RSS 1.0Artigos - Princípios Ativos Naturais e Toxicologia - FCFAR
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Daily Optogenetic Stimulation of the Left Infralimbic Cortex Reverses Extinction Impairments in Male Rats Exposed to Single Prolonged Stress
Canto-de-Souza, Lucas
; ; ; ; ; ; Nunes-de-Souza, Ricardo Luiz ; ; Planeta, Cleopatra Silva ; (Frontiers in Behavioral Neuroscience, 2021) [Artigo]
Post-traumatic stress disorder (PTSD) is associated with decreased activity in the prefrontal cortex. PTSD-like pathophysiology and behaviors have been observed in rodents exposed to a single prolonged stress (SPS) procedure. ... -
Behavioral, hormonal, and neural alterations induced by social contagion for pain in mice
Baptista-de-Souza, Daniela; Rodrigues Tavares, Lígia Renata ; Canto-de-Souza, Lucas ; Nunes-de-Souza, Ricardo Luiz ; Canto-de-Souza, Azair (Neuropharmacology, 2022) [Artigo]
Neurobiology of social contagion/empathy aims to collaborate with the development of treatments for human disorders characterized by the absence of this response – autism spectrum disorder, schizophrenia, and antisocial ... -
Glutamatergic Neurotransmission Controls the Functional Lateralization of the mPFC in the Modulation of Anxiety Induced by Social Defeat Stress in Male Mice
Santos-Costa, Nathália; Baptista-de-Souza, Daniela ; Canto-de-Souza, Lucas ; Fresca da Costa, Vinícius ; Nunes-de-Souza, Ricardo Luiz (Frontiers in Behavioral Neuroscience, 2021) [Artigo]
The rodent medial prefrontal cortex (mPFC) is anatomically divided into cingulate (Cg1), prelimbic (PrL), and infralimbic (IL) subareas. The left and right mPFC (L and RmPFC) process emotional responses induced by ... -
5-HT3 receptor within the amygdaloid complex modulates pain hypersensitivity induced by empathy model of cohabitation with a partner in chronic pain condition in mice
Rodrigues Tavares, Lígia Renata; Pelarin, Vinícius ; Baptista-de-Souza, Daniela ; ; Nunes-de-Souza, Ricardo Luiz ; Canto-de-Souza, Azair (Social Neuroscience, 2021) [Artigo]
Cohabitation with a partner undergoing chronic pain induces pain hypersensitivity. Among a lot of other neurochemical pathways, the serotonin (5-HT) role, specifically the 5-HT3 receptor (5-HT3R), in the amygdala has never ... -
Anxiolytic-like effects of erythrinian alkaloids from erythrina suberosa
Serrano, Maria Amélia Rodrigues; De Luca Batista, Andrea Nastri ; Da Silva Bolzani, Vanderlan ; De Ávila Santos, Luciana ; De Campos Nogueira, Paulo José ; Nunes-De-Souza, Ricardo Luiz ; ; (Quimica Nova, 2011) [Artigo]
Two alkaloids, erysodine (1) and erysothrine (2) were isolated from the flowers of a Pakistani medicinal plant, Erythrina suberosa. These compounds were investigated for anxiolytic properties, and the results showed ... -
Role of nitric oxide in the periaqueductal gray in defensive behavior in mice: Influence of prior local N- methyl-D-aspartate receptor activation and aversive condition
Nunes-de-Souza, Ricardo Luiz; Miguel, Tarciso Tadeu ; Gomes, Karina Santos ; Fugimoto, Juliana Sayuri ; Mendes-Gomes, Joyce ; Amaral, Vanessa Cristiane Santana ; (Psychology and Neuroscience, 2010) [Artigo]
Glutamate N-methyl-D-aspartate (NMDA) receptor activation within the dorsal column of the periaqueductal gray (dPAG) leads to antinociceptive, autonomic, and behavioral responses characterized as the fear reaction. Activation ... -
Gold(III) heteroleptic complexes with SNS-thiosemicarbazonate ligands as cytotoxic agents: Experimental and computational insights into the mechanism of action
; ; ; de Oliveira Lopes, Érica; Rogério Pavan, Fernando ; ; ; ; ; et al. (Polyhedron, 2022) [Artigo]
New gold(III) heteroleptic complexes of general formula [AuX(dmtsc)], with (dmtsc)2– = (diethylaminothiocarbonyl)benzimidoyl-morpholinyl-thiosemicarbazonate and X = xant– (ethyl xanthate) or damp– (dimethyl-1-phenylmethanamine), ... -
In vitro-in vivo correlation of the chiral pesticide prothioconazole after interaction with human CYP450 enzymes
; ; ; ; Moraes de Oliveira, Anderson Rodrigo (Food and Chemical Toxicology, 2022) [Artigo]
Growing human demand for food has culminated in increased use of pesticides worldwide. Prothioconazole (PTC), a profungicide, is bioactivated by metabolic PTC oxidation to prothioconazole-desthio (D-PTC). Here, the in vitro ... -
Decreased mir-497-5p suppresses il-6 induced atrophy in muscle cells
Freire, Paula P.; Cury, Sarah S. ; Lopes, Letícia O. ; Fernandez, Geysson J. ; ; de Moraes, Leonardo Nazario ; de Oliveira, Grasieli ; Oliveira, Jakeline S. ; de Moraes, Diogo ; et al. (Cells, 2021) [Artigo]
Interleukin-6 (IL-6) is a pro-inflammatory cytokine associated with skeletal muscle wasting in cancer cachexia. The control of gene expression by microRNAs (miRNAs) in muscle wasting involves the regulation of thousands ... -
