Praziquantel-loaded PLGA nanoparticles: preparation and characterization
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Data
2005-02-01
Autores
Mainardes, R. M.
Evangelista, R. C.
Título da Revista
ISSN da Revista
Título de Volume
Editor
Taylor & Francis Ltd
Resumo
Nanoparticles containing praziquantel made of Poly (D,L-lactide-co-glycolide) were designed by an emulsion-solvent evaporation method. Two organic solvents were separately utilized as disperse phase: methylene chloride and ethyl acetate. The size of the particles prepared with the former solvent was bigger than the particles prepared with the latter. The entrapment efficiency was bigger when methylene chloride was used, 79.82% in comparison with 29.27% by using ethyl acetate. DSC and infrared studies showed that no strong chemical interaction between drug and polymer occurred. Release kinetics of praziquantel, used as a model drug, was governed not only by actual drug loading but also by particles size. The higher the drug content and the smaller the particle size resulted in faster drug release.
Descrição
Palavras-chave
nanoparticles, controlled release, PLGA, praziquantel
Como citar
Journal of Microencapsulation. Abingdon: Taylor & Francis Ltd, v. 22, n. 1, p. 13-24, 2005.