RSS 1.0Artigos - Ciências Biológicas - FCFAR
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Antimicrobial Peptides as an Alternative for the Eradication of Bacterial Biofilms of Multi-Drug Resistant Bacteria
de Pontes, Janaína Teixeira Costa
; Borges, Anna Beatriz Toledo ; Roque-Borda, Cesar Augusto ; Pavan, Fernando Rogério (Pharmaceutics, 2022) [Resenha]
Bacterial resistance is an emergency public health problem worldwide, compounded by the ability of bacteria to form biofilms, mainly in seriously ill hospitalized patients. The World Health Organization has published a ... -
Immature instars of three species of Rhodnius Stål, 1859 (Hemiptera, Reduviidae, Triatominae): morphology, morphometry, and taxonomic implications
Lázari Cacini, Gustavo; ; ; ; Olaia, Nicoly ; Pinto, Mara Cristina ; da Rosa, João Aristeu (Parasites and Vectors, 2022) [Artigo]
Background: Among the 18 genera of the Triatominae subfamily, three stand out for their diversity and epidemiological importance: Triatoma, Panstrongylus, and Rhodnius. Rhodnius includes 21 species that can transmit ... -
Cyrhetrenyl and cymantrenyl N-acylhydrazone complexes based on isoniazid: Synthesis, characterization, X-ray crystal structures and antitubercular activity evaluation
; ; ; ; Pavan, Fernando Rogério; Demarqui, Fernanda Manaia ; ; ; (Journal of Organometallic Chemistry, 2022) [Artigo]
Four organometallic N-acylhydrazones of the general formulae [M{(η5-C5H4)-CH[dbnd]N[sbnd]NH[sbnd]C(O)-(C5H4[sbnd]N)}(CO)3] [(with M = Re (5a) or Mn (6a)] and [M{(η5-C5H4)-C(Me)=N[sbnd]NH[sbnd]C(O)-(C5H4[sbnd]N)}(CO)3] ... -
HPMCAS-Coated Alginate Microparticles Loaded with Ctx(Ile21)-Ha as a Promising Antimicrobial Agent against Salmonella Enteritidis in a Chicken Infection Model
Roque-Borda, Cesar Augusto; Souza Saraiva, Mauro de Mesquita ; Monte, Daniel F. M. ; Rodrigues Alves, Lucas Bocchini ; de Almeida, Adriana Maria ; Ferreira, Taísa Santiago ; de Lima, Túlio Spina ; Benevides, Valdinete Pereira ; Cabrera, Julia Memrava ; et al. (ACS Infectious Diseases, 2022) [Artigo]
Salmonella enterica subsp. enterica serovar Enteritidis (S. Enteritidis) in poultry is most often transmitted by the fecal-oral route, which can be attributed to high population density. Upon encountering the innate immune ... -
Antibacterial action and target mechanisms of zinc oxide nanoparticles against bacterial pathogens
Mendes, Carolina Rosai; Dilarri, Guilherme ; Forsan, Carolina Froes ; Sapata, Vinícius de Moraes Ruy ; Lopes, Paulo Renato Matos ; ; Montagnolli, Renato Nallin ; Ferreira, Henrique ; Bidoia, Ederio Dino (Scientific Reports, 2022) [Artigo]
Zinc oxide nanoparticles (ZnO NPs) are one of the most widely used nanoparticulate materials due to their antimicrobial properties, but their main mechanism of action (MOA) has not been fully elucidated. This study ... -
Recent advancement in drug development of nitro(NO2)-heterocyclic compounds as lead scaffolds for the treatment of Mycobacterium tuberculosis
; Pavan, Fernando Rogério (Drug Development Research, 2022) [Resenha]
Tuberculosis (TB) is an infectious disease caused predominantly by Mycobacterium tuberculosis (Mtb). It was responsible for approximately 1.4 million deaths worldwide in 2019. The lack of new drugs to treat drug-resistant ... -
Checklist and phenetics studies of nymphs of two species of triatomines: Triatoma lenti Sherlock & Serafim, 1967 and Triatoma sherlocki Papa, Jurberg, Carcavallo, Cerqueira, Barata, 2002 (Hemiptera: Reduviidae: Triatominae)
Rosseto, Leandro Augusto; ; ; ; ; Rosa, João Aristeu Da (Revista da Sociedade Brasileira de Medicina Tropical, 2021) [Artigo]
INTRODUCTION: Triatoma lenti and Triatoma sherlocki are endemic species of the State of Bahia, located in northeastern Brazil, where they have records of domiciliation in the human environment. In view of the epidemiological ... -
An overview of sulfonamide-based conjugates: Recent advances for tuberculosis treatment
; Pavan, Fernando Rogério (Drug Development Research, 2022) [Resenha]
In 2019, tuberculosis (TB) caused approximately 1.4 million deaths around the world. TB is an infectious respiratory disease mainly caused by Mycobacterium tuberculosis. The lack of new drugs to treat drug-resistant strains ... -
Isolation and agricultural potential of penicillic acid against citrus canker
Vieira, Gabrielle; ; ; Sette, Lara D. ; Ferreira, Henrique ; Sass, Daiane C. (Journal of Applied Microbiology, 2022) [Artigo]
Aims: The control of Xanthomonas citri subsp. citri (X. citri), causal agent of citrus canker, relies heavily on integrated agricultural practices involving the use of copper-based chemicals. Considering the need for ... -
Structural Rigidification of N-Aryl-pyrroles into Indoles Active against Intracellular and Drug-Resistant Mycobacteria
; ; Ribeiro, Camila Maringolo; Pavan, Fernando Rogerio ; ; ; ; ; ; et al. (ACS Medicinal Chemistry Letters, 2022) [Artigo]
