Previous contact with Strongyloides venezuelensis contributed to prevent insulitis in MLD-STZ diabetes
MetadataShow full item record
Epidemiological and experimental studies support the idea that helminth infections can induce a protective effect against the development of autoimmune and allergic diseases. In this study we characterized the immune response induced by Strongyloides venezuelensis infection in C57BL/6 mice and then evaluated the effect of a previous contact with this helminth in the outcome of type 1 diabetes. Animals were initially infected with 2000 L3 larvae from S. venezuelensis and euthanized 22. days later. An acute phase, identified by a high amount of eggs per gram of feces, was established between days 7 and 9 post-infection. Recovery from infection was associated with a Th2 polarized response characterized by a significant level of serum IgG1 specific antibodies and also a significant production of IL-5 and IL-10 by spleen cells stimulated with S. venezuelensis soluble antigen. Immunization with soluble S. venezuelensis antigen associated with complete Freund's adjuvant followed by infection with S. venezuelensis protected mice from diabetes development induced by streptozotocin. Protection was characterized by a higher body weight gain, lower glycemic levels, much less severe insulitis and preserved insulin production. Together, these results indicate that S. venezuelensis contributed to protect C57BL/6 mice against experimental diabetes induced by streptozotocin. © 2013 Elsevier Inc.
How to cite this document
Showing items related by title, author, creator and subject.
De Freitas Alvarenga, Kátia; Duarte, Josilene Luciene; Camargo Da Silva, Daniela Polo ; Agostinho-Pesse, Raquel Sampaio ; Negrato, Carlos Antonio ; Alves Costa, Orozimbo (Revista Brasileira de Otorrinolaringologia, 2005) [Artigo]Diabetes Mellitus may lead to alterations in the eyes, kidneys, cranial nerves, peripheral nerves, ears etc. The cognitive function, also, seems to be compromised in subjects presented with Diabetes Mellitus, since the ...
Influence of treatment with quercetin on lipid parameters and oxidative stress of pregnant diabetic rats Pereira Braga, Camila ; Momentti, Ana Carolina ; Barbosa Peixoto, Fernando ; de Fátima Ferreira Baptista, Rafaela ; dos Santos, Felipe André ; Fava, Fábio Henrique ; Fernandes, Ana Angélica Henrique (Canadian Journal of Physiology and Pharmacology, 2013) [Artigo]Among the numerous coadjuvant therapies that could influence the incidence and progression of diabetic complications, antioxidants and flavonoids are currently being tested in clinical trials. We investigated the effect ...
Evaluation of toxicity after one-months treatment with Bauhinia forficata decoction in streptozotocin-induced diabetic rats Pepato, Maria Teresa ; Baviera, Amanda Martins ; Vendramini, Regina Célia ; Brunetti, Iguatemy Lourenço (BMC Complementary and Alternative Medicine, 2004) [Artigo]Background: Previous experiments have shown that a decoction of Bauhinia forficata leaves reduces the changes in carbohydrate and protein metabolism that occur in rats with streptozotocin-induced diabetes. In the present ...