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dc.contributor.authorBonacorsi, Cibele
dc.contributor.authorDa Fonseca, Luiz Marcos [UNESP]
dc.contributor.authorRaddi, Maria Stella Gonçalves [UNESP]
dc.contributor.authorKitagawa, Rodrigo Rezende
dc.contributor.authorVilegas, Wagner [UNESP]
dc.date.accessioned2014-05-27T11:30:11Z
dc.date.available2014-05-27T11:30:11Z
dc.date.issued2013-08-20
dc.identifierhttp://dx.doi.org/10.1155/2013/851621
dc.identifier.citationEvidence-based Complementary and Alternative Medicine, v. 2013.
dc.identifier.issn1741-427X
dc.identifier.issn1741-4288
dc.identifier.urihttp://hdl.handle.net/11449/76294
dc.description.abstractTen Brazilian medicinal plants used to treat gastritis and ulcers were carefully selected on the basis of ethnopharmacological importance and antiulcerogenic activity previously described. The antioxidant activity of the methanolic extracts was determined in analysis conditions that simulate a real biological activity on inhibition of the oxidative burst induced in neutrophils using Helicobacter pylori as activator, by a luminol-amplified chemiluminescence assay. The extracts, at low concentration (5 g/mL), exhibited a large variation in inhibitory effects of H. pylori-induced oxidative burst ranging from 48% inhibition to inactive, but all extracts, excluding Byrsonima intermedia, had inhibitory activity over 80% at the concentration of 100 g/mL. The total suppressive antioxidant capacity measured as the effective concentration, which represents the extract concentration producing 50% inhibition of the chemiluminescence induced by H. pylori, varies from 27.2 to 56.8 g/mL and was in the following order: Qualea parviflora > Qualea multiflora > Alchornea triplinervia > Qualea grandiflora > Anacardium humile > Davilla elliptica > Mouriri pusa > Byrsonima basiloba > Alchornea glandulosa > Byrsonima intermedia. The main groups of compounds in tested extracts are presented. Differences in the phytochemical profile, quantitatively and qualitatively, of these plants can explain and justify their protective effect on the gastric mucosa caused by the neutrophil-generated ROS that occurs when H. pylori displays its evasion mechanisms. © 2013 Cibele Bonacorsi et al.en
dc.language.isoeng
dc.relation.ispartofEvidence-based Complementary and Alternative Medicine
dc.sourceScopus
dc.subjectAlchornea glandulosa extract
dc.subjectAlchornea triplinervia extract
dc.subjectAnacardium humile extract
dc.subjectantioxidant
dc.subjectByrsonima basiloba extract
dc.subjectByrsonima intermedia extract
dc.subjectDavilla elliptica extract
dc.subjectMouriri pusa extract
dc.subjectplant extract
dc.subjectQualea grandiflora extract
dc.subjectQualea multiflora extract
dc.subjectQualea parviflora extract
dc.subjectunclassified drug
dc.subjectAlchornea glandulosa
dc.subjectAlchornea triplinervia
dc.subjectAnacardium humile
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectantioxidant activity
dc.subjectbacterium culture
dc.subjectBrazil
dc.subjectByrsonima basiloba
dc.subjectByrsonima intermedia
dc.subjectcell viability
dc.subjectchemoluminescence
dc.subjectcontrolled study
dc.subjectDavilla elliptica
dc.subjectgastritis
dc.subjectHelicobacter pylori
dc.subjectmale
dc.subjectmedicinal plant
dc.subjectMouriri pusa
dc.subjectneutrophil
dc.subjectnonhuman
dc.subjectperitoneum exudate
dc.subjectpriority journal
dc.subjectQualea grandiflora
dc.subjectQualea multiflora
dc.subjectQualea parviflora
dc.subjectrat
dc.subjectrespiratory burst
dc.subjectstomach ulcer
dc.titleComparison of Brazilian plants used to treat gastritis on the oxidative burst of helicobacter pylori -stimulated neutrophilen
dc.typeArtigo
dcterms.licensehttp://www.hindawi.com/journals/aaa/guidelines/
dc.contributor.institutionUniversidade Federal de Mato Grosso
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal do Espírito Santo (UFES)
dc.description.affiliationInstituto de Ciências da Saúde Universidade Federal de Mato Grosso, 78557-267 Sinop, MT
dc.description.affiliationFaculdade de Ciências Farmacêuticas Universidade Estadual Paulista (UNESP), 14801-902 Araraquara, SP
dc.description.affiliationDepartamento de Ciências Farmacêuticas Universidade Federal Do Espírito Santo, 29040-090 Vitória, ES
dc.description.affiliationCampus Experimental Do Litoral Paulista Universidade Estadual Paulista (UNESP), 11330-900 São Vicente, SP
dc.description.affiliationUnespFaculdade de Ciências Farmacêuticas Universidade Estadual Paulista (UNESP), 14801-902 Araraquara, SP
dc.description.affiliationUnespCampus Experimental Do Litoral Paulista Universidade Estadual Paulista (UNESP), 11330-900 São Vicente, SP
dc.identifier.doi10.1155/2013/851621
dc.identifier.wosWOS:000322470100001
dc.rights.accessRightsAcesso aberto
dc.identifier.scopus2-s2.0-84881494907
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, São Vicentept
dc.identifier.file2-s2.0-84881494907.pdf
dc.identifier.lattes7927877224326837
dc.identifier.orcid0000-0003-3032-2556
unesp.author.lattes7927877224326837
unesp.author.orcid0000-0003-3032-2556[5]
dc.relation.ispartofjcr2.064
dc.relation.ispartofsjr0,683
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