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dc.contributor.authorCrossley II, Dane A.
dc.contributor.authorSartori, Marina R. [UNESP]
dc.contributor.authorAbe, Augusto S. [UNESP]
dc.contributor.authorTaylor, Edwin W. [UNESP]
dc.date.accessioned2014-05-27T11:30:04Z
dc.date.available2014-05-27T11:30:04Z
dc.date.issued2013-08-01
dc.identifierhttp://dx.doi.org/10.1007/s00360-013-0746-3
dc.identifier.citationJournal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology, v. 183, n. 6, p. 811-820, 2013.
dc.identifier.issn0174-1578
dc.identifier.urihttp://hdl.handle.net/11449/76103
dc.description.abstractA chorioallantoic membrane artery in embryos of the red-footed tortoise, Chelonoidis carbonaria was occlusively cannulated for measurement of blood pressure and injection of drugs. Two age groups of embryos in the final 10 % of incubation were categorized by the ratio of embryonic body to yolk mass. All embryos first received cholinergic and β-adrenergic blockade. This revealed that β-adrenergic control was established in both groups whereas cholinergic control was only established in the older group immediately prior to hatching. The study then progressed as two series. Series one was conducted in a subset of embryos treated with histamine before or after injection of ranitidine, the antagonist of H2 receptors. Injection of histamine caused an initial phasic hypertension which recovered, followed by a longer lasting hypertensive response accompanied by a tachycardia. Injection of the H2 receptor antagonist ranitidine itself caused a hypotensive tachycardia with subsequent recovery of heart rate. Ranitidine also abolished the cardiac effects of histamine injection while leaving the initial hypertensive response intact. In series, two embryos were injected with histamine after injection of diphenhydramine, the antagonist to H1 receptors. This abolished the whole of the pressor response to histamine injection but left the tachycardic response intact. These data indicate that histamine acts as a non-adrenergic, non-cholinergic factor, regulating the cardiovascular system of developing reptilian embryos and that its overall effects are mediated via both H1 and H2 receptor types. © 2013 Springer-Verlag Berlin Heidelberg.en
dc.format.extent811-820
dc.language.isoeng
dc.relation.ispartofJournal of Comparative Physiology B: Biochemical Systemic and Environmental Physiology
dc.sourceScopus
dc.subjectAdrenergic
dc.subjectCardiovascular
dc.subjectCholinergic
dc.subjectEmbryonic
dc.subjectHistamine
dc.subjectReptilia
dc.titleA role for histamine in cardiovascular regulation in late stage embryos of the red-footed tortoise, Chelonoidis carbonaria Spix, 1824en
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights
dc.contributor.institutionUniversity of North Texas
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversity of Birmingham
dc.description.affiliationDepartment of Biological Sciences, Developmental Integrative Biology Cluster University of North Texas, Denton, TX, 76203-5017
dc.description.affiliationDepartamento de Zoologia, Instituto de Biociências Universidade Estadual Paulista, Campus Rio Claro, São Paulo, SP
dc.description.affiliationSchool of Biosciences University of Birmingham, Birmingham, B15 2TT
dc.description.affiliationUnespDepartamento de Zoologia, Instituto de Biociências Universidade Estadual Paulista, Campus Rio Claro, São Paulo, SP
dc.identifier.doi10.1007/s00360-013-0746-3
dc.identifier.wosWOS:000322029200008
dc.rights.accessRightsAcesso restrito
dc.identifier.scopus2-s2.0-84880630102
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Rio Claropt
unesp.author.orcid0000-0003-3793-2955[2]
dc.relation.ispartofjcr2.517
dc.relation.ispartofsjr0,952
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