Now showing items 1-5 of 5
Role of TRPV1 channels of the dorsal periaqueductal gray in the modulation of nociception and open elevated plus maze-induced antinociception in mice
(Behavioural Brain Research, 2015) [Artigo]
Recent findings have identified the presence of transient receptor potential vanilloid-1 (TRPV1) channels within the dorsal portion of the periaqueductal gray (dPAG), suggesting their involvement in the control of pain and ...
Stress vulnerability during adolescence: comparison of chronic stressors in adolescent and adult rats
(Psychosomatic Medicine, 2015-02-01) [Artigo]
Objective This study investigated the physiological and somatic changes evoked by daily exposure to the same type of stressor (homotypic) or different aversive stressor stimuli (heterotypic) in adolescent and adult rats, ...
CRF1 and CRF2 receptors in the bed nucleus of the stria terminalis modulate the cardiovascular responses to acute restraint stress in rats
(Pharmacological Research, 2015) [Artigo]
The corticotropin-releasing factor (CRF) is involved in behavioral and physiological responses to emotional stress throughits actioninseverallimbic structures,including the bednucleus ofthe stria terminalis (BNST). ...
Rapid and sensitive ultra-high-pressure liquid chromatography method for quantification of antichagasic benznidazole in plasma: application in a preclinical pharmacokinetic study
(Biomedical Chromatography, 2015-07-01) [Artigo]
Benznidazole (BNZ) and nifurtimox are the only drugs available for treating Chagas disease. In this work, we validated a bioanalytical method for the quantification of BNZ in plasma aimed at improving sensitivity and time ...
Curcumin pharmacokinetic and pharmacodynamic evidences in streptozotocin-diabetic rats support the antidiabetic activity to be via metabolite(s)
(Evidence-based Complementary And Alternative Medicine, 2015-01-01) [Artigo]
This study measures the curcumin concentration in rat plasma by liquid chromatography and investigates the changes in the glucose tolerance and insulin sensitivity of streptozotocin-diabetic rats treated with curcumin-enriched ...