Adjunctive antimicrobial photodynamic treatment of experimentally induced periodontitis in rats with ovariectomy
Data de publicação2013-04-01
Direito de acesso
MetadadosExibir registro completo
Background: The aim of this study is to compare antimicrobial photodynamic therapy (aPDT) as an adjunctive therapy to scaling and root planing (SRP) for the treatment of experimentally induced periodontitis in rats with ovariectomy (OVX) that are or are not treated with estrogen replacement. Methods: A total of 270 female rats were divided into three groups: 1) normal rats; 2) rats with OVX; and 3) rats with OVX with estrogen replacement. Periodontal disease was induced through the introduction of a cotton thread around the mandibular left first molar. After 7 days, the ligature was removed, and the rats were randomly divided into the following treatment groups: 1) SRP plus saline solution; 2) SRP plus low-level laser therapy (LLLT); and 3) SRP plus toluidine blue O irrigation followed by LLLT. Ten rats from each group were euthanized at days 7, 15, and 30 after dental treatment. Bone loss (BL) in the furcation region was evaluated using histometric and immunohistochemical analyses. Results: aPDT treatment resulted in reduced BL compared with SRP treatment at all time points. Additionally, rats treated with aPDT exhibited reduced numbers of tartrate-resistant acid-phosphatase-positive cells and more proliferating cell nuclear antigen-positive cells in all treatment groups regardless of estrogen status. Whereas rats treated with aPDT showed weak immunoreactivity to the receptor activator of nuclear factor-k B ligand at day 7 post-treatment, strong osteoprotegerin immunoreactivity was observed at day 15 post-treatment. Conclusion: aPDT is an effective adjunctive therapy for the treatment of periodontitis in rats with OVX that are or are not given estrogen replacement therapy.
Como citar este documento
Exibindo os itens relacionados pelo título, autor e palavra-chave.
Dental students' familiarity with the medical management of dental patients at Brazilian dental schools Araújo, Paula Caetano; Garbin, Clea Adas Saliba ; Moimaz, Suzely Adas Saliba ; Saliba, Nemre Adas ; Arcieri, Renato Moreira (Journal of Dental Education, 2013) [Artigo]Drug therapy in dentistry is essential for patients' treatment and requires special care by dentists, so it must be part of a well-grounded education for predoctoral dental students. The aim of this study was to evaluate ...
Efficacy of hormone therapy with and without methyltestosterone augmentation of venlafaxine in the treatment of postmenopausal depression: A double-blind controlled pilot study Dias, Rogerio ; Kerr-Corrêa, Florence ; Moreno, Ricardo A.; Trinca, Luzia A.; Pontes, Anaglória ; Halbe, Hans W.; Gianfaldoni, Arlete; Dalben, Ivete (Menopause, 2006) [Artigo]Objective: This study evaluated the augmentation of venlafaxine with hormone therapy in the treatment of postmenopausal depression. The hormones evaluated were estrogen (0.625 mg) in combination with medroxyprogesterone ...
Effect of ultrasonic instrumentation on the bond strength of crowns cemented with zinc phosphate cement to natural teeth. An in vitro study de Melo Filho, Antonio Braulino ; Mori, Matsuyoshi; Jardini, Maria Aparecida Neves ; Landim, Karine Tenório ; Solis, Ana Cristina de Oliveira (Brazilian Oral Research, 2008) [Artigo]Several studies have reported the benefits of sonic and/or ultrasonic instrumentation for root debridement, with most of them focusing on changes in periodontal clinical parameters. The present study investigated possible ...