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dc.contributor.authorLopes, Cristiani C. G. O. [UNESP]
dc.contributor.authorSalgado, Hérida Regina Nunes [UNESP]
dc.date.accessioned2014-05-20T13:24:47Z
dc.date.available2014-05-20T13:24:47Z
dc.date.issued2009-06-01
dc.identifierhttp://dx.doi.org/10.1365/s10337-009-0993-3
dc.identifier.citationChromatographia. Wiesbaden: Vieweg, v. 69, p. 129-135, 2009.
dc.identifier.issn0009-5893
dc.identifier.urihttp://hdl.handle.net/11449/7790
dc.description.abstractThis paper describes the validation of an isocratic LC method for the assay of linezolid in tablets. Validation parameters such as linearity, precision, accuracy, specificity, limit of detection, limit of quantitation and robustness were determined. LC was carried out by reversed phase technique on an RP-18 column with a mobile phase composed of 1% acetic acid:methanol:acetonitrile (50:25:25, v/v/v). Linezolid and your combination drug product were exposed to acid, base, oxidation, dry heat and photolytic stress conditions. A linear response (r > 0.9999) was observed in the range of 8.0-20.0 mu g mL(-1). The retention time of linezolid was 4.6 min. The method showed good recoveries and intra- and inter-day relative standard deviations were less than 1.0%. The LOD and LOQ were 0.21 and 0.63 mu g mL(-1), respectively. The developed LC method for determination of related substances and assay determination of linezolid can be used to evaluate the quality of regular production samples. It can also be used to test the stability samples of linezolid.en
dc.description.sponsorshipPACD-FCFAr-UNESP (Araraquara, Brazil)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipFUND-UNESP (São Paulo, Brazil)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent129-135
dc.language.isoeng
dc.publisherVieweg
dc.relation.ispartofChromatographia
dc.sourceWeb of Science
dc.subjectColumn liquid chromatographyen
dc.subjectValidationen
dc.subjectLinezoliden
dc.titleDevelopment of a Validated Stability-Indicating LC Assay and Stress Degradation Studies of Linezolid in Tabletsen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderVieweg
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.description.affiliationUniv Estadual Paulista, Dept Farmacos & Medicamentos, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Farmacos & Medicamentos, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil
dc.identifier.doi10.1365/s10337-009-0993-3
dc.identifier.wosWOS:000267330400005
dc.rights.accessRightsAcesso restrito
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.author.orcid0000-0002-8120-2362[1]
unesp.author.orcid0000-0002-0385-340X[2]
dc.relation.ispartofjcr1.401
dc.relation.ispartofsjr0,514
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