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dc.contributor.authorTaxini, C. L. [UNESP]
dc.contributor.authorPuga, C. C I [UNESP]
dc.contributor.authorDias, M. B. [UNESP]
dc.contributor.authorBícego, K. C. [UNESP]
dc.contributor.authorGargaglioni, L. H. [UNESP]
dc.date.accessioned2014-05-27T11:29:02Z
dc.date.available2014-05-27T11:29:02Z
dc.date.issued2013-05-01
dc.identifierhttp://dx.doi.org/10.1111/apha.12082
dc.identifier.citationActa Physiologica, v. 208, n. 1, p. 125-135, 2013.
dc.identifier.issn1748-1708
dc.identifier.issn1748-1716
dc.identifier.urihttp://hdl.handle.net/11449/75256
dc.description.abstractAim: Central chemoreceptors are important to detect changes of CO2/H+, and the Locus coeruleus (LC) is one of the many putative central chemoreceptor sites. Here, we studied the contribution of LC glutamatergic receptors on ventilatory, cardiovascular and thermal responses to hypercapnia. Methods: To this end, we determined pulmonary ventilation (VE), body temperatures (Tb), mean arterial pressure (MAP) and heart rate (HR) of male Wistar rats before and after unilateral microinjection of kynurenic acid (KY, an ionotropic glutamate receptor antagonist, 10 nmol/0.1 μL) or α-methyl-4-carboxyphenylglycine (MCPG, a metabotropic glutamate receptor antagonist, 10 nmol/0.1 μL) into the LC, followed by 60 min of air breathing or hypercapnia exposure (7% CO2). Results: Ventilatory response to hypercapnia was higher in animals treated with KY intra-LC (1918.7 ± 275.4) compared with the control group (1057.8 ± 213.9, P < 0.01). However, the MCPG treatment within the LC had no effect on the hypercapnia-induced hyperpnea. The cardiovascular and thermal controls were not affected by hypercapnia or by the injection of KY and MCPG in the LC. Conclusion: These data suggest that glutamate acting on ionotropic, but not metabotropic, receptors in the LC exerts an inhibitory modulation of hypercapnia-induced hyperpnea. © 2013 Scandinavian Physiological Society.en
dc.format.extent125-135
dc.language.isoeng
dc.relation.ispartofActa Physiologica
dc.sourceScopus
dc.subjectChemosensitivity
dc.subjectGlutamate
dc.subjectHypercapnia
dc.subjectPulmonary ventilation
dc.subjectalpha methyl 4 carboxyphenylglycine
dc.subjectglutamic acid
dc.subjectkynurenic acid
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectbody temperature
dc.subjectbreathing
dc.subjectchemoreceptor
dc.subjectcontrol group
dc.subjectcontrolled study
dc.subjectheart rate
dc.subjecthypercapnia
dc.subjectlocus ceruleus
dc.subjectlung ventilation
dc.subjectmale
dc.subjectmean arterial pressure
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectrat
dc.titleIonotropic but not metabotropic glutamatergic receptors in the locus coeruleus modulate the hypercapnic ventilatory response in unanaesthetized ratsen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationDepartment of Animal Morphology and Physiology Sao Paulo State University-FCAV, Jaboticabal, SP
dc.description.affiliationDepartment of Biology Sao Paulo State University-IBILCE, São José do Rio Pretol, SP
dc.description.affiliationDepartment of Physiology Institute of Bioscience Sao Paulo State University-UNESP, Botucatu, SP
dc.description.affiliationUnespDepartment of Animal Morphology and Physiology Sao Paulo State University-FCAV, Jaboticabal, SP
dc.description.affiliationUnespDepartment of Biology Sao Paulo State University-IBILCE, São José do Rio Pretol, SP
dc.description.affiliationUnespDepartment of Physiology Institute of Bioscience Sao Paulo State University-UNESP, Botucatu, SP
dc.identifier.doi10.1111/apha.12082
dc.identifier.wosWOS:000317678000014
dc.rights.accessRightsAcesso restrito
dc.identifier.scopus2-s2.0-84876324740
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt
dc.relation.ispartofjcr5.930
dc.relation.ispartofsjr1,542
dc.relation.ispartofsjr1,542
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