RSS 1.0Artigos - Princípios Ativos Naturais e Toxicologia - FCFAR
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Aerobic training prevents cardiometabolic changes triggered by myocardial infarction in ovariectomized rats
; ; ; ; ; ; ; Crestani, Carlos Cesar
; ; et al. (Journal of Cellular Physiology, 2020) [Artigo]
This study aimed to evaluate the impact of aerobic training (AT) on autonomic, cardiometabolic, ubiquitin-proteasome activity, and inflammatory changes evoked by myocardial infarction (MI) in ovariectomized rats. Female ... -
Synthesis and characterization of nanostructured lipid nanocarriers for enhanced sun protection factor of octyl p-methoxycinnamate
Prado, Alice Haddad Do; Araújo, Victor Hugo Sousa ; ; Fonseca-Santos, Bruno ; ; Peccinini, Rosângela Gonçalves ; Chorilli, Marlus (AAPS PharmSciTech, 2020) [Artigo]
Sunlight is important to health, but higher exposure to radiation causes early aging of the skin and skin damage that can lead to skin cancers. This study aimed at producing a stable octyl p-methoxycinnamate (OMC)–loaded ... -
Chronic Fluoxetine Impairs the Effects of 5-HT1A and 5-HT2C Receptors Activation in the PAG and Amygdala on Antinociception Induced by Aversive Situation in Mice
Baptista-de-Souza, Daniela; Tavares, Lígia Renata Rodrigues ; Furuya-da-Cunha, Elke Mayumi ; Carneiro de Oliveira, Paulo Eduardo ; Canto-de-Souza, Lucas ; Nunes-de-Souza, Ricardo Luiz ; Canto-de-Souza, Azair (Frontiers in Pharmacology, 2020) [Artigo]
Growing evidence suggests an important role of fluoxetine with serotonin 5-HT1A and 5-HT2C receptors in the modulation of emotion and nociception in brain areas such as the amygdala and periaqueductal gray (PAG). Acute ... -
Inhibition of the left medial prefrontal cortex (mPFC) prolongs the social defeat-induced anxiogenesis in mice: Attenuation by NMDA receptor blockade in the right mPFC
Victoriano, Gabriel; Santos-Costa, Nathália ; Mascarenhas, Diego Cardozo ; Nunes-de-Souza, Ricardo Luiz (Behavioural Brain Research, 2020) [Artigo]
Chemical inhibition and nitrergic stimulation of the left and right medial prefrontal cortex (L and RmPFC), respectively, provoke anxiety in mice. Moreover, LmPFC inhibition immediately followed by a single social defeat ... -
Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis
(Cell Metabolism, 2020) [Artigo]COVID-19 can result in severe lung injury. It remained to be determined why diabetic individuals with uncontrolled glucose levels are more prone to develop the severe form of COVID-19. The molecular mechanism underlying ... -
A fast-multiclass method for the determination of 21 endocrine disruptors in human urine by using vortex-assisted dispersive liquid-liquid microextraction (VADLLME) and LC-MS/MS
; ; ; de Oliveira, Anderson Rodrigo Moraes; ; (Environmental Research, 2020) [Artigo]
Simplicity, speed, and reduced cost are essential demands for routine analysis in human biomonitoring studies. Moreover, the availability of higher volumes of human specimens is becoming more restrictive due to ethical ... -
Cisplatin treatment modulates Annexin A1 and inhibitor of differentiation to DNA 1 expression in cervical cancer cells
Prates, Janesly; ; ; Biselli, Joice Matos ; ; ; ; Rodrigues-Lisoni, Flávia Cristina ; Oliani, Sonia Maria (Biomedicine and Pharmacotherapy, 2020) [Artigo]
Cisplatin (Cis) is a choice chemotherapy approach to cervical cancer by inducing DNA adducts and subsequent apoptosis. We have investigated the effects of Cis on Annexin A1 (ANXA1) and inhibitor of DNA binding 1 (ID1) ... -
Prediction of seriniquinone-drug interactions by in vitro inhibition of human cytochrome P450 enzymes
; ; ; ; ; ; ; de Oliveira, Anderson Rodrigo Moraes (Toxicology in Vitro, 2020) [Artigo]
Seriniquinone is a secondary metabolite isolated from a rare marine bacterium of the genus Serinicoccus. This natural quinone is highlighted for its selective cytotoxic activity toward melanoma cancer cells, in which rapid ... -
A possible solution to model nonlinearity in elimination and distributional clearances with α2-adrenergic receptor agonists: Example of the intravenous detomidine and methadone combination in sedated horses
; ; Pacca Loureiro Luna, Stelio; Rodrigues de Oliveira, Alice ; Werneck Fonseca, Mariana ; ; ; (Journal of Veterinary Pharmacology and Therapeutics, 2019) [Artigo]
The alpha(α)2-agonist detomidine is used for equine sedation with opioids such as methadone. We retrieved the data from two randomized, crossover studies where detomidine and methadone were given intravenously alone or ... -
Parkinson’s disease: A review from pathophysiology to treatment
; ; ; ; Padilha, Elias C.; ; ; (Mini-Reviews in Medicinal Chemistry, 2020) [Resenha]
Parkinson's Disease (PD) is the second most common neurodegenerative disease in the elderly population, with a higher prevalence in men, independent of race and social class; it affects approximately 1.5 to 2.0% of the ... -
