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dc.contributor.authorKitagawa, Rodrigo Rezende
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorCarlos, Iracilda Zeppone [UNESP]
dc.contributor.authorRaddi, Maria Stella Gonçalves [UNESP]
dc.date.accessioned2014-05-20T13:25:13Z
dc.date.available2014-05-20T13:25:13Z
dc.date.issued2011-12-01
dc.identifierhttp://dx.doi.org/10.1590/S0102-695X2011005000136
dc.identifier.citationRevista Brasileira de Farmacognosia. Sociedade Brasileira de Farmacognosia, v. 21, n. 6, p. 1084-1088, 2011.
dc.identifier.issn0102-695X
dc.identifier.urihttp://hdl.handle.net/11449/7977
dc.description.abstractLarge number of quinones has been associated with antitumor, antibacterial, antimalarial and antifungal activities. In this work we describe the effect of the naphthoquinone, 5-methoxy-3,4-dehydroxanthomegnin, on murine tumor cells (LP07 and LM2) and its immunomodulatory effect on nitric oxide (NO) production on LPS-stimulated macrophages. The results have shown that 5-methoxy-3,4-dehydroxanthomegnin was a significant inhibitor of LPS-stimulated NO generation from macrophage (inhibition percentage ranged from 97.4 to 98.9%) and a strong cytotoxic agent against both tumor cells LP07 and LM2 (CI50 6.2±0.36 µM and 74.6±1.9 µM, respectively). These results indicate that the 5-methoxy-3,4-dehydroxanthomegnin may show promising activity in the treatment of murine breast and lung cancer by immunomodulatory and antiproliferative activities.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent1084-1088
dc.language.isoeng
dc.publisherSociedade Brasileira de Farmacognosia
dc.relation.ispartofRevista Brasileira de Farmacognosia
dc.sourceSciELO
dc.subject5-methoxy-3,4-dehydroxanthomegninen
dc.subjectcytotoxic activityen
dc.subjectimmunomodulatoryen
dc.subjectnaphthoquinoneen
dc.titleAntitumor and immunomodulatory effects of the naphthoquinone 5-methoxy-3,4-dehydroxanthomegninen
dc.typeArtigo
dc.contributor.institutionUniversidade Federal do Espírito Santo (UFES)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationUniversidade Federal do Espírito Santo (UFES) Departamento de Ciências Farmacêuticas
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho Instituto de Química de Araraquara
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho Faculdade de Ciências Farmacêuticas de Araraquara
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho Instituto de Química de Araraquara
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho Faculdade de Ciências Farmacêuticas de Araraquara
dc.identifier.doi10.1590/S0102-695X2011005000136
dc.identifier.scieloS0102-695X2011000600019
dc.identifier.wosWOS:000297216900019
dc.rights.accessRightsAcesso aberto
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, São Vicentept
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
dc.identifier.fileS0102-695X2011000600019.pdf
dc.identifier.lattes7927877224326837
dc.identifier.orcid0000-0003-3032-2556
unesp.author.lattes7927877224326837
unesp.author.orcid0000-0002-0084-3468[3]
unesp.author.orcid0000-0003-3032-2556[2]
dc.relation.ispartofjcr1.596
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