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Benznidazole Extended-Release tablets for improved treatment of chagas disease: Preclinical pharmacokinetic study
(Antimicrobial Agents and Chemotherapy, 2016-04-01) [Artigo]
Benznidazole (BNZ) is the first-line drug for the treatment of Chagas disease. The drug is available in the form of immediaterelease tablets for 100-mg (adult) and 12.5-mg (pediatric) doses. The drug is administered two ...
UHPLC quantitation method for new thiazolidinedione LPSF/GQ-02 and in vitro/in vivo kinetic studies
(Drug Metabolism Letters, 2016-09-01) [Artigo]
Background: LPSF/GQ-02 is a promising benzylidene thiazolidinedione that has demonstrated antidiabetic,antidyslipidemic,anti-atherosclerotic properties and can also treat non-alcoholic fatty liver disease. Despite all ...