Simple and Rapid Method by Ultra High-Performance Liquid Chromatography (UHPLC) with Ultraviolet Detection for Determination of Efavirenz in Plasma: Application in a Preclinical Pharmacokinetic Study
Dos Santos Martins, Evelin; Oliveira, Jonata Augusto ; Franchin, Taísa Busaranho ; Silva, Bruna Cristina Ulian ; Cândido, Caroline Damico ; Peccinini, Rosângela Gonçalves (Journal of Chromatographic Science, 2019) [Artigo]
A simple and rapid ultra-high-performance liquid chromatography (UHPLC) method for determination of efavirenz (EFV) in plasma was developed and applied in a preclinical pharmacokinetic study. The method involves only ... -
Water Dilutes and Alcohol Concentrates Urinary Arsenic Species When Food is the Dominant Source of Exposure
de Moraes, Natalia V.; ; ; ; ; ; ; ; (Exposure and Health, 2019) [Artigo]
Exposure to certain arsenic (As) species has been associated with increased cancer risk and a wide range of other health concerns, even at low levels. Here we used urine as a biomarker of As internal dose in a well-characterized ... -
Surface composition and catalytic activity of an iron mining residue for simultaneous degradation of sulfonamide antibiotics
Ayala-Durán, Saidy C.; Hammer, Peter ; Pupo Nogueira, Raquel F. (Environmental Science and Pollution Research, 2020) [Artigo]
Iron mining residue was evaluated as a potential catalyst for heterogeneous Fenton/photo-Fenton degradation of sulfonamide antibiotics. The residue contained 25% Fe2O3 and 8% CeO2, as determined by X-ray fluorescence ... -
Photoelectrodes of Cu2O with interfacial structure of topological insulator Bi2Se3 contributes to selective photoelectrocatalytic reduction of CO2 towards methanol
; ; Brito, Juliana Ferreira de; ; Boldrin Zanoni, Maria Valnice ; (Journal Of Co2 Utilization, 2020) [Artigo]
Artificial photosynthesis emerges as feasible solution to diminish CO2 content in the atmosphere. Photoelectrocatalysis can diminish CO2 concentration while generating useful resources such as methanol. Here an alternative ... -
Preparation of FTO/CU2O Electrode Protected by PEDOT:PSS and Its Better Performance in the Photoelectrocatalytic Reduction of CO2 to Methanol
; Irikura, Kallyni; ; ; ; Boldrin Zanoni, Maria Valnice (Electrocatalysis, 2020) [Artigo]
Copper(I) oxide (Cu2O) was electrochemically deposited on fluorine-doped tin oxide (FTO) glass electrode and covered with a thin layer of poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS). The electrode ... -
Antidiabetic activity of Musa x paradisiaca extracts in streptozotocin-induced diabetic rats and chemical characterization by HPLC-DAD-MS
; Figueiredo, I. D.; Baviera, A. M. ; ; ; Oliveira, J. A. ; Peccinini, R. G. ; ; (Journal Of Ethnopharmacology, 2020) [Artigo]
Ethnopharmacological relevance: The Musa x paradisiaca L. inflorescence, known as banana blossom or banana heart, is used in traditional medicine for the treatment of diabetes mellitus. Aim of the study: The aim of the ... -
Assessment of the hypoglycemic effect of Bixin in alloxan-induced diabetic rats: in vivo and in silico studies
; ; ; Padilha, Elias Carvalho; ; ; ; ; ; et al. (Journal Of Biomolecular Structure & Dynamics, 2020) [Artigo]
The objectives of this study were to extract and purify Bixin from the seeds of Bixa orellana and to evaluate its hypoglycemic activity in vivo, as well as, to conduct an in silico study of selectivity on peroxisome ... -
Sandwich Nylon/stainless-steel/WO3 membrane for the photoelectrocatalytic removal of Reactive Red 120 dye applied in a flow reactor
Martins, Alysson Stefan; ; Boldrin Zanoni, Maria Valnice (Separation And Purification Technology, 2020) [Artigo]
Coupling photocatalysis and filtration has emerged as an attractive alternative to improve the performance and minimize effects inherent to current technologies used for wastewater treatment. Herein, we report the preparation ... -
Pharmacokinetic disposition of erythraline in rats after intravenous administration
; ; ; ; Moraes, Natalia V. de; ; ; ; (Revista Brasileira De Farmacognosia-brazilian Journal Of Pharmacognosy, 2019) [Artigo]
Erythraline is the major alkaloid produced by Erythrina verna Vell., Fabaceae, a plant used in folk medicine and phytotherapeutic products to treat anxiety and sleep disorders. This study aimed to investigate the pharmacokinetic ... -
Prolonged Exposure to Alcohol Vapor Causes Change in Cardiovascular Function in Female but not in Male Rats
Bianchi, Paula Cristina; Costa Ferreira, Willian ; ; ; Carneiro de Oliveira, Paulo Eduardo ; Gomes de Souza, Lucas ; Crestani, Carlos César ; ; da Silva Planeta, Cleopatra ; et al. (Alcoholism: Clinical and Experimental Research, 2019) [Artigo]
Background: Alcohol abuse is a health concern worldwide. Studies have associated alcohol abuse with cardiovascular impairments. In this study, we investigated differences in the effects of chronic alcohol vapor exposure ...