterpenes from Casearia sylvestris are antiulcerogenic and anti-inflammatory. The finding that they may undergo acid degradation or hepatic metabolization led to an investigation of their degradation products. ...

• In-situ gelling liquid crystal mucoadhesive vehicle for curcumin buccal administration and its potential application in the treatment of oral candidiasis 

  Fonseca-Santos, Bruno ; Bonifácio, Bruna Vidal ; Baub, Taís Maria ; Gremião, Maria Palmira Daflon ; Chorilli, Marlus (Journal of Biomedical Nanotechnology, 2019) [Artigo]

  The treatments of oral candidiasis involve azole-based antifungals; however, the fungal resistance of these drug compounds has been detected in worldwide. Therefore, the discovery of new molecules from natural sources, ...

• Improving the cost effectiveness of enhanced green fluorescent protein production using recombinant Escherichia coli BL21 (DE3): Decreasing the expression inducer concentration 

  Lopes, Camila ; dos Santos, Nathalia Vieira ; Dupont, Jana ; Pedrolli, Danielle Biscaro ; Valentini, Sandro Roberto ; de Carvalho Santos-Ebinuma, Valéria ; Pereira, Jorge Fernando Brandão (Biotechnology and Applied Biochemistry, 2019) [Artigo]

  Green fluorescent protein (GFP) is a globular protein used as biosensor and biomarker in medical and industrial fields. However, due to the expensive production costs of expressing proteins using high-cost inducers like ...

• Genetic structure of brazilian populations of triatoma sordida (stal, 1859) (hemiptera, triatominae) by means of chromosomal markers 

  Madeira, Fernanda Fernandez ; Dos Reis, Yago Visinho ; De Freitas Bittinelli, Isadora ; Delgado, Luiza Maria Grzyb ; De Oliveira, Jader ; Mendonça, Vagner José; Moreira, Felipe Ferraz Figueiredo; De Azeredo-Oliveira, Maria Tercília Vilela ; Da Rosa, João Aristeu ; Alevi, Kaio Cesar Chaboli (American Journal of Tropical Medicine and Hygiene, 2019) [Artigo]

  Triatoma sordida is among the main Brazilian species considered as Chagas disease vectors. The genetic studies are directed mainly to phylogenetic questions because this species possibly have suffered cryptic speciation. ...

• Influence of Leishmania (Viannia) braziliensis infection on the attractiveness of BALB/c mice to Nyssomyia neivai (Diptera: Psychodidae) 

  da Rocha Silva, Flávia Benini ; Miguel, Danilo Ciccone; Machado, Vicente Estevam ; Oliveira, Wanderson Henrique Cruz ; Goulart, Thais Marchi; Tosta, Christiann Davis; Pinheiro, Hildete Prisco; Pinto, Mara Cristina (PLoS ONE, 2019) [Artigo]

  Background Phlebotomine sand flies are vectors for several pathogens, with Leishmania being the most important. In Brazil, the main aetiological agent of American cutaneous leishmaniasis (ACL) is Leishmania (Viannia) ...

• Intravaginal delivery of syngonanthus nitens (Bong.) Ruhland fraction based on a nanoemulsion system applied to vulvovaginal candidiasis treatment 

  dos Santos Ramos, Matheus Aparecido ; Da Silva, Patrícia Bento ; De Toledo, Luciani Gaspar ; Oda, Fernando Bombarda ; Da Silva, Isabel Cristiane ; dos Santos, Lourdes Campaner ; dos Santos, André Gonzaga ; De Almeida, Margarete Teresa Gottardo; Pavan, Fernando Rogério ; Chorilli, Marlus et al. (Journal of Biomedical Nanotechnology, 2019) [Artigo]

  In this study, was evaluated the chemical composition of a fraction from Syngonanthus nitens extract and its antimicrobial potential unloaded (Fr3) and loaded (F9Fr3) into a nanoemulsion (F9) composed of cholesterol as the ...

• Exploiting the furo[2,3-b]pyridine core against multidrug-resistant Mycobacterium tuberculosis 

  Fumagalli, Fernando; de Melo, Shaiani Maria Gil; Ribeiro, Camila Maríngolo ; Solcia, Mariana Cristina ; Pavan, Fernando Rogério ; da Silva Emery, Flavio (Bioorganic and Medicinal Chemistry Letters, 2019) [Artigo]

  Identification of new antibiotics suitable for the treatment of tuberculosis is required. In addition to selectivity, it is necessary to find new antibiotics that are effective when the tuberculous mycobacteria are resistant ...

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