Now showing items 1-10 of 22
Phylogenetic and antimicrobial resistance gene analysis of Salmonella Typhimurium strains isolated in Brazil by whole genome sequencing
(PLoS ONE, 2018-08-01) [Artigo]
Whole genome sequencing (WGS) has been used as a powerful technology for molecular epidemiology, surveillance, identification of species and serotype, identification of the sources of outbreaks, among other purposes. In ...
Cytotoxicity of doxorubicin-loaded PLGA and PLGA-PEI nanoparticles: relevance for anti-tumor effects and cardiotoxicity
(European Journal Of Clinical Investigation, 2018-06-01) [Resumo]
Amygdaloid involvement in the defensive behavior of mice exposed to the open elevated plus-maze
(Behavioural Brain Research, 2018-02-15) [Artigo]
Previous studies have shown that the exposure to an open elevated plus maze (oEPM, an EPM with all four open arms) elicits fear/anxiety-related responses in laboratory rodents. However, very little is known about the ...
Annexin A12-26 treatment improves skin heterologous transplantation by modulating inflammation and angiogenesis processes
(Frontiers in Pharmacology, 2018-09-10) [Artigo]
Skin graft successful depends on reduction of local inflammation evoked by the surgical lesion and efficient neovascularization to nutrition the graft. It has been shown that N-terminal portion of the Annexin A1 protein ...
The role of organic cation transporter 2 inhibitor cimetidine, experimental diabetes mellitus and metformin on gabapentin pharmacokinetics in rats
(Life Sciences, 2018-05-01) [Artigo]
Purpose: We investigated the influence of diabetes mellitus (DM), glycemic control with insulin, cimetidine (Oct2 inhibitor) and metformin (Oct2 substrate) on the kinetic disposition of GAB in rats. Main methods: Male ...
Plasma and peritoneal fluid concentrations of ceftriaxone after intravenous and intraperitoneal administration in horses
(Veterinary Journal, 2018-04-01) [Artigo]
Intraperitoneal (IP) use of antimicrobial agents may lead to therapeutic effects with better clinical results than intravenous (IV) administration. The aim of this study was to compare plasma and peritoneal fluid concentrations ...
Green coffee seed residue: A sustainable source of antioxidant compounds
(Food Chemistry, 2018-04-25) [Artigo]
Oil extraction from green coffee seeds generates residual mass that is discarded by agribusiness and has not been previously studied. Bioactive secondary metabolites in coffee include antioxidant phenolic compounds, such ...
Application of aqueous two-phase micellar system to improve extraction of adenoviral particles from cell lysate
(Biotechnology And Applied Biochemistry, 2018-05-01) [Artigo]
Viral vectors are important in medical approaches, such as disease prevention and gene therapy, and their production depends on efficient prepurification steps. In the present study, an aqueous two-phase micellar system ...
Alzheimer's disease: A review from the pathophysiology to diagnosis, new perspectives for pharmacological treatment
(Current Medicinal Chemistry, 2018-01-01) [Resenha]
Dementia is characterized by the impairment of cognition and behavior of people over 65 years. Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder in the world, as approximately 47 million people are ...
Interplay between 5-HT2C and 5-HT1A receptors in the dorsal periaqueductal gray in the modulation of fear-induced antinociception in mice
(Neuropharmacology, 2018-09-15) [Artigo]
The confinement of rodents to the open arm of the elevated-plus maze provokes antinociception (OAA). As a type of defensive reaction, the OAA has been investigated through systemic and intramesencephalic (e.g., dorsal ...