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dc.contributor.authorde Castro, Karina Ferreira [UNESP]
dc.contributor.authorArtoni, Silvana Martinez Baraldi [UNESP]
dc.contributor.authorPacheco, Maria Rita [UNESP]
dc.date.accessioned2014-05-27T11:27:24Z
dc.date.available2014-05-27T11:27:24Z
dc.date.issued2012-12-01
dc.identifierhttp://www.revistas.usp.br/bjvras/article/view/42093
dc.identifier.citationBrazilian Journal of Veterinary Research and Animal Science, v. 49, n. 3, p. 193-201, 2012.
dc.identifier.issn1413-9596
dc.identifier.issn1678-4456
dc.identifier.urihttp://hdl.handle.net/11449/74017
dc.description.abstractAtherosclerosis is a multifactorial, progressive and slow disease, and hyperlipidaemia is one of the potential factors in the development of atherosclerotic cardiac diseases. The experimental dyslipidaemia carrying out advantages are the production of atheromatous lesions in a short period of time, an adequate dietetic control and environmental factors, the possibility of studies concerning reversibility of atherosclerotic lesions, and pre-clinic experiments with hypolipidaemic substances. This study aims at evaluating tyloxapol analyzing serum lipid levels. Twenty-eight healthy Wistar adults' albino male rats, weighing an average of 200 g were utilized. They were distributed into four experimental groups with seven animals each, as follows: Group I - (control); Group II - treated with tyloxapol at a dose of 500mg/kg of body weight, through intraperitoneal via each 48 hours, for two weeks; Group III - treated with tyloxapol at a dose of 500mg/ kg of body weight, through intraperitoneal via each 48 hours, for three weeks; Group IV - treated with tyloxapol at a dose of 500mg/kg of body weight, through intraperitoneal via each 48 hours, for four weeks. As lipid profile evaluation is concerned, the values of triacylglycerols and HDL have indicated that group III has significantly differed from group I and the values of total cholesterol and LDL have indicated that group I has significantly differed from group II, III and IV. It was concluded that for the studied period the surfactant tyloxapol was effective to inducing hyperlipidaemia.en
dc.format.extent193-201
dc.language.isoeng
dc.language.isopor
dc.relation.ispartofBrazilian Journal of Veterinary Research and Animal Science
dc.sourceScopus
dc.subjectCholesterol
dc.subjectLipid profile
dc.subjectRat
dc.subjectSurfactant
dc.subjectTriacylglycerol
dc.subjectAnimalia
dc.subjectRattus
dc.titlePerfil lipídico sérico de ratos tratados com surfactantept
dc.title.alternativeSerum lipid levels of rats treated with surfactanten
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/bjvras/paboutj.htm
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationPós Graduanda em Clínica Médica Veterinária Universidade Estadual Paulista Júlio de Mesquita Filho, Jaboticabal-SP
dc.description.affiliationDepartamento de Morfologia e Fisiologia Animal Universidade Estadual Paulista Júlio de Mesquita Filho, Jaboticabal-SP
dc.description.affiliationUnespPós Graduanda em Clínica Médica Veterinária Universidade Estadual Paulista Júlio de Mesquita Filho, Jaboticabal-SP
dc.description.affiliationUnespDepartamento de Morfologia e Fisiologia Animal Universidade Estadual Paulista Júlio de Mesquita Filho, Jaboticabal-SP
dc.rights.accessRightsAcesso aberto
dc.identifier.scopus2-s2.0-84872578621
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt
dc.identifier.file2-s2.0-84872578621.pdf
dc.identifier.lattes4808768181688517
unesp.author.lattes4808768181688517
dc.relation.ispartofsjr0,225
dc.relation.ispartofsjr0,225
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