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dc.contributor.authorMoroz, Andrei[UNESP]
dc.contributor.authorDeffune, Elenice [UNESP]
dc.date.accessioned2014-05-27T11:30:52Z
dc.date.available2014-05-27T11:30:52Z
dc.date.issued2013-11-01
dc.identifierhttp://dx.doi.org/10.1016/j.jcyt.2013.05.019
dc.identifier.citationCytotherapy, v. 15, n. 11, p. 1436-1439, 2013.
dc.identifier.issn1465-3249
dc.identifier.issn1477-2566
dc.identifier.urihttp://hdl.handle.net/11449/76898
dc.description.abstractBackground: Platelet-rich plasma has been largely used as a therapeutic option for the treatment of chronic wounds of different etiologies. The enhanced regeneration observed after the use of platelet-rich plasma has been systematically attributed to the growth factors that are present inside platelets' granules. Aim: We hypothesize that the remaining plasma and platelet-bound fibronectin may act as a further bioactive protein in platelet-rich plasma preparations. Methods: Recent reports were analyzed and presented as direct evidences of this hypotheses. Results: Fibronectin may directly influence the extracellular matrix remodeling during wound repair. This effect is probably through matrix metalloproteinase expression, thus exerting an extra effect on chronic wound regeneration. Conclusions: Physicians should be well aware of the possible fibronectin-induced effects in their future endeavors with PRP in chronic wound treatment. © 2013 International Society for Cellular Therapy.en
dc.format.extent1436-1439
dc.language.isoeng
dc.relation.ispartofCytotherapy
dc.sourceScopus
dc.subjectChronic wounds
dc.subjectExtracellular matrix
dc.subjectFibronectin
dc.subjectMMP
dc.subjectPlatelet-rich plasma
dc.subjectPRP
dc.subjectWound regeneration
dc.titlePlatelet-Rich Plasma And Chronic Wounds: Remaining Fibronectin May Influence Matrix Remodeling And Regeneration Successen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationBlood Transfusion Center, Cell Engineering Laboratory Botucatu Medical School Universidade Estadual Paulista-UNESP, Botucatu, SP
dc.description.affiliationDepartment of Morphology, Extracellular Matrix Laboratory Botucatu Biosciences Institute Universidade Estadual Paulista-UNESP, Botucatu, SP
dc.description.affiliationDepartment of Urology, Botucatu Medical School Universidade Estadual Paulista-UNESP, Botucatu, SP
dc.description.affiliationUnespBlood Transfusion Center, Cell Engineering Laboratory Botucatu Medical School Universidade Estadual Paulista-UNESP, Botucatu, SP
dc.description.affiliationUnespDepartment of Morphology, Extracellular Matrix Laboratory Botucatu Biosciences Institute Universidade Estadual Paulista-UNESP, Botucatu, SP
dc.description.affiliationUnespDepartment of Urology, Botucatu Medical School Universidade Estadual Paulista-UNESP, Botucatu, SP
dc.identifier.doi10.1016/j.jcyt.2013.05.019
dc.identifier.wosWOS:000325732800013
dc.rights.accessRightsAcesso restrito
dc.identifier.scopus2-s2.0-84884979717
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
dc.identifier.lattes9646764071339214
unesp.author.lattes9646764071339214
unesp.author.lattes6926124203948011[1]
unesp.author.orcid0000-0002-0533-3248[2]
unesp.author.orcid0000-0002-4498-9784[1]
dc.relation.ispartofjcr3.993
dc.relation.ispartofsjr1,144
dc.relation.ispartofsjr1,144
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