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UHPLC Quantitation Method and In vitro Studies of Two New Phthalimide Derivatives Planned to Treat Sickle Cell Disease
(Current Pharmaceutical Analysis, 2017-01-01) [Artigo]
Background: Sickle cell disease is characterized by the occurrence of acute disability and progressive organ damage, and it is one of the most common and severe monogenic disorders around the world. Since hydroxycarbamide ...
Pharmacokinetics of hydroxymethylnitrofurazone and its parent drug nitrofurazone in rabbits
(Drug Metabolism Letters, 2013) [Artigo]
The prodrug hydroximethylnitrofurazone (NFOH) presents antichagasic activity with greatly reduced toxicity compared to its drug matrix nitrofurazone (NF). Besides these new characteristics, the prodrug was more active ...
Leishmanicidal activity of different parts from Arrabidaea brachypoda (DC.) Bureau (Bignoniaceae)
(Revista da Universidade Vale do Rio Verde, 2012) [Artigo]
Infections by protozoans of the genus Leishmania are the major worldwide health problem, with high endemicity in developing countries. The drugs of choice for the treatment of leishmaniasis are the pentavalent antimonials, ...
Probiotic soy product supplemented with isoflavones improves the lipid profile of moderately hypercholesterolemic men: A randomized controlled trial
(Nutrients, 2016-01-19) [Artigo]
Background: Cardiovascular disease is the leading cause of worldwide morbidity and mortality. Several studies have demonstrated that specific probiotics affect the host’s metabolism and may influence the cardiovascular ...
Infecções parasitárias na gravidez: prevalência e auto medicação com plantas medicinais na região de Araraquara -São Paulo - Brasil
(Raízes e Rumos, 2014) [Artigo]
Pregnant women are individuals own characteristics, metabolic, endocrinological and immunological transient patterns and require special care. To estimate the prevalence of intestinal parasites in pregnant women and use ...
Application of aqueous two-phase micellar system to improve extraction of adenoviral particles from cell lysate
(Biotechnology And Applied Biochemistry, 2018-05-01) [Artigo]
Viral vectors are important in medical approaches, such as disease prevention and gene therapy, and their production depends on efficient prepurification steps. In the present study, an aqueous two-phase micellar system ...
Imprint Desorption Electrospray Ionization Mass Spectrometry Imaging for Monitoring Secondary Metabolites Production during Antagonistic Interaction of Fungi
(Analytical Chemistry, 2015-12-15) [Artigo]
Direct analysis of microbial cocultures grown on agar media by desorption electrospray ionization mass spectrometry (DESI-MS) is quite challenging. Due to the high gas pressure upon impact with the surface, the desorption ...
Concomitant stress potentiates the preference for, and consumption of, ethanol induced by chronic pre-exposure to ethanol
(Brazilian Journal of Medical and Biological Research, 2016-01-01) [Artigo]
Ethanol abuse is linked to several acute and chronic injuries that can lead to health problems. Ethanol addiction is one of the most severe diseases linked to the abuse of this drug. Symptoms of ethanol addiction include ...
Ecotoxicological risk assessment of the Acid Black 210 dye
(Toxicology, 2017-02-01) [Artigo]
The Acid Black 210 dye is one of the most used black dyes by the leather industry. This compound contains three azo groups in its chemical structure, and has been quoted as a non-regulated dye with toxicological concern, ...
Estimativas de custo de produção e rentabilidade de plantas medicinais: carqueja cultivada em Cajuru, Estado de São Paulo
(Informações Econômicas, 2010) [Artigo]
O objetivo deste trabalho foi calcular o custo de produção de carqueja cultivada no município de Cajuru (SP) e analisar seus indicadores de rentabilidade. O cultivo de quatro anos compreendeu no primeiro ano a fase de ...