Presence of autoantibodies against small nuclear ribonucleoprotein epitopes in Chagas' patients' sera
Nenhuma Miniatura disponível
Data
1998-10-01
Autores
Bach-Elias, M.
Bahia, D.
Teixeira, D. C.
Cicarelli, RMB
Título da Revista
ISSN da Revista
Título de Volume
Editor
Springer
Resumo
We investigated the possibility that Chagas' patients develop an autoimmune response to human UsnRNPs (small nuclear ribonucleoprotein) or Sm epitopes. Using purified human UsnRNPs, we detected anti-human UsnRNPs antibodies in sera from patients suffering from Chagas' disease. The antibodies it-ere also detected using peptide enzyme-linked immunosorbent assays containing the Sm-motif 1 domain. The latter technique showed that 61% (31/51) of the Chagas' patients' sera contained antibodies against Sm-motif I. The detection of anti-UsnRNPs autoantibodies in Chagas patients' sera strongly encourages further studies using animal models to determine how these autoantibodies appear.
Descrição
Palavras-chave
Como citar
Parasitology Research. New York: Springer Verlag, v. 84, n. 10, p. 796-799, 1998.