RSS 1.0Artigos - Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP) - Botucatu
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Isolation and Functional Characterization of an Acidic Myotoxic Phospholipase A₂ from Colombian Bothrops asper Venom
(Toxins, 2017) [Artigo]Myotoxic phospholipases A₂ (PLA₂) are responsible for many clinical manifestations in envenomation by Bothrops snakes. A new myotoxic acidic Asp49 PLA₂ (BaCol PLA₂) was isolated from Colombian Bothrops asper venom using ... -
Long-Standing Motor and Sensory Recovery following Acute Fibrin Sealant Based Neonatal Sciatic Nerve Repair
(Neural plasticity, 2016) [Artigo]Brachial plexus lesion results in loss of motor and sensory function, being more harmful in the neonate. Therefore, this study evaluated neuroprotection and regeneration after neonatal peripheral nerve coaptation with ... -
Reviewer acknowledgement 2015
(Journal of Venomous Animals and Toxins Including Tropical Diseases, 2016) [Artigo]The Editor of Journal of Venomous Animals and Toxins including Tropical Diseases would like to thank all of our reviewers, both external and Editorial Board Members, who have contributed to the journal in Volume 21 (2015) ... -
BjSP, a novel serine protease from Bothrops jararaca snake venom that degrades fibrinogen without forming fibrin clots
; ; ; ; ; da Silva, Ronivaldo R.
; ; Barraviera, Benedito ; Ferreira Junior, Rui S. ; (Toxicology and Applied Pharmacology, 2018) [Artigo]
Snake venom serine proteases (SVSPs) are commonly described as capable of affecting hemostasis by interacting with several coagulation system components. In this study, we describe the isolation and characterization of ... -
Serological proteomic biomarkers to identify Paracoccidioides species and risk of relapse
Sylvestre, Tatiane Fernanda; Cavalcante, Ricardo de Souza ; Da Silva, Julhiany de Fátima ; ; ; ; Carvalho, Lídia Raquel de ; Dos Santos, Lucilene Delazari ; Mendes, Rinaldo Poncio (PLoS ONE, 2018) [Artigo]
The sensitivity of the double agar gel immunodiffusion test is about 90% in patients with untreated paracoccidioidomycosis (PCM), but it is much lower in cases of relapse. In addition, serum from patients with PCM caused ... -
Neuroprotection and immunomodulation following intraspinal axotomy of motoneurons by treatment with adult mesenchymal stem cells
; ; ; ; Ferreira, R. S.; Barraviera, B. ; (Journal of Neuroinflammation, 2018) [Artigo]
Background: Treatment of spinal cord injury is dependent on neuronal survival, appropriate synaptic circuit preservation, and inflammatory environment management. In this sense, mesenchymal stem cell (MSC) therapy is a ... -
Current advances in immunological studies on the vespidae venom antigen 5: Therapeutic and prophylaxis to hypersensitivity responses
Bazon, Murilo Luiz; Silveira, Lais Helena ; ; Brochetto-Braga, Márcia Regina (Toxins, 2018) [Resenha]
Although systemic reactions caused by allergenic proteins present in venoms affect a small part of the world population, Hymenoptera stings are among the main causes of immediate hypersensitivity responses, with risk of ... -
Toxicity and motor changes in africanized honey bees (Apis mellifera l.) exposed to fipronil and imidacloprid
Bovi, Thaís S.; Zaluski, Rodrigo ; Orsi, Ricardo de Oliveira (Anais da Academia Brasileira de Ciencias, 2018) [Artigo]
This study evaluated the in vitro toxicity and motor activity changes in African-derived adult honey bees (Apis mellifera L.) exposed to lethal or sublethal doses of the insecticides fipronil and imidacloprid. Mortality ... -
Combination of heterologous fibrin sealant and bioengineered human embryonic stem cells to improve regeneration following autogenous sciatic nerve grafting repair
; ; ; Ferreira, Rui Seabra; Barraviera, Benedito ; (Journal of Venomous Animals and Toxins Including Tropical Diseases, 2018) [Artigo]
Background: Peripheral nerve injury is a worldwide clinical problem, and the preferred surgical method for treating it is the end-to-end neurorrhaphy. When it is not possible due to a large nerve gap, autologous nerve ... -
Molecular identification and phylogenetic analysis of Bothrops insularis bacterial and fungal microbiota
Barbosa, Lidiane Nunes; Ferreira, Rui Seabra ; Luiza Mello, Priscila ; Garcia Garces, Hans ; Luana Chechi, Jéssica ; Frachin, Tarsila ; De Barros, Luciana Curtolo ; De Moraes Guimenes Bosco, Sandra ; Bagagli, Eduardo ; Fernandes Júnior, Ary et al. (Journal of Toxicology and Environmental Health - Part A: Current Issues, 2018) [Artigo]
Bothrops insularis, known as the golden lancehead snake, has its natural habitat restricted to Queimada Grande Island on the southern coast of Brazil. This culture-dependent study aimed to identify microorganisms obtained ... -
Crotalus durissus terrificus crotapotin naturally displays preferred positions for amino acid substitutions
