Now showing items 1-10 of 304
Folk uses and pharmacological properties of Casearia sylvestris: a medicinal review
(Anais da Academia Brasileira de Ciências, 2011-12-01) [Artigo]
Usos populares e pesquisas científicas têm destacado a importância dos extratos da planta Casearia sylvestris e seu grande potencial bioativo. Neste trabalho, objetiva-se revisar as propriedades farmacológicas de C. ...
Tonic modulation of anxiety-like behavior by corticotropin-releasing factor (CRF) type 1 receptor (CRF1) within the medial prefrontal cortex (mPFC) in male mice: Role of protein kinase A (PKA)
(Hormones And Behavior, 2014-07-01) [Artigo]
The medial prefrontal cortex (mPFC) and the neuropeptide corticotropin-releasing factor (CRF) have recently been receiving more attention from those interested in the neurobiology of anxiety. Here, we investigated the CRF ...
Caracterização anatômica e fitoquímica de folhas e rizomas de Hedychium coronarium J. König (Zingiberaceae)
(Revista Brasileira de Plantas Medicinais, 2010-06-01) [Artigo]
Devido a grande potencialidade na utilização de Hedychium coronarium, na medicina popular e também como biorremediadora no tratamento de efluentes, objetivou-se uma diagnose dos órgãos, folha e rizoma, para elucidar ...
Evaluation of antidiarrhoeal effects of Psidium guajava L. (Myrtaceae) aqueous leaf extract in mice
(Revista de Ciências Farmacêuticas Básica e Aplicada, 2006-12-01) [Artigo]
A crude aqueous extract of the leaves of the guava tree, Psidium guajava L. (Myrtaceae), were studied for antidiarrhoeal effects, to place one of its traditional medical uses. The extract induced a decrease in the propulsive ...
Pharmacogenetics-based population pharmacokinetic analysis of gabapentin in patients with chronic pain: Effect of OCT2 and OCTN1 gene polymorphisms
(Basic and Clinical Pharmacology and Toxicology, 2019-03-01) [Artigo]
Gabapentin (GAB) is eliminated unchanged in urine, and organic cation transporters (OCT2 and OCTN1) have been shown to play a role in GAB renal excretion. This prospective clinical study aimed to evaluate the genetic ...
Circadian time-dependent effects of fencamfamine on inhibition of dopamine uptake and release in rat striatal slices
(Brazilian Journal of Medical and Biological Research, 1997-05-01) [Artigo]
Fencamfamine (FCF) is a central stimulant that facilitates central dopaminergic transmission through inhibition of dopamine uptake and enhanced release of the transmitter. We evaluated the changes in the inhibition of ...
Novel nanostructure obtained from pacamã, Lophiosilurus alexandri, skin mucus presents potential as a bioactive carrier in fish
(Aquaculture, 2019-10-15) [Artigo]
Nanoparticles to delivery drugs and immunomodulatory substances in fish have been widely studied by several research groups. In general, these nanoparticles are polymers, ceramic, fullerenes and metal derivates which can ...
Stress induces behavioral sensitization, increases nicotine-seeking behavior and leads to a decrease of CREB in the nucleus accumbens
(Pharmacology Biochemistry and Behavior, 2012-05-01) [Artigo]
Experimental evidence shows that exposure to stress engenders behavioral sensitization and increases drug-seeking and leads to intense drug taking. However the molecular mechanisms involved in these processes is not well ...
Cardiovascular Complications following Chronic Treatment with Cocaine and Testosterone in Adolescent Rats
(Plos One, 2014-08-14) [Artigo]
Concomitant use of anabolic androgenic steroids and cocaine has increased in the last years. However, the effects of chronic exposure to these substances during adolescence on cardiovascular function are unknown. Here, we ...
Histopathological changes in the gill, liver and kidney of pacu (Piaractus mesopotamicus, Holmberg, 1887) exposed to various concentrations of trichlorfon
(Journal of Applied Ichthyology, 2009-02-01) [Artigo]