Now showing items 241-250 of 250
A kinetic study of the main guaco metabolites using syrup formulation and the identification of an alternative route of coumarin metabolism in humans
(Plos One, 2015-03-10) [Artigo]
For decades guaco species have been empirically used for the treatment of respiratory diseases. However, studies have shown that the toxic and therapeutic effects of the main guaco metabolites are dose-dependent, and none ...
Chemical Composition and Trypanocidal Activity of the Essential Oils from Hedychium coronarium J. Koenig (Zingiberaceae)
(ISRN Infectious Diseases, 2013) [Artigo]
The composition of the essential oils (EO) from leaves and rhizomes of Hedychium coronarium was analyzed both by gas chromatography and gas chromatography-mass spectroscopy. Thirty and thirty-nine compounds were identified, ...
Natural rubber latex: Study of a novel carrier for Casearia sylvestris swartz delivery
(ISRN Polymer Science, 2014) [Artigo]
Natural rubber latex (NRL) from Hevea brasiliensis has showed interesting biomedical properties as improving wound healing, cell adherence, tissue formation, and angiogenesis. It is used for biosynthesis of nanoparticles, ...
Testes preliminares de motilidade intestinal e toxicidade oral aguda com extrato de cascas pulverizadas de Endopleura uchi (Huber) Cuatrec: (Humiriaceae) em camundongos
(Revista Pan-Amazônica de Saúde, 2010) [Artigo]
The aim of this work was to analyze the acute oral toxicity and the effects on intestinal motility of the extract obtained through decoction 20% (m/v) of Endopleura uchi, popularly known as "uxi-amarelo", a native plant ...
Immediate and long-term effects of psychological stress during adolescence in cardiovascular function: comparison of homotypic vs heterotypic stress regimens
(International Journal of Developmental Neuroscience, 2015) [Artigo]
Adolescence has been proposed as an ontogenic period of vulnerability to stress. Nevertheless, the impact of stressful events during adolescence in cardiovascular activity is poorly understood. Therefore, the purpose of ...
CRF1 and CRF2 receptors in the bed nucleus of the stria terminalis modulate the cardiovascular responses to acute restraint stress in rats
(Pharmacological Research, 2015) [Artigo]
The corticotropin-releasing factor (CRF) is involved in behavioral and physiological responses to emotional stress throughits actioninseverallimbic structures,including the bednucleus ofthe stria terminalis (BNST). ...
Cardiovascular and autonomic alterations in rats with parkinsonism induced by 6-OHDA and treated with L-DOPA
(Life Sciences, 2015) [Artigo]
Evaluate the effects caused by L-DOPA on cardiovascular and autonomic parameters in an animal model of Parkinsonism induced by 6-hydroxydopamine (6-OHDA).Adult male Wistar rats were subjected to bilateral microinfusion of ...
Evaluation of acute dermal toxicity of components of nanostructured systems
(Toxicology Letters, 2010-07-17) [Resumo]
Biocompatible microemulsion modifies the pharmacokinetic profile and cardiotoxicity of doxorubicin
(Journal of Pharmaceutical Sciences, 2013-01-01) [Artigo]
Doxorubicin (DOX) is an anthracycline antibiotic with a broad antitumor spectrum. However, the clinical use of DOX is limited because of its cardiotoxicity, a dose-dependent effect. Colloidal drug delivery systems, such ...
Nasal administration of liquid crystal precursor mucoadhesive vehicle as an alternative antiretroviral therapy
(European Journal of Pharmaceutics and Biopharmaceutics, 2013-05-01) [Artigo]
The purpose of this study was to develop a mucoadhesive stimuli-sensitive drug delivery system for nasal administration of zidovudine (AZT). The system was prepared by formulating a low viscosity precursor of a liquid ...