• Interplay between 5-HT2C and 5-HT1A receptors in the dorsal periaqueductal gray in the modulation of fear-induced antinociception in mice 

  Baptista-de-Souza, Daniela ; Pelarin, Vinícius ; Canto-de-Souza, Lucas ; Nunes-de-Souza, Ricardo Luiz ; Canto-de-Souza, Azair (Neuropharmacology, 2018) [Artigo]

  The confinement of rodents to the open arm of the elevated-plus maze provokes antinociception (OAA). As a type of defensive reaction, the OAA has been investigated through systemic and intramesencephalic (e.g., dorsal ...

• Amygdaloid involvement in the defensive behavior of mice exposed to the open elevated plus-maze 

  Sorregotti, Tatiani ; Cipriano, Ana Cláudia ; Cruz, Fábio Cardoso; Mascarenhas, Diego Cardozo ; Rodgers, Robert John; Nunes-de-Souza, Ricardo Luiz (Behavioural Brain Research, 2018) [Artigo]

  Previous studies have shown that the exposure to an open elevated plus maze (oEPM, an EPM with all four open arms) elicits fear/anxiety-related responses in laboratory rodents. However, very little is known about the ...

• CRF receptor type 1 (but not type 2) located within the amygdala plays a role in the modulation of anxiety in mice exposed to the elevated plus maze 

  Cipriano, Ana Cláudia ; Gomes, Karina Santos ; Nunes-de-Souza, Ricardo Luiz (Hormones and Behavior, 2016) [Artigo]

  The amygdala (Amy) is an important center that processes threatening stimuli. Among the neurotransmitters implicated in the control of emotional states, the corticotrophin releasing factor (CRF) is an important modulator, ...

• Annexin A12-26 treatment improves skin heterologous transplantation by modulating inflammation and angiogenesis processes 

  Lacerda, Jéssica Zani ; Drewes, Carine Cristiane; Mimura, Kallyne Kioko Oliveira; Zanon, Caroline de Freitas ; Ansari, Tahera; Gil, Cristiane Damas; Greco, Karin Vicente; Farsky, Sandra Helena Poliselli; Oliani, Sonia Maria (Frontiers in Pharmacology, 2018) [Artigo]

  Skin graft successful depends on reduction of local inflammation evoked by the surgical lesion and efficient neovascularization to nutrition the graft. It has been shown that N-terminal portion of the Annexin A1 protein ...

• Phylogenetic and antimicrobial resistance gene analysis of Salmonella Typhimurium strains isolated in Brazil by whole genome sequencing 

  Almeida, Fernanda; Seribelli, Amanda Aparecida; Cazentini Medeiros, Marta Inês; Rodrigues, Dália dos Prazeres; De MelloVarani, Alessandro ; Luo, Yan; Allard, Marc W.; Falcão, Juliana Pfrimer (PLoS ONE, 2018) [Artigo]

  Whole genome sequencing (WGS) has been used as a powerful technology for molecular epidemiology, surveillance, identification of species and serotype, identification of the sources of outbreaks, among other purposes. In ...

• A perspective of mitochondrial dysfunction in rats treated with silver and titanium nanoparticles (AgNPs and TiNPs) 

  Pereira, Lilian Cristina ; Pazin, Murilo; Franco-Bernardes, Mariana Furio; Martins, Airton da Cunha; Barcelos, Gustavo Rafael Mazzaron; Pereira, Márcio Cesar; Mesquita, João Paulo; Rodrigues, Jairo Lisboa; Barbosa, Fernando; Dorta, Daniel Junqueira (Journal of Trace Elements in Medicine and Biology, 2018) [Artigo]

  Nanotechnology is a growing branch of science that deals with the development of structural features bearing at least one dimension in the nano range. More specifically, nanomaterials are defined as objects with dimensions ...

• Modulation of miR-26a-5p and miR-15b-5p exosomal expression associated with clopidogrel-induced hepatotoxicity in HepG2 cells 

  de Freitas, Renata C. Costa; Bortolin, Raul H.; Lopes, Mariana B.; Tamborlin, Letícia; Meneguello, Letícia ; Silbiger, Vivian N.; Hirata, Rosario D.C.; Hirata, Mário H.; Luchessi, Augusto D. ; Luchessi, André D. (Frontiers in Pharmacology, 2017) [Artigo]

  Clopidogrel is an essential antiplatelet drug used to prevent thrombosis complications associated with atherosclerosis. However, hepatotoxicity is a potential adverse effect related to clopidogrel therapy. Exosome-derived ...

