Evaluation of Syngonanthus nitens (Bong.) Ruhl. extract as antifungal and in treatment of vulvovaginal candidiasis
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Data
2013-10-01
Autores
De Freitas Araújo, Marcelo Gonzaga [UNESP]
Pacífico, Mariana
Vilegas, Wagner [UNESP]
Dos Santos, Lourdes Campaner
Icely, Paula Alejandra
Miró, Maria Soledad
Scarpa, Maria Virginia Costa [UNESP]
Bauab, Taís Maria [UNESP]
Sotomayor, Claudia Elena
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Resumo
The purpose of this study was to evaluate the in vitro anticandidal activity of a methanolic extract of Syngonanthus nitens scapes against different Candida species and clinical isolates from patients with vulvovaginal candidiasis (VVC), and its effect in vivo in the treatment of vaginal infection. Chemical characterization of the extract was performed by HPLC-UV analyses and showed the presence of flavones derivatives. The extract was effective against several Candida strains from our collection and species recovered from VVC patients, and was able to inhibit the yeast-hyphal transition. No cytotoxic activity against human female reproductive tract epithelial cells and no hemolytic activity against human red blood cells were observed. In the in vivo model of VVC, we evaluated the efficacy of the intravaginal treatment with a cream containing the extract at doses of 0.5, 1.0 and 2.0%. The treatment eradicated the vaginal fungal burden in infected rats after 8 days of treatment. S. nitens extract could be considered as an effective and non-toxic natural antifungal agent in the treatment of vulvovaginal candidiasis. © 2013 ISHAM.
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Anticandidal activity, Syngonanthus nitens, Vulvovaginal candidiasis, Yeast-hyphal transition, amphotericin B, antifungal agent, flavone derivative, flavonoid, plant extract, Syngonanthus nitens extract, unclassified drug, animal experiment, animal model, antifungal activity, antifungal susceptibility, Candida albicans, Candida krusei, Candida parapsilosis, Candida tropicalis, cell damage, controlled study, cream, drug cytotoxicity, drug efficacy, epithelium cell, Eriocaulaceae, erythrocyte, evaluation, female, female genital system, fungus growth, growth inhibition, hemolysis, high performance liquid chromatography, human, human cell, in vitro study, minimum inhibitory concentration, nonhuman, rat, ultraviolet spectroscopy, vagina candidiasis, vaginitis
Como citar
Medical Mycology, v. 51, n. 7, p. 673-682, 2013.