Evaluation of the bone healing process utilizing platelet-rich plasma activated by thrombin and calcium chloride: A histologic study in rabbit calvaria
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Data
2013-02-01
Autores
Betoni Junior, Walter
Dechichi, Paula
Esteves, Jônatas Caldeira
Zanetta-Barbosa, Darceny
Magalhães, Aparecido Eurípedes Onório
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Resumo
To evaluate the bone healing of defects filled with particulate bone graft in combination with platelet-rich plasma (PRP), added with a mixture of calcium chloride and thrombin or just calcium chloride. Two 5-mm bone defects were created in the calvaria of 24 rabbits. Each defect was filled with particulate bone graft and PRP. In one defect the PRP was activated by a mixture of calcium chloride and thrombin; in the other, PRP was activated by calcium chloride only. The animals were euthanized 1, 2, 4, and 8 weeks after the surgeries, and the calvaria was submitted to histologic processing for histomorphometric analysis. The qualitative analysis has shown that both defects presented the same histologic characteristics so that a better organized, more mature, and well-vascularized bone tissue was noticed in the eighth week. A good bone repair was achieved using either the mixture of calcium chloride and thrombin or the calcium chloride alone as a restarting agent of the coagulation process.
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Bone graft, Dental implants, Growth factors, Platelet-rich plasma, calcium chloride, thrombin, animal, blood clotting, bone regeneration, drug effect, evaluation, rabbit, skull, thrombocyte rich plasma, Animals, Blood Coagulation, Bone Regeneration, Calcium Chloride, Platelet-Rich Plasma, Rabbits, Skull, Thrombin
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Journal of Oral Implantology, v. 39, n. 1, p. 14-21, 2013.