• Mate tea (Ilex paraguariensis) improves bone formation in the alveolar socket healing after tooth extraction in rats 

  Brasilino, Matheus da Silva ; Stringhetta-Garcia, Camila Tami ; Pereira, Camila Scacco ; Pereira, Ariana Aparecida Ferreira ; Stringhetta, Karina; Leopoldino, Andréia Machado; Crivelini, Marcelo Macedo ; Ervolino, Edilson ; Dornelles, Rita Cássia Menegati ; de Melo Stevanato Nakamune, Ana Cláudia et al. (Clinical Oral Investigations, 2018) [Artigo]

  Objectives: The objective of this study was to investigate the effects of mate tea (MT) [Ilex paraguariensis] on alveolar socket healing after tooth extraction. Materials and methods: Sixteen male rats were divided into ...

• llex paraguariensis decreases oxidative stress in bone and mitigates the damage in rats during perimenopause 

  Pereira, Camila Scacco ; Stringhetta-Garcia, Camila Tami ; da Silva Xavier, Lilian ; Tirapeli, Keny Gonçalves ; Pereira, Ariana Aparecida Ferreira ; Kayahara, GiselIi Mitsuy ; Tramarim, José Marcelo ; Crivelini, Marcelo Macedo ; Padovani, Karina Stringhetta; Leopoldino, Andréia Machado et al. (Experimental Gerontology, 2017) [Artigo]

  During perimenopause, oxidative stress increases, which may result in disruption of bone turnover, and consequently in osteoporosis. The use of antioxidants may be an effective nutritional approach to reducing osteoporosis ...

• Exposure to BDE-153 induces autophagy in HepG2 cells 

  Pereira, Lilian Cristina ; Duarte, Filipe Valente; Varela, Ana Teresa Inácio Ferreira; Rolo, Anabela Pinto; Palmeira, Carlos Manuel Marques; Dorta, Daniel Junqueira (Toxicology in Vitro, 2017) [Artigo]

  Autophagy is a pro-survival process that occurs under stressful “life-threatening” conditions. This process clears the cells of damaged organelles, long-lived proteins, and/or misfolded proteins. Under stressful conditions, ...

• Recombinant L-asparaginase 1 from Saccharomyces cerevisiae: An allosteric enzyme with antineoplastic activity 

  Costa, Iris Munhoz; Schultz, Leonardo ; De Araujo Bianchi Pedra, Beatriz; Leite, Mariana Silva Moreira; Farsky, Sandra H. P.; De Oliveira, Marcos Antonio ; Pessoa, Adalberto; Monteiro, Gisele (Scientific Reports, 2016) [Artigo]

  L-asparaginase (L-ASNase) (EC 3.5.1.1) is an important enzyme for the treatment of acute lymphoblastic leukaemia. Currently, the enzyme is obtained from bacteria, Escherichia coli and Erwinia chrysanthemi. The bacterial ...

• Immunological correlates of favorable long-term clinical outcome in multiple sclerosis patients after autologous hematopoietic stem cell transplantation 

  Arruda, Lucas C.M.; de Azevedo, J�lia T.C.; de Oliveira, Gislane L.V.; Scortegagna, Gabriela T.; Rodrigues, Evandra S.; Palma, Patr�cia V.B.; Brum, Doralina G. ; Guerreiro, Carlos T.; Marques, Vanessa D.; Barreira, Amilton A. et al. (Clinical Immunology, 2016) [Artigo]

  High dose immunosuppression followed by autologous hematopoietic stem cell transplantation (AHSCT) induces prolonged clinical remission in multiple sclerosis (MS) patients. However, how patient immune profiles are associated ...

