Presence of autoantibodies against small nuclear ribonucleoprotein epitopes in Chagas' patients' sera

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Data

1998-10-01

Autores

Bach-Elias, M.
Bahia, D.
Teixeira, D. C.
Cicarelli, RMB

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Springer

Resumo

We investigated the possibility that Chagas' patients develop an autoimmune response to human UsnRNPs (small nuclear ribonucleoprotein) or Sm epitopes. Using purified human UsnRNPs, we detected anti-human UsnRNPs antibodies in sera from patients suffering from Chagas' disease. The antibodies it-ere also detected using peptide enzyme-linked immunosorbent assays containing the Sm-motif 1 domain. The latter technique showed that 61% (31/51) of the Chagas' patients' sera contained antibodies against Sm-motif I. The detection of anti-UsnRNPs autoantibodies in Chagas patients' sera strongly encourages further studies using animal models to determine how these autoantibodies appear.

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Parasitology Research. New York: Springer Verlag, v. 84, n. 10, p. 796-799, 1998.