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Influence of gasoline inhalation on the enantioselective pharmacokinetics of fluoxetine in rats
(Chirality, 2013-03-01) [Artigo]
Fluoxetine is used clinically as a racemic mixture of (+)-(S) and (-)-(R) enantiomers for the treatment of depression. CYP2D6 catalyzes the metabolism of both fluoxetine enantiomers. We aimed to evaluate whether exposure ...