Now showing items 1-3 of 3
Stereoselective analysis of carvedilol in human plasma and urine using HPLC after chiral derivatization
(Biopharmaceutics & Drug Disposition, 2008-07-01) [Artigo]
An enantioselective high-performance liquid chromatographic method for the analysis of carvedilol in plasma and urine was developed and validated using (-)-menthyl chloroformate (MCF) as a derivatizing reagent. Chloroform ...
The effect of pyrazinamide and rifampicin on isoniazid metabolism in rats
(Biopharmaceutics & Drug Disposition, 2007-09-01) [Artigo]
Hepatotoxicity is the main concern during tuberculosis chemotherapy with the first-line drugs isoniazid (INH), rifampicin (RMP) and pyrazinamide (PYR). Since these hepatotoxic events have been associated with INH metabolites, ...
The effect of pH on horseradish peroxidase-catalyzed oxidation of melatonin: Production of N1-acetyl-N2-formyl-5- methoxykynuramine versus radical-mediated degradation
(Journal of Pineal Research, 2007-04-01) [Artigo]
There is a growing body of evidence that melatonin and its oxidation product, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK), have anti-inflammatory properties. From a nutritional point of view, the discovery of melatonin ...