Now showing items 21-30 of 250
Leishmanicidal Activities of Novel Synthetic Furoxan and Benzofuroxan Derivatives
(Antimicrobial Agents and Chemotherapy, 2014-08-01) [Artigo]
A novel series of furoxan (1,2,5-oxadiazole 2-oxide) (compounds 3, 4a and -b, 13a and -b, and 14a to -f) and benzofuroxan (benzo[c][1,2,5] oxadiazole 1-oxide) (compounds 7 and 8a to -c) derivatives were synthesized, ...
Cannabidiol administration into the bed nucleus of the stria terminalis alters cardiovascular responses induced by acute restraint stress through 5-HT1A receptor
(European Neuropsychopharmacology, 2013-09-01) [Artigo]
Systemic administration of cannabidiol (CBD) is able to attenuate cardiovascular responses to acute restraint stress through activation of 5-HT1A receptors. Previous results from our group suggest that the bed nucleus of ...
Envolvimento do sistema dopaminérgico na sensibilização comportamental ao femproporex
(Revista de Ciencias Farmaceuticas, 2002-12-01) [Artigo]
The effects of repeated administration of fenproporex (FEN) on motor activity of rats were studied. FEN-treated group (5.0 mg/kg, i.p., single dose, 7 consecutive days), showed a marked increase in the motor activity of ...
Determination of calcium by atomic absorption spectrophotometry applied to the preparation of alginate:chitosan complexes
(Revista de Ciencias Farmaceuticas, 2004-12-01) [Artigo]
Polysaccharicles, as alginate and chitosan, have been used to obtain modified release dosage forms. Alginate, due to its property of building gels during the complex formation with calcium ions, allows the building of ...
Effect of NωNLA or dexamethasone on vascular hyporeactivity induced by E. coli endotoxin in sham and adrenalectomized rats
(Revista de Ciencias Farmaceuticas, 2000-12-01) [Artigo]
Induction of iNOS by bacterial products is considered to be part of the defense mechanism against infection. However, it has been suggested that the bacterial-induced NO-overproduction may be involved in the vascular ...
ESTUDO COMPARATIVO DA ATIVIDADE FIBRINOLITICA DO PLASMA DE RATO EM FIBRINA HUMANA, BOVINA E MURINA
(Revista de Ciencias Farmaceuticas, 1992-12-01) [Artigo]
Analysis of rocuronium in human plasma by liquid chromatography-tandem mass spectrometry with application in clinical pharmacokinetics
(Journal of Pharmaceutical and Biomedical Analysis, 2014-03-05) [Artigo]
Rocuronium (ROC) is a neuromuscular blocking agent used in surgical procedures which is eliminated primarily by biliary excretion. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated ...
Acute, subchronic and chronic 2,4-dichlorophenoxyacetic acid (2,4-D) intoxication in rats
(Veterinary and Human Toxicology, 1996-10-01) [Artigo]
The acute, subchronic and chronic toxicities of 2,4- dichlorophenoxyacetic acid (2,4-D) were studied in rats. Animals were exposed acutely (600 mg/kg), subchronically (200 ppm for 30 d) and chronically (200 ppm for 180 d) ...
Involvement of the insular cortex in the consolidation and expression of contextual fear conditioning
(European Journal of Neuroscience, 2013-07-01) [Artigo]
The insular cortex (IC) has been reported to be involved in the modulation of memory and autonomic and defensive responses. However, there is conflicting evidence about the role of the IC in fear conditioning. To explore ...
Influence of the dopaminergic system, CREB, and transcription factor-B on cocaine neurotoxicity
(Brazilian Journal of Medical and Biological Research, 2013-11-01) [Artigo]
Cocaine is a widely used drug and its abuse is associated with physical, psychiatric and social problems. Abnormalities in newborns have been demonstrated to be due to the toxic effects of cocaine during fetal development. ...