• Launching a CDMO in Brazil aiming to develop biopharmaceuticals for clinical trials 

  Ferreira Junior, Rui Seabra ; Morales, Marcelo Marcos; Barretti, Pasqual ; Barraviera, Benedito (Journal of Venomous Animals and Toxins Including Tropical Diseases, 2022) [Artigo]

  The innovation timeline is expensive, risky, competitive, time-consuming, and laborintensive. In order to overcome such challenges and optimize financial resources, pharmaceutical companies nowadays hire contract development ...

• Effects of a Biocomplex Formed by Two Scaffold Biomaterials, Hydroxyapatite/Tricalcium Phosphate Ceramic and Fibrin Biopolymer, with Photobiomodulation, on Bone Repair 

  Reis, Carlos Henrique Bertoni; Buchaim, Rogerio Leone; Pomini, Karina Torres; Hamzé, Abdul Latif; Zattiti, Isabella Vasconcelos; Duarte, Marco Antonio Hungaro; Alcalde, Murilo Priori; Barraviera, Benedito ; Ferreira Júnior, Rui Seabra ; Pontes, Fenelon Martinho Lima et al. (Polymers, 2022) [Artigo]

  There are several treatment methods available for bone repair, although the effectiveness becomes limited in cases of large defects. The objective of this pre-clinical protocol was to evalu-ate the grafting of hydroxyapa ...

• Using of Fibrin Sealant on Treatment for Tendon Lesion: Study in Vivo 

  Dutra Junior, Enéas de Freitas; Hidd, S. M.C.M.; Amaral, M. M.; Maia Filho, A. L.M.; Assis, L.; Ferreira, R. S. ; Barraviera, B. ; Tim, C. R. (IFMBE Proceedings, 2022) [Trabalho apresentado em evento]

  Tendon injuries are among the most common orthopaedic problems with long-term disability as a frequent consequence due to its prolonged healing time. Thus, the study has investigated the effect a new fibrin sealant (FS) ...

• The Heterologous Fibrin Sealant and Aquatic Exercise Treatment of Tendon Injury in Rats 

  Hidd, S. M.C.M.; Dutra, E. F.; Tim, C. R.; Filho, A. L.M.M.; Assis, L.; Ferreira, R. S. ; Barraviera, B. ; Amaral, M. M. (IFMBE Proceedings, 2022) [Trabalho apresentado em evento]

  Acute rupture of the calcaneus tendon is relatively common, usually related to sports practice. In recent years, the number of researches in search of more efficient techniques, which induce the healing process, has been ...

• A biocomplex to repair experimental critical size defects associated with photobiomodulation therapy 

  Buchaim, Daniela Vieira ; Andreo, Jesus Carlos; Pomini, Karina Torres; Barraviera, Benedito ; Ferreira, Rui Seabra ; Duarte, Marco Antonio Hungaro; Alcalde, Murilo Priori; Reis, Carlos Henrique Bertoni; de Bortoli Teixeira, Daniel; de Souza Bueno, Cleuber Rodrigo et al. (Journal of Venomous Animals and Toxins Including Tropical Diseases, 2022) [Artigo]

  Background: The association of scaffolds to repair extensive bone defects can contribute to their evolution and morphophysiological recomposition. The incorporation of particulate biomaterials into three-dimensional fibrin ...

• A fingerprint of plasma proteome alteration after local tissue damage induced by Bothrops leucurus snake venom in mice 

  Cavalcante, Joeliton dos Santos ; de Almeida, Cayo Antônio Soares; Clasen, Milan Avila; da Silva, Emerson Lucena; de Barros, Luciana Curtolo ; Marinho, Aline Diogo; Rossini, Bruno Cesar ; Marino, Celso Luís ; Carvalho, Paulo Costa; Jorge, Roberta Jeane Bezerra et al. (Journal of Proteomics, 2022) [Artigo]

  Bothrops spp. is responsible for about 70% of snakebites in Brazil, causing a diverse and complex pathophysiological condition. Bothrops leucurus is the main species of medical relevance found in the Atlantic coast in the ...

• Variant expression signatures of microRNAs and protein related to growth in a crossbreed between two strains of Nile tilapia (Oreochromis niloticus) 

  Herkenhoff, Marcos Edgar ; Bovolenta, Luiz A. ; Broedel, Oliver; dos Santos, Lucilene D. ; de Oliveira, Arthur C. ; Chuffa, Luiz G.A. ; Ribeiro, Amanda de O. ; Lupi, Luiz A. ; Dias, Marco A.D.; Hilsdorf, Alexandre W.S. et al. (Genomics, 2021) [Artigo]

  Nile tilapia (Oreochromis niloticus) is a species of worldwide importance for aquaculture. A crossbred lineage was developed through introgressive backcross breeding techniques and combines the high growth performance of ...

• Phosphodiesterase-5 inhibitor sildenafil attenuates kidney injury induced by Bothrops alternatus snake venom 

  Jorge, Antônio Rafael Coelho; Marinho, Aline Diogo; Silveira, João Alison de Moraes; Nogueira Junior, Francisco Assis; de Aquino, Pedro Everson Alexandre; Alves, Ana Paula Negreiros Nunes; Jorge, Roberta Jeane Bezerra; Ferreira Junior, Rui Seabra ; Monteiro, Helena Serra Azul (Toxicon, 2021) [Artigo]

  Acute kidney injury pathogenesis in envenoming by snakes is multifactorial and involves immunologic reactions, hemodynamic disturbances, and direct nephrotoxicity. Sildenafil (SFC), a phosphodiesterase 5 inhibitor, has ...