A series of indolyl-3-methyleneamines incorporating lipophilic side chains were designed through a structural rigidification approach and synthesized for investigation as new chemical entities against Mycobacterium ... -
New silver(I) phosphino complexes: Evaluation of their potential as prospective agents against Mycobacterium tuberculosis
; ; Manieri, Karyn Fernanda; Pavan, Fernando R. ; ; (Journal of Inorganic Biochemistry, 2022) [Artigo]
Despite being a preventable and curable disease, Tuberculosis (TB) is the world's top infectious killer. Development of new drugs is urgently needed. In this work, the synthesis and characterization of new silver(I) ... -
In vivo study of hypericin-loaded poloxamer-based mucoadhesive in situ gelling liquid crystalline precursor system in a mice model of vulvovaginal candidiasis
De Araújo, Patricia Rocha; Calixto, Giovana Maria Fioramonti ; Araújo, Victor Hugo Sousa ; Sato, Mariana Rillo ; Rodero, Camila Fernanda ; ; Bauab, Taís Maria ; Chorilli, Marlus (Medical Mycology, 2021) [Artigo]
The present study reports the performance of the pigment hypericin (HYP)-loaded poloxamer-based mucoadhesive in situ gelling liquid crystalline precursor system (LCPS) for the treatment of vulvovaginal candidiasis (VVC) ... -
GC-TOF/MS-based metabolomics analysis to investigate the changes driven by N-Acetylcysteine in the plant-pathogen Xanthomonas citri subsp. citri
; ; Saldanha, Luiz Leonardo; Ferreira, Henrique ; ; ; (Scientific Reports, 2021) [Artigo]
N-Acetylcysteine (NAC) is an antioxidant, anti-adhesive, and antimicrobial compound. Even though there is much information regarding the role of NAC as an antioxidant and anti-adhesive agent, little is known about its ... -
Syzygium aromaticum (clove) essential oil: An alternative for the sanitization of citrus fruit in packinghouses
Soraggi Battagin, Tiago; Nicolas Caccalano, Mario ; Dilarri, Guilherme ; Felipe Cavicchia Zamuner, Caio ; Alleoni, Natália ; Leonardo Saldanha, Luiz ; Bacci, Maurício ; Ferreira, Henrique (Journal of Food Processing and Preservation, 2021) [Artigo]
Citrus canker is a quarentenary disease caused by Xanthomonas citri subsp. citri (X. citri). Thus, sanitization of fresh fruit is a necessary measure before any commercial activity. Therefore, we evaluated the clove essential ... -
A Novel Ruthenium(II) Complex With Lapachol Induces G2/M Phase Arrest Through Aurora-B Kinase Down-Regulation and ROS-Mediated Apoptosis in Human Prostate Adenocarcinoma Cells
De Grandis, Rone A.; ; ; ; ; ; Pavan, Fernando R. (Frontiers in Oncology, 2021) [Artigo]
Lapachol is a well-studied natural product that has been receiving great interest due to its anticancer properties that target oxidative stress. In the present work, two novel lapachol-containing ruthenium(II) complexes ... -
Evaluation of calcium hydroxide, calcium hypochlorite, peracetic acid, and potassium bicarbonate as citrus fruit sanitizers
Dilarri, Guilherme; Zamuner, Caio Felipe Cavicchia ; Bacci, Mauricio ; Ferreira, Henrique (Journal of Food Science and Technology, 2021) [Artigo]
Xanthomonas citri (X. citri) is a quarentenary plant pathogen and the causal agent of the citrus canker. X. citri forms biofilms and remains fixed on the surface of plant tissues, especially on leaves and fruits. Considering ... -
Formal assignation of the kissing bug triatoma lecticularia (Hemiptera: Reduviidae: Triatominae) to the genus paratriatoma
; ; ; ; ; Rosa, João Aristeu da (Insects, 2021) [Artigo]
The subfamily Triatominae (Hemiptera: Reduviidae) comprises hematophagous insects that are vectors of Chagas disease; including species assigned to the genera Triatoma and Paratriatoma. Initial examination of Triatoma ... -
Chemical, spectroscopic characterization, molecular modeling and antibacterial activity assays of a silver (I) complex with succinic acid
; ; ; Cavicchioli, Maurício; Amaral Machado, Rachel Temperani ; Pavan, Fernando Rogério ; ; ; ; Massabni, Antonio Carlos (Ecletica Quimica, 2021) [Artigo]
A silver(I) complex with succinic acid in the form of succinate is presented. Chemical characterization confirms the molecular composition Ag2C4H4O4 for the complex. Infrared spectra suggest a bidentate coordination of ... -
Planejamento, síntese e atividade anti-Mycobacterium tuberculosis de derivados N-óxidos
dos Santos Fernandes, Guilherme Felipe; de Souza, Paula Carolina ; ; Solcia, Mariana Cristina ; ; Chin, Chung Man ; ; ; Pavan, Fernando Rogério ; dos Santos, Jean Leandro (Revista de Ciencias Farmaceuticas Basica e Aplicada, 2017) [Nota]
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Avaliação da atividade anti-mycobacterium tuberculosis e citotoxicidade dos ligantes hinokitiol e tropolona e seus complexos com paládio e platina
Silva, Ana Paula Souza; Ribeiro, Camila Maríngolo ; Solcia, Mariana Cristina ; ; ; Pavan, Fernando Rogério (Revista de Ciencias Farmaceuticas Basica e Aplicada, 2017) [Nota]