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dc.contributor.authorDevienne, K. F.
dc.contributor.authorRaddi, MSG
dc.contributor.authorCoelho, R. G.
dc.contributor.authorVilegas, Wagner [UNESP]
dc.date.accessioned2014-05-20T13:24:39Z
dc.date.available2014-05-20T13:24:39Z
dc.date.issued2005-05-01
dc.identifierhttp://dx.doi.org/10.1016/j.phymed.2003.09.010
dc.identifier.citationPhytomedicine. Jena: Urban & Fischer Verlag, v. 12, n. 5, p. 378-381, 2005.
dc.identifier.issn0944-7113
dc.identifier.urihttp://hdl.handle.net/11449/7713
dc.description.abstractThree naturally occurring isocoumarins (paepalantine, paepalantine 9-O-beta-D-glucopyranoside and paepalantine 90-beta-D-allopyranosyl(1 -> 6) glucopyranoside) and two semi-synthetic analogues, 9,10-acylated compound and 9-OH-10-methylated compound,. structurally similar to paepalantine, were evaluated for antimicrobial activity using a spectrophotometric microdilution technique. The paepalantine was active against S. aureus, S. epidermidis, and E faecalis. while the other four compounds proved ineffective against all microorganisms tested at concentrations of 500 mu g/ml. Variations in phenolic substitution at OH-9 and/or OH-10 in the paepalantine molecule resulted in compounds without antimicrobial activity. A combination of structural features, two phenolic groups as cathecolic system, forms an oxygenated system arrangement that may reflect the potentially antimicrobial properties of paepalantine. (c) 2004 Elsevier GmbH. All rights reserved.en
dc.format.extent378-381
dc.language.isoeng
dc.publisherUrban & Fischer Verlag
dc.relation.ispartofPhytomedicine
dc.sourceWeb of Science
dc.subjectantimicrobial activitypt
dc.subjectnatural isocournarins of Eriocaqulaceae familypt
dc.titleStructure-antimicrobial activity of some natural isocoumarins and their analoguesen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderUrban & Fischer Verlag
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.description.affiliationUniv Estadual Paulista, Fac Ciências Farmaceut Araraquara, São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Inst Quim Araraquara, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciências Farmaceut Araraquara, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Quim Araraquara, São Paulo, Brazil
dc.identifier.doi10.1016/j.phymed.2003.09.010
dc.identifier.wosWOS:000230192100009
dc.rights.accessRightsAcesso restrito
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, São Vicentept
dc.identifier.lattes7927877224326837
dc.identifier.orcid0000-0003-3032-2556
unesp.author.lattes7927877224326837
unesp.author.orcid0000-0003-3032-2556[4]
dc.relation.ispartofjcr3.610
dc.relation.ispartofsjr1,087
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