Diabetic rats exercised prior to and during pregnancy: Maternal reproductive outcome, biochemical profile, and frequency of fetal anomalies
Nenhuma Miniatura disponível
Data
2013-07-01
Autores
Damasceno, Débora Cristina [UNESP]
Silva, Hellen Pontes [UNESP]
Vaz, Geizi Fátima [UNESP]
Vasques-Silva, Francine Aparecida [UNESP]
Calderon, Iracema de Mattos Paranhos [UNESP]
Rudge, Marilza Vieira Cunha [UNESP]
Campos, Kleber Eduardo de [UNESP]
Volpato, Gustavo Tadeu [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
The aim of this study was to evaluate the effects of exercise prior to or during pregnancy on maternal reproductive outcome, biochemical profile, and on fetal anomaly frequency in a rat pregnancy model utilizing chemically induced diabetes. Wistar rats (minimum n = 11 animals/group) were randomly assigned the following groups: group 1 (G1), sedentary, nondiabetic; G2, nondiabetic, exercised during pregnancy; G3, nondiabetic, exercised prior to and during pregnancy; G4, sedentary, diabetic; G5, diabetic, exercised during pregnancy; and G6, diabetic, exercised prior to and during pregnancy. A swimming program was utilized for moderate exercise. On day 21 of pregnancy, all rats were anesthetized to obtain blood for biochemical measurements. The gravid uterus was weighed with its contents, and the fetuses were analyzed. The nondiabetic rats exercised prior to pregnancy presented a reduced maternal weight gain. Besides, G2 and G3 groups showed decreased fetal weights at term pregnancy, indicating slight intrauterine growth restriction (IUGR). In the diabetic dams, the swimming program did not have antihyperglycemic effects. The exercise applied only during pregnancy caused severe IUGR, as confirmed by reduced fetal weight mean, fetal weight classification, and ossification sites. Nevertheless, exercise was not a teratogenic factor and improved the rats' lipid profiles, demonstrating that the exercise presented possible benefits, but there are also risks prior and during pregnancy, especially in diabetic pregnant women. © The Author(s) 2012.
Descrição
Palavras-chave
anomaly, diabetes mellitus, exercise, pregnancy, reproductive outcome, glucose, animal experiment, animal model, biochemistry, blood sampling, controlled study, female, fetus, fetus malformation, fetus weight, intrauterine growth retardation, morbidity, nonhuman, ossification, pregnancy diabetes mellitus, pregnancy outcome, priority journal, rat, review, sedentary lifestyle, streptozocin diabetes, swimming, weight gain
Como citar
Reproductive Sciences, v. 20, n. 7, p. 730-738, 2013.