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Acute, subchronic and chronic 2,4-dichlorophenoxyacetic acid (2,4-D) intoxication in rats
(Veterinary and Human Toxicology, 1996-10-01) [Artigo]
The acute, subchronic and chronic toxicities of 2,4- dichlorophenoxyacetic acid (2,4-D) were studied in rats. Animals were exposed acutely (600 mg/kg), subchronically (200 ppm for 30 d) and chronically (200 ppm for 180 d) ...
Liberação de óxido nítrico e tnf-α em macrófagos peritoneais na presença de Melampodium divaricatum (Asteraceae)
(Revista de Ciencias Farmaceuticas, 2001-12-01) [Artigo]
The immune responses are mediated by a variety cells and molecules that cells secreted. Macrophages are the first cells that participate in the immune response, and, when are activated, release more than hundred compounds ...
Simultaneous analysis of the enantiomers of verapamil and norverapamil in rat plasma by liquid chromatography tandem mass spectrometry
(Journal of Pharmaceutical and Biomedical Analysis, 2007-12-21) [Artigo]
An enantioselective micromethod for the simultaneous analysis of verapamil (VER) and norverapamil (NOR) in plasma was developed, validated and applied to the study of the kinetic disposition of VER and NOR after the ...
Nasal administration of liquid crystal precursor mucoadhesive vehicle as an alternative antiretroviral therapy
(European Journal of Pharmaceutics and Biopharmaceutics, 2013-05-01) [Artigo]
The purpose of this study was to develop a mucoadhesive stimuli-sensitive drug delivery system for nasal administration of zidovudine (AZT). The system was prepared by formulating a low viscosity precursor of a liquid ...
Synthesis and characterization of nanostructured lipid nanocarriers for enhanced sun protection factor of octyl p-methoxycinnamate
(AAPS PharmSciTech, 2020-01-01) [Artigo]
Sunlight is important to health, but higher exposure to radiation causes early aging of the skin and skin damage that can lead to skin cancers. This study aimed at producing a stable octyl p-methoxycinnamate (OMC)–loaded ...
DAILY VARIATION IN PLASMA-CONCENTRATION OF FENCAMFAMINE AND STRIATAL DOPAMINE-RECEPTORS IN RATS
(Brazilian Journal of Medical and Biological Research, 1994-03-01) [Artigo]
Fencamfamine (FCF) is a psychostimulant drug classified as an indirect dopamine agonist. In the present study we evaluated the daily variation in plasma FCF concentration and in striatal dopamine receptors. Adult male ...
Noradrenergic neurotransmission within the bed nucleus of the stria terminalis modulates the retention of immobility in the rat forced swimming test
(Behavioural Pharmacology, 2013-06-01) [Artigo]
The bed nucleus of the stria terminalis (BNST) is a limbic structure that has a direct influence on the autonomic, neuroendocrine, and behavioral responses to stress. It was recently reported that reversible inactivation ...
Analysis of ibuprofen enantiomers in rat plasma by liquid chromatography with tandem mass spectrometry
(Journal of Separation Science, 2014-04-01) [Artigo]
A sensitive and selective method for the analysis of ibuprofen enantiomers by LC-MS/MS was developed and validated for the purpose of application in pharmacokinetic studies in small experimental animals. Aliquots of 200 L ...
Mechanisms in the bed nucleus of the stria terminalis involved in control of autonomic and neuroendocrine functions: A review
(Current Neuropharmacology, 2013-04-30) [Resenha]
The bed nucleus of the stria terminalis (BNST) is a heterogeneous and complex limbic forebrain structure, which plays an important role in controlling autonomic, neuroendocrine and behavioral responses. The BNST is thought ...
Chronic Fluoxetine Impairs the Effects of 5-HT1A and 5-HT2C Receptors Activation in the PAG and Amygdala on Antinociception Induced by Aversive Situation in Mice
(Frontiers in Pharmacology, 2020-03-11) [Artigo]
Growing evidence suggests an important role of fluoxetine with serotonin 5-HT1A and 5-HT2C receptors in the modulation of emotion and nociception in brain areas such as the amygdala and periaqueductal gray (PAG). Acute ...