Now showing items 1-10 of 50
Animal models of alcohol and drug dependence
(Revista Brasileira de Psiquiatria, 2013) [Artigo]
Drug addiction has serious health and social consequences. In the last 50 years, a wide range of techniques have been developed to model specific aspects of drug-taking behaviors and have greatly contributed to the ...
Influence of the dopaminergic system, CREB, and transcription factor-B on cocaine neurotoxicity
(Brazilian Journal of Medical and Biological Research, 2013-11-01) [Artigo]
Cocaine is a widely used drug and its abuse is associated with physical, psychiatric and social problems. Abnormalities in newborns have been demonstrated to be due to the toxic effects of cocaine during fetal development. ...
EFFECT OF FENCAMFAMINE ON AVOIDANCE PERFORMANCES OF RATS
(Brazilian Journal of Medical and Biological Research, 1991-01-01) [Artigo]
The effects of fencamfamine (1.0 and 5.0 mg/kg, ip, single dose) on an inhibitory task were studied in rats (N = 15 per group). Post-training treatment with fencamfamine (1.0 mg/kg) significantly increased avoidance latency ...
Effect of the Single or Combined Administration of Cocaine and Testosterone on Cardiovascular Function and Baroreflex Activity in Unanesthetized Rats
(Journal of Cardiovascular Pharmacology, 2012-03-01) [Artigo]
Abuse of cocaine and androgenic-anabolic steroids has become a serious public health problem. Despite reports of an increase in the incidence of simultaneous illicit use of these substances, potential toxic interactions ...
Influence of the single or combined administration of cocaine and testosterone in autonomic and neuroendocrine responses to acute restraint stress
(Journal of Psychopharmacology, 2012-10-01) [Artigo]
Abuse of cocaine and androgenic-anabolic steroids (AASs) has become a serious public health problem. Despite reports of an increase in the incidence of simultaneous abuse of these substances, potential toxic interactions ...
Involvement of dopamine receptors in diethylpropion-induced conditioning place preference
(Brazilian Journal of Medical and Biological Research, 1998-04-01) [Artigo]
Diethylpropion (DEP) is an amphetamine-like agent used as an anorectic drug. Abuse of DEP has been reported and some restrictions of its use have been recently imposed. The conditioning place preference (CPP) paradigm was ...
Context-specific modulation of cocaine-induced locomotor sensitization and ERK and CREB phosphorylation in the rat nucleus accumbens
(European Journal of Neuroscience, 2009-11-01) [Artigo]
Learned associations are hypothesized to develop between drug effects and contextual stimuli during repeated drug administration to produce context-specific sensitization that is expressed only in the drug-associated ...
Matemal separation affects cocaine-induced locomotion and response to novelty in adolescent, but not in adult rats
(Brain Research, 2004-07-02) [Artigo]
Maternal separation is known to exert long-term effects on both behavior and the neuroendocrine system. We investigated cocaine-induced locomotor activation as well as the locomotor and corticosterone response to forced ...
Stress Abolishes the Effect of Previous Chronic Ethanol Consumption on Drug Place Preference and on the Mesocorticolimbic Brain Pathway
(Alcoholism: Clinical and Experimental Research, 2014-05-01) [Artigo]
BackgroundConditioned place preference (CPP) to ethanol (EtOH) is an important addiction-related alteration thought to be mediated by changed neurotransmission in the mesocorticolimbic brain pathway. Stress is a factor of ...
Trypanocidal activity of fruits extracts of Solanum lycocarpum St. Hill. on Trypanosoma cruzi and Trypanosoma brucei strains
(Planta Medica, 2012-08-01) [Resumo]