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dc.contributor.authorAndrade, V. L.
dc.contributor.authorSertório, J. T. C.
dc.contributor.authorEleuterio, N. M.
dc.contributor.authorTanus-Santos, J. E.
dc.contributor.authorFernandes, K. S.
dc.contributor.authorSandrim, V. C. [UNESP]
dc.date.accessioned2014-05-27T11:30:09Z
dc.date.available2014-05-27T11:30:09Z
dc.date.issued2013-08-13
dc.identifierhttp://dx.doi.org/10.1016/j.niox.2013.07.005
dc.identifier.citationNitric Oxide - Biology and Chemistry, v. 33, p. 83-87.
dc.identifier.issn1089-8603
dc.identifier.issn1089-8611
dc.identifier.urihttp://hdl.handle.net/11449/76257
dc.description.abstractObjective and Subjects: Evidence indicates an impairment of nitric oxide (NO) in obesity. Statins present pleiotropic effects independently of cholesterol-lowering, including increasing of eNOS expression and antioxidant effects. We evaluated the effects of simvastatin treatment at 45 days on circulating nitrite (NO marker) and TBARS-MDA levels in obese women without comorbidities (hypertension, diabetes and dyslipidemia). Moreover, we verified whether obese women carrying the C variant of T-786C polymorphism located in eNOS may have increased levels of nitrite after treatment compared to TT genotype. Results: After simvastatin treatment, while the plasma nitrite levels increased 42% (P = 0.0008), the TBARS-MDA levels reduced 58% (P = 0.0069). We observed increased levels of nitrite in both groups of genotypes (TT vs. TC + CC); however, rise in C-allele carriers was 60% comparing with 44% in TT. Conclusion: Our results demonstrated a restoration of nitrite levels in obese women treated with simvastatin, which is modulated by T-786C polymorphism. © 2013 Elsevier Inc. All rights reserved.en
dc.format.extent83-87
dc.language.isoeng
dc.relation.ispartofNitric Oxide: Biology and Chemistry
dc.sourceScopus
dc.subjectENOS
dc.subjectNitrite
dc.subjectObesity
dc.subjectPolymorphism
dc.subjectStatin
dc.titleSimvastatin treatment increases nitrite levels in obese women: Modulation by T-786C polymorphism of eNOSen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institutionNúcleo de Pós-Graduação e Pesquisa - Santa Casa de Belo Horizonte
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.description.affiliationNúcleo de Pós-Graduação e Pesquisa - Santa Casa de Belo Horizonte, Rua Domingos Vieira 590, Belo Horizonte, MG
dc.description.affiliationDepartamento de Farmacologia Faculdade de Medicina de Ribeirão Preto Universidadede São Paulo, Av. Bandeirantes, 3900, Ribeirão Preto, SP
dc.description.affiliationDepartamento de Farmacologia Instituto de Biociências Universidade Estadual Paulista (UNESP), Botucatu, SP
dc.description.affiliationUnespDepartamento de Farmacologia Instituto de Biociências Universidade Estadual Paulista (UNESP), Botucatu, SP
dc.identifier.doi10.1016/j.niox.2013.07.005
dc.identifier.wosWOS:000324508400009
dc.rights.accessRightsAcesso aberto
dc.identifier.scopus2-s2.0-84881179229
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
dc.identifier.file2-s2.0-84881179229.pdf
unesp.author.orcid|0000-0002-6108-4004[1584]
unesp.author.orcid0000-0001-6576-9740[1389]
unesp.author.orcid0000-0003-2341-8330[1390]
unesp.author.orcid0000-0001-5848-005X[1395]
unesp.author.orcid0000-0001-7997-0306[708]
unesp.author.orcid0000-0003-0059-0779[1998]
unesp.author.orcid0000-0002-0227-1301[1162]
unesp.author.orcid0000-0003-1344-3356[1458]
unesp.author.orcid0000-0001-8731-160X[1708]
unesp.author.orcid0000-0002-6109-3023[1635]
unesp.author.orcid0000-0003-3273-9419[727]
unesp.author.orcid0000-0002-1194-8556[275]
unesp.author.orcid0000-0002-6976-4637[2064]
unesp.author.orcid0000-0002-2535-402X[537]
unesp.author.orcid0000-0002-8133-6467[909]
unesp.author.orcid0000-0001-7910-4109[1435]
unesp.author.orcid0000-0002-4974-8330[1121]
unesp.author.orcid0000-0002-5074-0539[1283]
unesp.author.orcid0000-0002-0429-2448[429]
unesp.author.orcid0000-0002-7088-8557[964]
unesp.author.orcid0000-0003-0217
dc.relation.ispartofjcr4.367
dc.relation.ispartofsjr1,278
dc.relation.ispartofsjr1,278
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