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dc.contributor.authorSilva, Danilo A. [UNESP]
dc.contributor.authorBasso, Glaucia G. [UNESP]
dc.contributor.authorSemenzim, Vinícius L. [UNESP]
dc.contributor.authorGodoy, Moacir F.
dc.contributor.authorTaboga, Sebastião R. [UNESP]
dc.contributor.authorAndrade, Alexandre L. [UNESP]
dc.contributor.authorLuvizotto, Maria Cecília Rui [UNESP]
dc.contributor.authorBraile, Domingo M.
dc.contributor.authorNery, Jose G. [UNESP]
dc.date.accessioned2014-05-27T11:28:17Z
dc.date.available2014-05-27T11:28:17Z
dc.date.issued2013-02-01
dc.identifierhttp://dx.doi.org/10.1002/jbm.a.34334
dc.identifier.citationJournal of Biomedical Materials Research - Part A, v. 101 A, n. 2, p. 326-339, 2013.
dc.identifier.issn1549-3296
dc.identifier.issn1552-4965
dc.identifier.urihttp://hdl.handle.net/11449/74442
dc.description.abstractThe results of the histopathological analyses after the implantation of highly crystalline PVA microspheres in subcutaneous tissues of Wistar rats are here in reported. Three different groups of PVA microparticles were systematically studied: highly crystalline, amorphous, and commercial ones. In addition to these experiments, complementary analyses of architectural complexity were performed using fractal dimension (FD), and Shannon's entropy (SE) concepts. The highly crystalline microspheres induced inflammatory reactions similar to the ones observed for the commercial ones, while the inflammatory reactions caused by the amorphous ones were less intense. Statistical analyses of the subcutaneous tissues of Wistar rats implanted with the highly crystalline microspheres resulted in FD and SE values significantly higher than the statistical parameters observed for the amorphous ones. The FD and SE parameters obtained for the subcutaneous tissues of Wistar rats implanted with crystalline and commercial microparticles were statistically similar. Briefly, the results indicated that the new highly crystalline microspheres had biocompatible behavior comparable to the commercial ones. In addition, statistical tools such as FD and SE analyses when combined with histopathological analyses can be useful tools to investigate the architectural complexity tissues caused by complex inflammatory reactions. © 2012 WILEY PERIODICALS, INC.en
dc.format.extent326-339
dc.language.isoeng
dc.relation.ispartofJournal of Biomedical Materials Research - Part A
dc.sourceScopus
dc.subjectEmbolization
dc.subjectFractal dimension
dc.subjectInflammatory reaction
dc.subjectPoly(vinyl alcohol)
dc.subjectShannon's entropy
dc.subjectComplementary analysis
dc.subjectHistopathological analysis
dc.subjectMicro-particles
dc.subjectStatistical parameters
dc.subjectStatistical tools
dc.subjectSubcutaneous tissues
dc.subjectWistar rat
dc.subjectArchitecture
dc.subjectFinite difference method
dc.subjectHistology
dc.subjectInformation theory
dc.subjectMicrospheres
dc.subjectPolyvinyl alcohols
dc.subjectStatistical mechanics
dc.subjectTissue
dc.subjectCrystalline materials
dc.subjectmicrosphere
dc.subjectpolyvinyl alcohol
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectbiocompatibility
dc.subjectchemical structure
dc.subjectcontrolled study
dc.subjectcrystal structure
dc.subjectentropy
dc.subjectfractal analysis
dc.subjecthistopathology
dc.subjectinflammation
dc.subjectnonhuman
dc.subjectrat
dc.subjectscanning electron microscopy
dc.subjectsubcutaneous tissue
dc.subjectsynthesis
dc.subjectX ray diffraction
dc.subjectAnimals
dc.subjectCrystallization
dc.subjectEntropy
dc.subjectFractals
dc.subjectImplants, Experimental
dc.subjectInflammation
dc.subjectMicroscopy, Electron, Scanning
dc.subjectPolyvinyl Alcohol
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectSubcutaneous Tissue
dc.subjectX-Ray Diffraction
dc.titleFractal dimension and Shannon's entropy analyses of the architectural complexity caused by the inflammatory reactions induced by highly crystalline polyvinyl alcohol) microspheres implanted in subcutaneous tissues of the Wistar ratsen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionBraile Biomedica Ltda.
dc.contributor.institutionFaculdade de Medicina de São José do Rio Preto (FAMERP)
dc.description.affiliationDepartamento de Física Instituto de Biociências, Letras e Ciências Exatas Universidade Estadual Paulista (UNESP), São Jose do Rio Preto - São Paulo 15054-000
dc.description.affiliationBraile Biomedica Industria Comercio e Representações Limitada, São Jose do Rio Preto - São Paulo 15091-450
dc.description.affiliationDepartamento de Cardiologia e Cirurgia Cardiovascular Nucleo Transdisciplinar para Estudo do Caos e da Complexidade (NUTECC) Faculdade de Medicina de São Jose do Rio Preto (FAMERP), São Jose do Rio Preto - São Paulo 15090-000
dc.description.affiliationDepartamento de Biologia Instituto de Biociências, Letras e Ciências Exatas Universidade Estadual Paulista (UNESP), São Jose do Rio Preto - São Paulo 15054-000
dc.description.affiliationDepartamento de Clínica, Cirurgia e Reprodução Animal Faculdade de Medicina Veterinaria Universidade Estadual Paulista (UNESP), Araçatuba - São Paulo 16050-680
dc.description.affiliationUnespDepartamento de Física Instituto de Biociências, Letras e Ciências Exatas Universidade Estadual Paulista (UNESP), São Jose do Rio Preto - São Paulo 15054-000
dc.description.affiliationUnespDepartamento de Biologia Instituto de Biociências, Letras e Ciências Exatas Universidade Estadual Paulista (UNESP), São Jose do Rio Preto - São Paulo 15054-000
dc.description.affiliationUnespDepartamento de Clínica, Cirurgia e Reprodução Animal Faculdade de Medicina Veterinaria Universidade Estadual Paulista (UNESP), Araçatuba - São Paulo 16050-680
dc.identifier.doi10.1002/jbm.a.34334
dc.identifier.wosWOS:000312728000003
dc.rights.accessRightsAcesso restrito
dc.identifier.scopus2-s2.0-84872685424
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina Veterinária, Araçatubapt
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt
dc.identifier.lattes6404176495306171
dc.identifier.lattes4584674909952477
dc.identifier.orcid0000-0002-0970-4288
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