Simvastatin treatment increases nitrite levels in obese women: Modulation by T-786C polymorphism of eNOS
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Data
2013-08-13
Autores
Andrade, V. L.
Sertório, J. T. C.
Eleuterio, N. M.
Tanus-Santos, J. E.
Fernandes, K. S.
Sandrim, V. C. [UNESP]
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Resumo
Objective and Subjects: Evidence indicates an impairment of nitric oxide (NO) in obesity. Statins present pleiotropic effects independently of cholesterol-lowering, including increasing of eNOS expression and antioxidant effects. We evaluated the effects of simvastatin treatment at 45 days on circulating nitrite (NO marker) and TBARS-MDA levels in obese women without comorbidities (hypertension, diabetes and dyslipidemia). Moreover, we verified whether obese women carrying the C variant of T-786C polymorphism located in eNOS may have increased levels of nitrite after treatment compared to TT genotype. Results: After simvastatin treatment, while the plasma nitrite levels increased 42% (P = 0.0008), the TBARS-MDA levels reduced 58% (P = 0.0069). We observed increased levels of nitrite in both groups of genotypes (TT vs. TC + CC); however, rise in C-allele carriers was 60% comparing with 44% in TT. Conclusion: Our results demonstrated a restoration of nitrite levels in obese women treated with simvastatin, which is modulated by T-786C polymorphism. © 2013 Elsevier Inc. All rights reserved.
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ENOS, Nitrite, Obesity, Polymorphism, Statin
Como citar
Nitric Oxide - Biology and Chemistry, v. 33, p. 83-87.