MHC Variants Associated With Symptomatic Versus Asymptomatic SARS-CoV-2 Infection in Highly Exposed Individuals
Castelli, Erick C.; ; ; ; Silva, Nayane S. B. ; Andrade, Heloisa S. ; Souza, Andreia S. ; Pereira, Raphaela N. ; Castro, Camila F. B. ; et al. (Frontiers in Immunology, 2021) [Artigo]
Despite the high number of individuals infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who develop coronavirus disease 2019 (COVID-19) symptoms worldwide, many exposed individuals remain asymptomatic ... -
TLR4 deletion increases basal energy expenditure and attenuates heart apoptosis and ER stress but mitigates the training-induced cardiac function and performance improvement
; ; ; ; ; ; Tavares, Maria Eduarda de A.; Teixeira, Giovana R. ; ; et al. (Life Sciences, 2021) [Artigo]
Strategies capable of attenuating TLR4 can attenuate metabolic processes such as inflammation, endoplasmic reticulum (ER) stress, and apoptosis in the body. Physical exercise has been a cornerstone in suppressing inflammation ... -
Enantioselective inhibition of human CYP2C19 by the chiral pesticide ethofumesate: Prediction of pesticide-drug interactions in humans
; ; ; ; ; ; Moraes de Oliveira, Anderson Rodrigo (Chemico-Biological Interactions, 2021) [Artigo]
Ethofumesate is a chiral herbicide that may display enantioselective behavior in humans. For this reason, the enantioselective potential of ethofumesate and its main metabolite ethofumesate-2-hydroxy to cause pesticide-drug ... -
Bellis perennis extract mitigates UVA-induced keratinocyte damage: Photoprotective and immunomodulatory effects
; ; ; ; Corrêa, Mab P.; ; Gil, Cristiane D. (Journal of Photochemistry and Photobiology B: Biology, 2021) [Artigo]
A need exists for further research elucidating the benefits of environmentally safe photoprotective agents against ultraviolet (UV) exposure, and plant extracts represent a human-friendly alternative formulation. This study ... -
Characterization of Casearin X Metabolism by Rat and Human Liver Microsomes
(Planta Medica, 2019) [Artigo]Casearin X (CAS X) is the major clerodane diterpene isolated from the leaves of Casearia sylvestris and has been extensively studied due to its powerful cytotoxic activity at low concentrations. Promising results for in ... -
Complete genome sequence of linezolid-susceptible Staphylococcus haemolyticus Sh29/312/L2, a clonal derivative of a linezolid-resistant clinical strain
; ; ; ; ; ; ; ; da Silva, Joás L.; et al. (Genome Announcements, 2015) [Artigo]
We report the whole-genome sequence (WGS) of an in vitro susceptible derivative revertant mutant from a bloodstream isolate involved in a nosocomial outbreak in Brazil. TheWGScomprises 2.5Mbwith 2,500 protein-coding ... -
Overtraining is associated with DNA damage in blood and skeletal muscle cells of Swiss mice
; Pauli, José Rodrigo; ; ; ; ; ; ; ; et al. (BMC Physiology, 2013) [Artigo]
Background: The alkaline version of the single-cell gel (comet) assay is a useful method for quantifying DNA damage. Although some studies on chronic and acute effects of exercise on DNA damage measured by the comet assay ... -
Alpha and beta adrenergic blocker-resistant release of fibrinolytic activity from rat venae cavae by epinephrine in vitro
(Thrombosis and Haemostasis, 1983) [Carta] -
Biofortification quality in bananas monitored by energy-dispersive X-ray fluorescence and chemometrics
Sperança, Marco Aurelio; Mayorquín-Guevara, Juan Esteban ; da Cruz, Mara Cristina Pessoa ; de Almeida Teixeira, Gustavo Henrique ; Pereira, Fabíola Manhas Verbi (Food Chemistry, 2021) [Artigo]
Biofortification is a nutritional strategy used to enhance nutrients in a variety of staple foods. As bananas and plantains (Musa spp.) are considered staple food in many developing countries, monitoring zinc (Zn) content ... -
Development of instrument to report and assess causality of adverse events related to herbal medicines
de Carvalho Mastroianni, Patrícia; Rossi Varallo, Fabiana ; Amaral Costa, Marília ; Da Silva Sacramento, Luis Vitor (Vitae, 2017) [Artigo]
Background: The use of herbal medicines is justified empirically using ethnopharmacological knowledge, which has limitations. Reports of adverse events (AE) may contribute for safety, quality, and effectiveness assessment. ... -
A review of pharmacokinetic parameters of metabolites and prodrugs
de Campos, Michel Leandro; Padilha, Elias Carvalho ; Peccinini, Rosângela Gonçalves (Drug Metabolism Letters, 2013) [Resenha]
In drug discovery and development, the kinetic study of active metabolites plays an important role, helping to define the time course of the drug in the body and its activity or toxicity. After a pharmacokinetics assessment ...