Doxorubicin induced dilated cardiomyopathy in a rabbit model: An update
Data de publicação2013-02-01
Direito de acesso
MetadadosExibir registro completo
Dilated cardiomyopathy (DCM) is characterized by chamber dilation and cardiac dysfunction. Because of the poor prognosis, models are needed for the investigation of and development of new therapeutic approaches, as well as stem cell therapy. Doxorubicin (DOX), used as chemotherapeutic agent, is reported to be cumulative cardiotoxic causing DCM. The aim of the study was to investigate the onset of systolic dysfunction using echocardiography in rabbits receiving two different doses of DOX (1. mg/kg twice a week and 2. mg/kg once a week). Twenty rabbits were treated with doxorubicin in two different doses for 6. weeks and compared with a control group treated with NaCl 0.9%. The effect of doxorubicin on the myocardium was investigated with histological analysis and scanning electron microscopy of left ventricle (LV), as well as in the interventricular septum (IVS) and right ventricle (RV). The results showed a high mortality rate for rabbits receiving 2. mg/kg once a week. A significant reduction in systolic function was present in animals treated with DOX after 6. weeks, with decreased ejection fraction and shortening fraction. Histology and electron microscopy revealed vacuolization, intracytoplasmic granulation, necrosis and interstitial fibrosis in LV, as well as in the IVS and RV. Doxorubicin induced changes are present in the LV, RV and IVS, and the administration at the dose of 1. mg/kg twice a week for only 6. weeks is safe and sufficient to induce DCM in rabbits. © 2012 Elsevier Ltd.
Como citar este documento
Exibindo os itens relacionados pelo título, autor e palavra-chave.
Soriano, Eline A. ; Gaiolla, Paula Schmidt Azevedo ; Miot, Hélio Amante ; Minicucci, Marcos Ferreira ; Pansani, Mariele C. ; Matsubara, Luiz Shiguero ; Okoshi, Katashi ; Zornoff, Leonardo Antonio Mamede ; Matsubara, Beatriz Bojikian ; Paiva, Sergio A.R. (International Journal of Cardiology, 2013) [Artigo]Background: Currently, 13-cis-retinoic acid (13-cis-RA) is the most effective therapy for acne. Isotretinoin, a first-generation synthetic 13-cis-RA compound, is associated with numerous adverse effects. To investigate the ...
Damatto, R. L. ; Martinez, P. F. ; Lima, A. R R ; Cezar, M. D M ; Campos, D. H S ; Oliveira Junior, S. A. ; Guizoni, D. M. ; Bonomo, C. ; Nakatani, B. T. ; Dal Pai Silva, M. et al. (International Journal of Cardiology, 2013) [Artigo]Background: Although skeletal muscle atrophy and changes in myosin heavy chain (MyHC) isoforms have often been observed during heart failure, their pathophysiological mechanisms are not completely defined. In this study ...
Waist circumference, but not body mass index, is a predictor of ventricular remodeling after anterior myocardial infarction Cogni, Ana Lucia ; Farah, Elaine ; Minicucci, Marcos Ferreira ; Gaiolla, Paula Schmidt Azevedo ; Okoshi, Katashi ; Matsubara, Beatriz Bojikian ; Zanati, Silméia G. ; Paiva, Sergio A.R. ; Zornoff, Leonardo Antonio Mamede (Nutrition, 2013) [Artigo]Objective: The impact of obesity on ventricular remodeling after myocardial infarction (MI) is still poorly understood. Therefore, the aim of this study was to evaluate the role of waist circumference (WC) and body mass ...