Tigecycline: A Review of Properties, Applications, and Analytical Methods

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Data

2010-06-01

Autores

da Silva, Lucelia Magalhaes [UNESP]
Salgado, Hérida Regina Nunes [UNESP]

Título da Revista

ISSN da Revista

Título de Volume

Editor

Lippincott Williams & Wilkins

Resumo

Tigecycline is a new glycylcycline with an expanded broad-spectrum antibiotic, including inhibition of Gram-positive, Gram-negative, atypical, anaerobic, and antibiotic-resistant organisms. Trials have demonstrated that tigecycline is noninferior to the comparators for the treatment of complicated skin and skin structure infections as well as complicated intra-abdominal infections. Tigecycline is only available as an intravenous preparation and analytical methods to its quantitation in pharmaceutical products has not been published to date. This review examined tigecycline characteristics, the spectrum and mechanism of action, pharmacokinetics, applications, and, mainly, the instrumental conditions of published chromatographic methods used to measure tigecycline, its metabolites, and some analogs in clinical and biologic research.

Descrição

Palavras-chave

glycylcycline, tigecycline, analytical methods, broad-spectrum antibiotic

Como citar

Therapeutic Drug Monitoring. Philadelphia: Lippincott Williams & Wilkins, v. 32, n. 3, p. 282-288, 2010.