Now showing items 11-16 of 16
Pharmacokinetic properties, in vitro metabolism and plasma protein binding of govaniadine an alkaloid isolated from Corydalis govaniana Wall
(Journal Of Pharmaceutical And Biomedical Analysis, 2016-11-30) [Artigo]
Govaniadine (GOV) is an alkaloid isolated from Corydalis govaniana Wall. It has been reported to show a different number of biological activities including anti-urease, leishmanicidal and antinociceptive. The present study ...
Physicochemical characterization by AFM, FT-IR and DSC and biological assays of a promising antileishmania delivery system loaded with a natural Brazilian product
(Journal of Pharmaceutical and Biomedical Analysis, 2016-05-10) [Artigo]
The control and treatment of Leishmaniasis, a neglected and infectious disease affecting approximately 12 million people worldwide, are challenging. Leishmania parasites multiply intracellularly within macrophages located ...
Recombinant L-asparaginase 1 from Saccharomyces cerevisiae: An allosteric enzyme with antineoplastic activity
(Scientific Reports, 2016-11-08) [Artigo]
L-asparaginase (L-ASNase) (EC 18.104.22.168) is an important enzyme for the treatment of acute lymphoblastic leukaemia. Currently, the enzyme is obtained from bacteria, Escherichia coli and Erwinia chrysanthemi. The bacterial ...
UHPLC quantitation method for new thiazolidinedione LPSF/GQ-02 and in vitro/in vivo kinetic studies
(Drug Metabolism Letters, 2016-09-01) [Artigo]
Background: LPSF/GQ-02 is a promising benzylidene thiazolidinedione that has demonstrated antidiabetic,antidyslipidemic,anti-atherosclerotic properties and can also treat non-alcoholic fatty liver disease. Despite all ...
Immunological correlates of favorable long-term clinical outcome in multiple sclerosis patients after autologous hematopoietic stem cell transplantation
(Clinical Immunology, 2016-08-01) [Artigo]
High dose immunosuppression followed by autologous hematopoietic stem cell transplantation (AHSCT) induces prolonged clinical remission in multiple sclerosis (MS) patients. However, how patient immune profiles are associated ...
Polymorphisms in B cell co-stimulatory genes are associated with IgG antibody responses against blood-stage proteins of plasmodium vivax
(PLoS ONE, 2016-02-01) [Artigo]
The development of an effective immune response can help decrease mortality from malaria and its clinical symptoms. However, this mechanism is complex and has significant inter-individual variation, most likely owing to ...