de Oliveira, Laudicéia Alves; Ferreira, Rui Seabra ; Barraviera, Benedito ; de Carvalho, Francilene Capel Tavares ; de Barros, Luciana Curtolo ; dos Santos, Lucilene Delazari ; Pimenta, Daniel Carvalho (Journal of Venomous Animals and Toxins Including Tropical Diseases, 2017) [Artigo]
Background: Classically, Crotalus durissus terrificus (Cdt) venom can be described, according to chromatographic criteria, as a simple venom, composed of four major toxins, namely: gyroxin, crotamine, crotoxin and convulxin. ... -
Phospholipase A1-based cross-reactivity among venoms of clinically relevant Hymenoptera from Neotropical and temperate regions
Perez-Riverol, Amilcar; ; ; dos Santos-Pinto, José Roberto Aparecido ; ; Izuka Moraes, Gabriel Hideki ; ; ; ; Palma, Mario Sergio et al. (Molecular Immunology, 2018) [Artigo]
Molecular cross-reactivity caused by allergen homology or cross-reactive carbohydrate determinants (CCDs) is a major challenge for diagnosis and immunotherapy of insect venom allergy. Venom phospholipases A1 (PLA1s) are ... -
Who has anaphylaxis in Brazil? Validation of a questionnaire for population studies
; Delazari Dos Santos, Lucilene; Gomes De Pontes, Leticia ; (World Allergy Organization Journal, 2017) [Artigo]
Background: The incidence of anaphylaxis is increasing in several parts of the world; thus, determining the prevalence of the disease in a given region is important to understand the factors involved and to promote measures ... -
Isolation and functional characterization of an acidic myotoxic phospholipase A2 from colombian Bothrops asper venom
; ; ; ; ; dos Santos, Lucilene Delazari; Ferreira, Rui Seabra ; (Toxins, 2017) [Artigo]
Myotoxic phospholipases A2 (PLA2) are responsible for many clinical manifestations in envenomation by Bothrops snakes. A new myotoxic acidic Asp49 PLA2 (BaCol PLA2) was isolated from Colombian Bothrops asper venom using ... -
A unique heterologous fibrin sealant (HFS) as a candidate biological scaffold for mesenchymal stem cells in osteoporotic rats
Orsi, Patrícia Rodrigues; Landim-Alvarenga, Fernanda Cruz ; Justulin, Luis Antônio ; Kaneno, Ramon ; De Assis Golim, Marjorie ; Dos Santos, Daniela Carvalho ; Creste, Camila Fernanda Zorzella ; Oba, Eunice ; Maia, Leandro ; Barraviera, Benedito et al. (Stem Cell Research and Therapy, 2017) [Artigo]
Background: The injection of mesenchymal stem cells (MSCs) directly into the bone of osteoporotic (OP) patients for rapid recovery has been studied worldwide. Scaffolds associated with MSCs are used to maintain and avoid ... -
Heterologous expression, purification and immunoreactivity of the antigen 5 from polybia paulista wasp venom
Bazon, Murilo Luiz; Perez-Riverol, Amilcar ; Dos Santos-Pinto, José Roberto Aparecido ; ; ; Justo-Jacomini, Débora Laís ; Palma, Mario Sergio ; ; Brochetto-Braga, Márcia Regina (Toxins, 2017) [Artigo]
Polybia paulista (Hymenoptera: Vespidae) is responsible for a high number of sting accidents and anaphylaxis events in Southeast Brazil, Argentina and Paraguay. The specific detection of allergy to the venom of this wasp ... -
Stimulation of morphofunctional repair of the facial nerve with photobiomodulation, using the end-to-side technique or a new heterologous fibrin sealant
(Journal of Photochemistry and Photobiology B: Biology, 2017) [Artigo]This research evaluated the influence of Photobiomodulation Therapy (PBMT) on lesions of the facial nerve repaired with the end-to-side technique or coaptation with a new heterologous fibrin sealant. Thirty-two Wistar rats ... -
Efficacy of Laser Photobiomodulation on Morphological and Functional Repair of the Facial Nerve
; ; Ferreira Junior, Rui Seabra; Barraviera, Benedito ; ; ; ; ; ; et al. (Photomedicine and Laser Surgery, 2017) [Artigo]
Objective: Evaluate the efficacy of low-level laser therapy (LLLT) on qualitative, quantitative, and functional aspects in the facial nerve regeneration process. Materials and methods: Forty-two male Wistar rats were used, ... -
Plasma proteome of buffaloes
de Pontes, Leticia Gomes; Cavassan, Nayara Rodrigues Vieira ; de Barros, Luciana Curtolo ; Ferreira Junior, Rui Seabra ; Barraviera, Benedito ; Santos, Lucilene Delazari dos (Proteomics - Clinical Applications, 2017) [Artigo]
The proteomic approach has aroused the interest of veterinary medicine researchers, especially regarding the production of biopharmaceuticals and diagnosis of diseases in farm animals. Water buffaloes have gained prominence ... -
Wasp venomic: Unravelling the toxins arsenal of Polybia paulista venom and its potential pharmaceutical applications
Perez-Riverol, Amilcar; dos Santos-Pinto, José Roberto Aparecido ; ; Palma, Mario Sergio ; Brochetto-Braga, Márcia Regina (Journal of Proteomics, 2017) [Resenha]
Polybia paulista (Hymenoptera: Vespidae) is a neotropical social wasp from southeast Brazil. As most social Hymenoptera, venom from P. paulista comprises a complex mixture of bioactive toxins ranging from low molecular ...