Now showing items 1-10 of 188
Folk uses and pharmacological properties of Casearia sylvestris: a medicinal review
(Anais da Academia Brasileira de Ciências, 2011-12-01) [Artigo]
Usos populares e pesquisas científicas têm destacado a importância dos extratos da planta Casearia sylvestris e seu grande potencial bioativo. Neste trabalho, objetiva-se revisar as propriedades farmacológicas de C. ...
Tonic modulation of anxiety-like behavior by corticotropin-releasing factor (CRF) type 1 receptor (CRF1) within the medial prefrontal cortex (mPFC) in male mice: Role of protein kinase A (PKA)
(Hormones And Behavior, 2014-07-01) [Artigo]
The medial prefrontal cortex (mPFC) and the neuropeptide corticotropin-releasing factor (CRF) have recently been receiving more attention from those interested in the neurobiology of anxiety. Here, we investigated the CRF ...
Evaluation of antidiarrhoeal effects of Psidium guajava L. (Myrtaceae) aqueous leaf extract in mice
(Revista de Ciências Farmacêuticas Básica e Aplicada, 2006-12-01) [Artigo]
A crude aqueous extract of the leaves of the guava tree, Psidium guajava L. (Myrtaceae), were studied for antidiarrhoeal effects, to place one of its traditional medical uses. The extract induced a decrease in the propulsive ...
Circadian time-dependent effects of fencamfamine on inhibition of dopamine uptake and release in rat striatal slices
(Brazilian Journal of Medical and Biological Research, 1997-05-01) [Artigo]
Fencamfamine (FCF) is a central stimulant that facilitates central dopaminergic transmission through inhibition of dopamine uptake and enhanced release of the transmitter. We evaluated the changes in the inhibition of ...
Stress induces behavioral sensitization, increases nicotine-seeking behavior and leads to a decrease of CREB in the nucleus accumbens
(Pharmacology Biochemistry and Behavior, 2012-05-01) [Artigo]
Experimental evidence shows that exposure to stress engenders behavioral sensitization and increases drug-seeking and leads to intense drug taking. However the molecular mechanisms involved in these processes is not well ...
Cardiovascular Complications following Chronic Treatment with Cocaine and Testosterone in Adolescent Rats
(Plos One, 2014-08-14) [Artigo]
Concomitant use of anabolic androgenic steroids and cocaine has increased in the last years. However, the effects of chronic exposure to these substances during adolescence on cardiovascular function are unknown. Here, we ...
Histopathological changes in the gill, liver and kidney of pacu (Piaractus mesopotamicus, Holmberg, 1887) exposed to various concentrations of trichlorfon
(Journal of Applied Ichthyology, 2009-02-01) [Artigo]
Assessment of the chemopreventive effect of casearin B, a clerodane diterpene extracted from Casearia sylvestris (Salicaceae)
(Food and Chemical Toxicology, 2013-03-01) [Artigo]
Studies have shown that Casearia sylvestris compounds protect DNA from damage both in vitro and in vivo. Complementarily, the aim of the present study was to assess the chemopreventive effect of casearin B (CASB) against ...
Effect of nωnla, an inhibitor of No-synthase, on the release of tissue-plasminogem activator from rat aorta
(Revista de Ciencias Farmaceuticas, 2003-12-01) [Artigo]
Alterations in the synthesis or enhanced inactivation of nitric oxide (NO) and increase in fibrin deposition in the vascular bed lead to an imbalance that can induced intravascular coagulation. NO is produced through ...
Animal models of alcohol and drug dependence
(Revista Brasileira de Psiquiatria, 2013) [Artigo]
Drug addiction has serious health and social consequences. In the last 50 years, a wide range of techniques have been developed to model specific aspects of drug-taking behaviors and have greatly contributed to the ...