RSS 1.0Artigos - Princípios Ativos Naturais e Toxicologia - FCFAR
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Prolonged Exposure to Alcohol Vapor Causes Change in Cardiovascular Function in Female but not in Male Rats
Bianchi, Paula Cristina
; Costa Ferreira, Willian ; ; ; Carneiro de Oliveira, Paulo Eduardo ; Gomes de Souza, Lucas ; Crestani, Carlos César ; ; da Silva Planeta, Cleopatra ; et al. (Alcoholism: Clinical and Experimental Research, 2019) [Artigo]
Background: Alcohol abuse is a health concern worldwide. Studies have associated alcohol abuse with cardiovascular impairments. In this study, we investigated differences in the effects of chronic alcohol vapor exposure ... -
Glutamate and GABA neurotransmission are increased in paraventricular nucleus of hypothalamus in rats induced to 6-OHDA parkinsonism: Involvement of nNOS
; ; ; ; ; ; ; Crestani, Carlos Cesar; ; (Acta Physiologica, 2019) [Artigo]
Aim: Parkinson's disease (PD) is a progressive neurodegenerative disease that manifests itself clinically after reaching an advanced pathological stage. Besides motor signals, PD patients present cardiovascular and autonomic ... -
Algicidal effect of blue light on pathogenic Prototheca species
; ; ; ; ; Ribeiro, Marcio Garcia; ; (Photodiagnosis and Photodynamic Therapy, 2019) [Artigo]
Prototheca spp. are pathogenic algae with important zoonotic potential. Most importantly, these algae often infect dairy cattle. Since there is no effective therapy against the algae, the standard recommendation is the ... -
In vitro anti-Trypanosoma cruzi activity of ternary copper(II) complexes and in vivo evaluation of the most promising complex
(Biomedicine and Pharmacotherapy, 2019) [Artigo]In order to improve the previously observed antichagasic activity of Cu(II) complexes containing 2-chlorobenzhydrazide (2-CH), we report herein the synthesis and anti-Trypanosoma cruzi activity of novel copper complexes ... -
A new HPLC–MS/MS method for the simultaneous quantification of SGLT2 inhibitors and metformin in plasma and its application to a pharmacokinetic study in healthy volunteers
; ; ; ; Peccinini, Rosângela Gonçalves; (Biomedical Chromatography, 2019) [Artigo]
Monitoring the plasma concentrations of metformin and sodium-glucose cotransporter-2 inhibitors (canagliflozin, dapagliflozin and empagliflozin) is essential for pharmacokinetic and bioequivalence studies and therapeutic ... -
Design, synthesis and pharmacological evaluation of CVIB, a codrug of carvacrol and ibuprofen as a novel anti-inflammatory agent
(International Immunopharmacology, 2019) [Artigo]The search for new drugs with anti-inflammatory properties remains a challenge for modern medicine. Among the various strategies for drug discovery, deriving new chemical entities from known bioactive natural and/or synthetic ... -
Novel nanostructure obtained from pacamã, Lophiosilurus alexandri, skin mucus presents potential as a bioactive carrier in fish
; ; ; Fraceto, Leonardo Fernandes; ; ; de Andrade Belo, Marco Antonio ; (Aquaculture, 2019) [Artigo]
Nanoparticles to delivery drugs and immunomodulatory substances in fish have been widely studied by several research groups. In general, these nanoparticles are polymers, ceramic, fullerenes and metal derivates which can ... -
Acidic and hepatic derivatives of bioactive clerodane diterpenes casearins J and O
Oda, Fernando Bombarda; ; ; Orlando, Allan Botinhon ; de Medeiros, Alexandra Ivo ; ; dos Santos, André Gonzaga (Fitoterapia, 2019) [Artigo]
Clerodane diterpenes from Casearia sylvestris are antiulcerogenic and anti-inflammatory. The finding that they may undergo acid degradation or hepatic metabolization led to an investigation of their degradation products. ... -
UPLC-HRMS and NMR applied in the evaluation of solid-phase extraction methods as a rational strategy of dereplication of Phyllanthus spp. aiming at the discovery of cytotoxic metabolites
; ; ; dos Santos, André Gonzaga; ; ; ; ; ; et al. (Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2019) [Artigo]
The classical approach to drug discovery from natural products (NP's) requires strenuous and complex purification steps for the isolation and structural elucidation. Modern strategies as dereplication aim to accelerate the ... -
Intravaginal delivery of syngonanthus nitens (Bong.) Ruhland fraction based on a nanoemulsion system applied to vulvovaginal candidiasis treatment
dos Santos Ramos, Matheus Aparecido; Da Silva, Patrícia Bento ; De Toledo, Luciani Gaspar ; Oda, Fernando Bombarda ; Da Silva, Isabel Cristiane ; dos Santos, Lourdes Campaner ; dos Santos, André Gonzaga ; ; Pavan, Fernando Rogério ; Chorilli, Marlus et al. (Journal of Biomedical Nanotechnology, 2019) [Artigo]
In this study, was evaluated the chemical composition of a fraction from Syngonanthus nitens extract and its antimicrobial potential unloaded (Fr3) and loaded (F9Fr3) into a nanoemulsion (F9) composed of cholesterol as the ... -