• Crotoxin: A novel allergen to occupational anaphylaxis 

  De Pontes, Leticia Gomes ; Cavassan, Nayara Rodrigues Vieira ; Creste, Camila Fernanda Zorzella ; Junior, Airton Lourenço ; Arcuri, Helen Andrade ; Ferreira, Rui Seabra ; Barraviera, Benedito ; Gagete, Elaine; Dos Santos, Lucilene Delazari (Annals of Allergy, Asthma and Immunology, 2016) [Artigo]

• Influência das fases de anestro e diestro na competência meiótica oocitária de cadelas 

  Pereira, Leda Maria Costa ; Bersano, Paulo Ricardo de Oliveira ; Lima, Alfredo Feio da Maia ; Pantoja, José Carlos de Figueiredo ; Lopes, Maria Denise (Brazilian Journal of Veterinary Research and Animal Science, 2015) [Artigo]

  The bitch has reproductive peculiarities that differentiate it from other species. Several experiments have been conducted to establish efficient protocols for maturation; however, the results appear to be unsatisfactory. ...

• Influência da temperatura de transporte de ovários na maturação in vitro de oócitos caninos coletados em diferentes estágios do ciclo estral 

  Pereira, Leda Maria Costa ; De Bersano, P. R. ; Lopes, Maria Denise (Brazilian Journal of Veterinary Research and Animal Science, 2015) [Artigo]

  This study evaluated the influence of estrous cycle stage and transport temperature of ovaries on in vitro maturation of canine oocytes. The bitches were categorized into two groups based on stage of estrus cycle: diestrus ...

• Individual venom profiling of Crotalus durissus terrificus specimens from a geographically limited region: Crotamine assessment and captivity evaluation on the biological activities 

  Lourenço, Airton ; Zorzella Creste, Camila Fernanda ; Curtolo de Barros, Luciana ; Delazari dos Santos, Lucilene ; Pimenta, Daniel C. ; Barraviera, Benedito ; Ferreira, Rui Seabra (Toxicon, 2013) [Artigo]

  Crotalus durissus terrificus (Cdt) venom major components comprise crotoxin, crotamine, gyroxin and convulxin. Crotamine exerts a myotoxic action, among others, but its expression varies even amid snakes from the same ...

• The first reported case of human tick paralysis in Brazil: A new induction pattern by immature stages 

  Almeida, Ricardo Augusto Monteiro de Barros ; Ferreira, M. A. ; Barraviera, B. ; Haddad, V. (Journal of Venomous Animals and Toxins Including Tropical Diseases, 2012) [Artigo]

  Tick paralysis (TP) is a rare disease with rapid progression and potential fatal evolution. Immediately after the diagnosis, removal of all ticks from the body of the patient is mandatory. The present study reports for the ...

• Toxinology and Brazil: A close connection 

  Ferreira Jr., Rui Seabra (Journal of Venomous Animals and Toxins Including Tropical Diseases, 2012) [Artigo]

• Who communicates with whom? 

  Santos, L. D. (Journal of Venomous Animals and Toxins Including Tropical Diseases, 2012) [Artigo]

• A new scenario of bioprospecting of Hymenoptera venoms through proteomic approach 

  Santos, L. D. ; Pieroni, M.; Menegasso, A. R.S. ; Pinto, J. R.A.S. ; Palma, M. S. (Journal of Venomous Animals and Toxins Including Tropical Diseases, 2011) [Resenha]

  Venoms represent a huge and essentially unexplored reservoir of bioactive components that may cure diseases that do not respond to currently available therapies. This review select advances reported in the literature from ...

• Ovine leptospirosis in Brazil 

  Lucheis, S. B.; Ferreira, Jr. (Journal of Venomous Animals and Toxins Including Tropical Diseases, 2011) [Artigo]

  Leptospirosis is a zoonosis distributed worldwide, endemic mainly in humid subtropical and tropical countries, with epidemic potential. It affects a range of both wild and domestic animals, including sheep, which transport ...

• How to overcome the gap between basic research and clinical trials? 

  Barraviera, B. (Journal of Venomous Animals and Toxins Including Tropical Diseases, 2011) [Editorial]

• Treatment of venous ulcers with fibrin sealant derived from snake venom 

  Gatti, M. A.N.; Vieira, L. M.; Barraviera, B. ; Barraviera, S. R.C.S. (Journal of Venomous Animals and Toxins Including Tropical Diseases, 2011) [Artigo]

  Venous ulcers of the lower limbs complicated by infection or chronicity represent a serious public health problem. The elevated number of those afflicted burdens the health services, interferes in quality of life and causes ...

• Universities and neglected diseases - It is not enough to have the knowledge, it must be applied 

  Caramori, C. A. ; Barraviera, B. (Journal of Venomous Animals and Toxins Including Tropical Diseases, 2011) [Editorial]

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