Antimicrobial Brazilian propolis (EPP-AF) containing biocellulose membranes as promising biomaterial for skin wound healing
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2013-07-19
Autores
Barud, Hernane Da Silva [UNESP]
De Araújo Júnior, Adalberto Miguel [UNESP]
Saska, Sybele [UNESP]
Mestieri, Letícia Boldrin [UNESP]
Campos, Juliana Alvares Duarte Bonini [UNESP]
De Freitas, Rubens Moreno [UNESP]
Ferreira, Nathália Ursoli
Nascimento, Andresa Piacezzi
Miguel, Felipe Galeti
Vaz, Mirela Mara de Oliveira Lima Leite
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Among remarkable discoveries concerning propolis, such as antifungal, antiviral, and antioxidant activities, its anti-inflammatory, and mainly its antibacterial, properties deserve special attention when skin wound healing is concerned. Based on this and knowing the distinctive performance of bacterial (BC) membranes on wound healing, in this work it is proposed to demonstrate the potent antimicrobial activity and wound healing properties of a novel propolis containing biocellulose membrane. The obtained propolis/BC membrane was able to adsorb propolis not only on the surface, but also in its interstices demonstrated by scanning electron microscopy, X-ray diffraction, Fourier transform infrared (FT-IR) spectroscopy, and thermogravidimetric assays. Additionally, the polyphenolic compounds determination and the prominent antibacterial activity in the membrane are demonstrated to be dose dependent, supporting the possibility of obtaining propolis/BC membranes at the desired concentrations, taking into consideration its application and its skin residence time. Finally, it could be suggested that propolis/BC membrane may favor tissue repair in less time and more effectively in contaminated wounds. © 2013 Hernane da Silva Barud et al.
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antiinfective agent, polyphenol derivative, propolis, animal experiment, antimicrobial activity, bacterial membrane, Brazil, controlled study, drug determination, Fourier transform infrared photoacoustic spectroscopy, in vivo study, nonhuman, priority journal, scanning electron microscopy, skin injury, surface property, thermogravimetry, wound healing, X ray diffraction
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Evidence-based Complementary and Alternative Medicine, v. 2013.