Now showing items 1-6 of 6
Exposure to acute restraint stress reinstates nicotine-induced place preference in rats
(Behavioural Pharmacology, 2009-02-01) [Artigo]
Tobacco addiction is associated with high rates of relapse to drug use even after prolonged periods of abstinence. Relapse can occur upon reexposure to the drug of abuse, exposure to stress or to stimuli associated with ...
Cocaine induces cell death and activates the transcription nuclear factor kappa-b in pc12 cells
(Molecular Brain, 2009-01-01) [Artigo]
Cocaine is a worldwide used drug and its abuse is associated with physical, psychiatric and social problems. The mechanism by which cocaine causes neurological damage is very complex and involves several neurotransmitter ...
Amphetamine- and nicotine-induced cross-sensitization in adolescent rats persists until adulthood
(Addiction Biology, 2009-07-01) [Artigo]
Nicotine and psychostimulants are often abused in combination and drug abuse often begins during adolescence and can have long-term consequences. Behavioral sensitization has been suggested as an animal model of neuroplasticity ...
Fos-like immunoreactivity in central nervous system of mice simultaneously exposed to the elevated plus-maze and nociception
(Revista Brasileira de Ciências Farmacêuticas, 2005-09-01) [Artigo]
Recentes evidências têm mostrado que a exposição de camundongos ao labirinto em cruz elevado (LCE), um modelo animal de ansiedade, resulta na exibição de analgesia. Com o objetivo de investigar quais as estruturas que são ...
Exposição repetida à cafeína aumenta a atividade locomotora induzida pelo femproporex em ratos adolescentes e adultos
(Revista Brasileira de Ciências Farmacêuticas, 2008-09-01) [Artigo]
A cafeína e o femproporex são substâncias psicoestimulantes. O femproporex é muito utilizado no Brasil como anorexígeno enquanto a cafeína é amplamente consumida como constituinte regular da dieta. A administração repetida ...
Context-specific modulation of cocaine-induced locomotor sensitization and ERK and CREB phosphorylation in the rat nucleus accumbens
(European Journal of Neuroscience, 2009-11-01) [Artigo]
Learned associations are hypothesized to develop between drug effects and contextual stimuli during repeated drug administration to produce context-specific sensitization that is expressed only in the drug-associated ...