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dc.contributor.authorNars, Mariana S. [UNESP]
dc.contributor.authorKaneno, Ramon [UNESP]
dc.date.accessioned2014-05-27T11:29:33Z
dc.date.available2014-05-27T11:29:33Z
dc.date.issued2013-06-01
dc.identifierhttp://dx.doi.org/10.1002/ijc.27801
dc.identifier.citationInternational Journal of Cancer, v. 132, n. 11, p. 2471-2478, 2013.
dc.identifier.issn0020-7136
dc.identifier.issn1097-0215
dc.identifier.urihttp://hdl.handle.net/11449/75470
dc.description.abstractGiven that cancer is one of the main causes of death worldwide, many efforts have been directed toward discovering new treatments and approaches to cure or control this group of diseases. Chemotherapy is the main treatment for cancer; however, a conventional schedule based on maximum tolerated dose (MTD) shows several side effects and frequently allows the development of drug resistance. On the other side, low dose chemotherapy involves antiangiogenic and immunomodulatory processes that help host to fight against tumor cells, with lower grade of side effects. In this review, we present evidence that metronomic chemotherapy, based on the frequent administration of low or intermediate doses of chemotherapeutics, can be better than or as efficient as MTD. Finally, we present some data indicating that noncytotoxic concentrations of antineoplastic agents are able to both up-regulate the immune system and increase the susceptibility of tumor cells to cytotoxic T lymphocytes. Taken together, data from the literature provides us with sufficient evidence that low concentrations of selected chemotherapeutic agents, rather than conventional high doses, should be evaluated in combination with immunotherapy. Copyright © 2012 UICC.en
dc.format.extent2471-2478
dc.language.isoeng
dc.relation.ispartofInternational Journal of Cancer
dc.sourceScopus
dc.subjectchemotherapy
dc.subjectdendritic cells
dc.subjectimmunotherapy
dc.subjectmetronomic
dc.subjectTreg
dc.subjectvaccine
dc.subject5 aza 2' deoxycytidine
dc.subjectadenovirus vector
dc.subjectantineoplastic agent
dc.subjectbevacizumab
dc.subjectcelecoxib
dc.subjectcetuximab
dc.subjectcisplatin
dc.subjectcyclophosphamide
dc.subjectdendritic cell vaccine
dc.subjectdocetaxel
dc.subjectdoxorubicin
dc.subjectetoposide
dc.subjectfluorouracil
dc.subjectfolinic acid
dc.subjectgemcitabine
dc.subjectgranulocyte colony stimulating factor
dc.subjectidarubicin
dc.subjectinterleukin 12
dc.subjectirinotecan
dc.subjectmercaptopurine
dc.subjectmethotrexate
dc.subjectmitomycin
dc.subjectmitoxantrone
dc.subjectoxaliplatin
dc.subjectpaclitaxel
dc.subjectrofecoxib
dc.subjecttumor cell vaccine
dc.subjectunindexed drug
dc.subjectvinblastine
dc.subjectvincristine
dc.subjectadvanced cancer
dc.subjectalopecia
dc.subjectantiangiogenic activity
dc.subjectantineoplastic activity
dc.subjectarthralgia
dc.subjectbleeding
dc.subjectblood toxicity
dc.subjectbone marrow suppression
dc.subjectbrain damage
dc.subjectbreast cancer
dc.subjectbreast metastasis
dc.subjectcancer chemotherapy
dc.subjectcancer combination chemotherapy
dc.subjectcancer immunotherapy
dc.subjectcancer resistance
dc.subjectcolon cancer
dc.subjectcolon carcinoma
dc.subjectcolorectal cancer
dc.subjectcytokine response
dc.subjectcytotoxic T lymphocyte
dc.subjectdepression
dc.subjectdigestive system function disorder
dc.subjectDNA methylation
dc.subjectdose calculation
dc.subjectdose response
dc.subjectdrug cytotoxicity
dc.subjectdrug megadose
dc.subjectdrug potentiation
dc.subjectdrug safety
dc.subjectdrug sensitivity
dc.subjectheat injury
dc.subjectHodgkin disease
dc.subjecthuman
dc.subjectimmunological tolerance
dc.subjectimmunomodulation
dc.subjectimmunostimulation
dc.subjectinfection
dc.subjectleukemia
dc.subjectleukopenia
dc.subjectliver toxicity
dc.subjectlow dose metronomic chemotherapy
dc.subjectlow drug dose
dc.subjectlung carcinoma
dc.subjectlung non small cell cancer
dc.subjectlymphocytopenia
dc.subjectlymphoma
dc.subjectmaintenance therapy
dc.subjectmalignant neoplastic disease
dc.subjectmaximum tolerated dose
dc.subjectmelanoma
dc.subjectmucosal disease
dc.subjectmultiple myeloma
dc.subjectneoplasm
dc.subjectneuroblastoma
dc.subjectneutropenia
dc.subjectnonhuman
dc.subjectovary cancer
dc.subjectpriority journal
dc.subjectreview
dc.subjectside effect
dc.subjectsingle drug dose
dc.subjectstomach tumor
dc.subjectT cell depletion
dc.subjectthrombocytopenia
dc.subjectthromboembolism
dc.subjectviral gene delivery system
dc.subjectweight reduction
dc.subjectAnimals
dc.subjectAntineoplastic Agents
dc.subjectCombined Modality Therapy
dc.subjectHumans
dc.subjectImmunologic Factors
dc.subjectImmunotherapy
dc.subjectNeoplasms
dc.titleImmunomodulatory effects of low dose chemotherapy and perspectives of its combination with immunotherapyen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.description.affiliationDepartamento de Microbiologia e Imunologia Instituto de Biociências de Botucatu UNESP-Univ Estadual Paulista, Cx Postal 510, Distrito de Rubião Jr. s/n, 18618-970, Botucatu, São Paulo
dc.description.affiliationDepartment of Pathology School of Medicine UNESP-Univ Estadual Paulista, Botucatu, São Paulo
dc.description.affiliationUnespDepartamento de Microbiologia e Imunologia Instituto de Biociências de Botucatu UNESP-Univ Estadual Paulista, Cx Postal 510, Distrito de Rubião Jr. s/n, 18618-970, Botucatu, São Paulo
dc.description.affiliationUnespDepartment of Pathology School of Medicine UNESP-Univ Estadual Paulista, Botucatu, São Paulo
dc.identifier.doi10.1002/ijc.27801
dc.identifier.wosWOS:000316824000002
dc.rights.accessRightsAcesso restrito
dc.identifier.scopus2-s2.0-84875600868
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
dc.identifier.lattes8845835550637809
dc.identifier.orcid0000-0002-4292-3298
unesp.author.lattes8845835550637809[2]
unesp.author.orcid0000-0002-4292-3298[2]
dc.relation.ispartofjcr7.360
dc.relation.ispartofsjr3,152
dc.relation.ispartofsjr3,152
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