ABCG2 c.421C>A polymorphism alters nifedipine transport to breast milk in hypertensive breastfeeding women
Malfará, Bianca Nayra; ; ; Zanelli, Cleslei Fernando ; ; ; de Moraes, Natália Valadares (Reproductive Toxicology, 2019) [Artigo]
Nifedipine, a known substrate to breast cancer resistance protein (ABCG2/BCRP), is used for the treatment of hypertension during breastfeeding. This study aimed to evaluate the effect of ABCG2 c.421C>A on nifedipine transfer ... -
In vitro and in vivo anti-Helicobacter pylori activity of Casearia sylvestris leaf derivatives
Spósito, Larissa; Oda, Fernando Bombarda ; Vieira, Júlia Hunger ; Carvalho, Flávio Alexandre ; dos Santos Ramos, Matheus Aparecido ; de Castro, Rogério Cardoso ; ; ; Santos, André Gonzaga ; da Silva, Patrícia Bento et al. (Journal of Ethnopharmacology, 2019) [Artigo]
Ethnopharmacological relevance: The number of bacterial strains that are resistant to multiple conventional antimicrobial agents is increasing. In this context, natural products have been widely used as a strategy to treat ... -
Nitrergic neurotransmission in the paraventricular nucleus of the hypothalamus modulates autonomic, neuroendocrine and behavioral responses to acute restraint stress in rats
; Crestani, Carlos C.; ; ; ; ; (Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2019) [Artigo]
We investigated the involvement of nitrergic neurotransmission within the paraventricular nucleus of the hypothalamus (PVN) in modulation of local neuronal activation, autonomic and neuroendocrine responses and behavioral ... -
Pharmacogenetics-based population pharmacokinetic analysis of gabapentin in patients with chronic pain: Effect of OCT2 and OCTN1 gene polymorphisms
Yamamoto, Priscila A.; ; ; ; ; Zanelli, Cleslei F. ; de Moraes, Natália V. (Basic and Clinical Pharmacology and Toxicology, 2019) [Artigo]
Gabapentin (GAB) is eliminated unchanged in urine, and organic cation transporters (OCT2 and OCTN1) have been shown to play a role in GAB renal excretion. This prospective clinical study aimed to evaluate the genetic ... -
In vitro activities of glycoalkaloids from the Solanum lycocarpum against Leishmania infantum
Clementino, Leandro da Costa; Velásquez, Angela Maria Arenas ; Passalacqua, Thais Gaban ; de Almeida, Leticia ; Graminha, Marcia A.S. ; ; ; ; ; Moreira, Raquel R.D. (Brazilian Journal of Pharmacognosy, 2018) [Artigo]
Leishmania infantum is an etiologic agent of visceral leishmaniasis. This disease is a neglected disease that can be fatal if not treated and additionally, the few therapeutic option present several drawbacks, including ... -
POTENTIOMETRIC SENSOR BASED ON SILVER SULFIDE NANOPARTICLES SUPPORTED IN CARBONACEOUS MATERIAL FOR THE DETECTION OF FREE CYANIDE
; Wong, Ademar; Sotomayor, Maria Del Pilar T. ; ; (Quimica Nova, 2019) [Artigo]
Two sensors were synthesized for the detection of free cyanide (CN-), based on silver sulfide nanoparticles (Np-Ag2S) supported on Multiwall Carbon Nanotubes (MWCNT) and hierarchical porous carbon (HPC). The Ag2S/HPC400 ... -
Application of in vitro Drug Metabolism Studies in Chemical Structure Optimization for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP)
Padilha, Elias C.; ; ; ; ; ; ; ; Peccinini, Rosangela G. ; et al. (Frontiers In Pharmacology, 2019) [Artigo]
Currently no approved treatment exists for fibrodysplasia ossificans progressiva (FOP) patients, and disease progression results in severe restriction of joint function and premature mortality. LDN-193189 has been demonstrated ... -
Simultaneous degradation of hexazinone and diuron using ZrO2-nanostructured gas diffusion electrode
; ; ; ; ; ; Bertazzoli, Rodnei; Lanza, Marcos R. V. (Chemical Engineering Journal, 2018) [Artigo]
Although several authors have reported the treatment of diuron in wastewater by advanced oxidative processes (AOPs), only a handful of investigations reported using commercial herbicides composed of a mixture of active ... -
Interplay between 5-HT2C and 5-HT1A receptors in the dorsal periaqueductal gray in the modulation of fear-induced antinociception in mice
Baptista-de-Souza, Daniela; Pelarin, Vinícius ; Canto-de-Souza, Lucas ; Nunes-de-Souza, Ricardo Luiz ; Canto-de-Souza, Azair (Neuropharmacology, 2018) [Artigo]
The confinement of rodents to the open arm of the elevated-plus maze provokes antinociception (OAA). As a type of defensive reaction, the OAA has been investigated through systemic and intramesencephalic (e.g., dorsal ... -
Amygdaloid involvement in the defensive behavior of mice exposed to the open elevated plus-maze
Sorregotti, Tatiani; Cipriano, Ana Cláudia ; ; Mascarenhas, Diego Cardozo ; ; Nunes-de-Souza, Ricardo Luiz (Behavioural Brain Research, 2018) [Artigo]
Previous studies have shown that the exposure to an open elevated plus maze (oEPM, an EPM with all four open arms) elicits fear/anxiety-related responses in laboratory rodents. However, very little is known about the ...