Now showing items 1-10 of 10
5-HT2 receptor activation in the midbrain periaqueductal grey (PAG) reduces anxiety-like behaviour in mice
(Behavioural Brain Research, 2008-02-11) [Artigo]
It is widely acknowledged that the indoleamine neurotransmitter serotonin (5-HT) plays a dual role in the regulation of anxiety, a role that in part depends upon neuroanatomical locus of action. Thus, whereas stimulation ...
Triterpenes and antitubercular activity of Byrsonima crassa
(Química Nova, 2008-01-01) [Artigo]
We evaluated the potential antitubercular activity of triterpenes obtained from leaves and bark of Byrsonima crassa. From chloroform extracts of the leaves, by bioassay-guided fractionation, we obtained mixtures of known ...
Maternal separation stress in male mice: long-term increases in alcohol intake
(Psychopharmacology, 2008-12-01) [Artigo]
In rodents, prolonged maternal separation has been used as a model of developmentally early environmental stress to influence adult drug intake.The aim of the present study was to evaluate the long-term effects of prolonged ...
Stereoselective analysis of carvedilol in human plasma and urine using HPLC after chiral derivatization
(Biopharmaceutics & Drug Disposition, 2008-07-01) [Artigo]
An enantioselective high-performance liquid chromatographic method for the analysis of carvedilol in plasma and urine was developed and validated using (-)-menthyl chloroformate (MCF) as a derivatizing reagent. Chloroform ...
Effects of chronic stress on nicotine-induced locomotor activity and corticosterone release in adult and adolescent rats
(Addiction Biology, 2008-03-01) [Artigo]
We examined nicotine-induced locomotion and increase in corticosterone plasma levels in adolescent and adult animals exposed to chronic restraint stress. Adolescent [postnatal day (P) 28-37] and adult (P60-67) rats were ...
Reduction of enantioselectivity in the kinetic disposition and metabolism of verapamil in rats exposed to toluene
(Canadian Journal of Physiology and Pharmacology, 2008-05-01) [Artigo]
Toluene and verapamil are subject to extensive oxidative metabolism mediated by CYP enzymes, and their interaction can be stereoselective. In the present study we investigated the influence of toluene inhalation on the ...
The reinstatement of amphetamine-induced place preference is long-lasting and related to decreased expression of AMPA receptors in the nucleus accumbens
(Neuroscience, 2008-01-24) [Artigo]
A great deal of effort has been devoted to elucidating the psychopharmacology underlying addiction and relapse. Long-term neuroadaptations in glutamate transmission seem to be of great relevance for relapse to stimulant ...
Anxiogenic-like effects induced by NMDA receptor activation are prevented by inhibition of neuronal nitric oxide synthase in the periaqueductal gray in mice
(Brain Research, 2008-11-13) [Artigo]
Glutamate-NMDA (N-methyl-D-aspartate) receptor activation within the periaqueductal gray (PAG) leads to antinociceptive, autonomic and behavioral responses characterized as the fear reaction. We have recently demonstrated ...
Maternal separation stress: Long-term increases in alcohol intake in two different behavioral procedures
(Alcoholism: Clinical and Experimental Research, 2008-06-01) [Resumo]
Effects of calcium gluconate and PMSF in the treatment of acute intoxication of chicken by TOCP
(Human & Experimental Toxicology, 2008-03-01) [Artigo]
To examine the efficacy of calcium gluconate (two doses of Ca-Glu 5 mg/kg i.v.) to alleviate the injurious effects of organophosphorus induced delayed neuropathy (OPIDN) in the presence or absence of phenylmethanesulfonyl ...