• Polymorphisms in B cell co-stimulatory genes are associated with IgG antibody responses against blood-stage proteins of plasmodium vivax 

  Cassiano, Gustavo C. ; Furini, Adriana A. C.; Capobianco, Marcela P. ; Storti-Melo, Luciane M.; Cunha, Maristela G.; Kano, Flora S.; Carvalho, Luzia H.; Soares, Irene S.; Santos, Sidney E.; Póvoa, Marinete M. et al. (PLoS ONE, 2016) [Artigo]

  The development of an effective immune response can help decrease mortality from malaria and its clinical symptoms. However, this mechanism is complex and has significant inter-individual variation, most likely owing to ...

• Physicochemical characterization by AFM, FT-IR and DSC and biological assays of a promising antileishmania delivery system loaded with a natural Brazilian product 

  Marquele-Oliveira, Franciane; Torres, Elina Cassia; Barud, Hernane da Silva ; Zoccal, Karina Furlani; Faccioli, Lúcia Helena; Hori, Juliana I.; Berretta, Andresa Aparecida (Journal of Pharmaceutical and Biomedical Analysis, 2016) [Artigo]

  The control and treatment of Leishmaniasis, a neglected and infectious disease affecting approximately 12 million people worldwide, are challenging. Leishmania parasites multiply intracellularly within macrophages located ...

• Probiotic soy product supplemented with isoflavones improves the lipid profile of moderately hypercholesterolemic men: A randomized controlled trial 

  Cavallini, Daniela Cardoso Umbelino ; Manzoni, Marla Simone Jovenasso ; Bedani, Raquel; Roselino, Mariana Nougalli ; Celiberto, Larissa Sbaglia ; Vendramini, Regina Célia ; de Valdez, Graciela Font; Abdalla, Dulcinéia Saes Parra; Pinto, Roseli Aparecida ; Rosetto, Daniella et al. (Nutrients, 2016) [Artigo]

  Background: Cardiovascular disease is the leading cause of worldwide morbidity and mortality. Several studies have demonstrated that specific probiotics affect the host’s metabolism and may influence the cardiovascular ...

• Quality evaluation of intact açaí and juçara fruit by means of near infrared spectroscopy 

  Cunha Júnior, Luis Carlos; Teixeira, Gustavo Henrique de Almeida ; Nardini, Viviani; Walsh, Kerry Brian (Postharvest Biology and Technology, 2016) [Artigo]

  The objective of this study was to report the robustness of partial least squares regression (PLSR) models developed using FT-NIR reflectance spectra obtained from intact açaí and juçara fruit. Mature fruit were collected ...

• Alzheimer's disease: A review from the pathophysiology to diagnosis, new perspectives for pharmacological treatment 

  Dos Santos Picanço, Leide Caroline; Ozela, Priscilla F.; Brito, Maiara de Fátima de Brito; Pinheiro, Abraão A.; Padilha, Elias C. ; Braga, Francinaldo S.; da Silva, Carlos Henrique Tomich de Paula; Dos Santos, Cleydson Breno Rodrigues; Rosa, Joaquín M. C.; Hage-Melim, Lorane Izabel da Silva (Current Medicinal Chemistry, 2018) [Resenha]

  Dementia is characterized by the impairment of cognition and behavior of people over 65 years. Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder in the world, as approximately 47 million people are ...

• Nitric oxide alterations in cardiovascular system of rats with Parkinsonism induced by 6-OHDA and submitted to previous exercise 

  de Jager, Lorena; Amorim, Eric Diego Turossi; Lucchetti, Bruno Fernando Cruz; Lopes, Fernanda Novi Cortegoso; Crestani, Carlos Cesar ; Pinge-Filho, Phileno; Martins-Pinge, Marli Cardoso (Life Sciences, 2018) [Artigo]

  Studies showed that physical exercise decreases the risk of developing Parkinson's disease (PD) as slowing its progression. Nitric oxide (NO) increases in the substantia nigra pars compacta (SNpc) of individuals with PD. ...

• New pioglitazone metabolites and absence of opened-ring metabolites in new n-substituted thiazolidinedione 

  Campos, Michel Leandro; Cerqueira, Letícia Bonancio; Silva, Bruna Cristina Ulian ; Franchin, Taísa Busaranho ; Galdino-Pitta, Marina Rocha; Pitta, Ivan Rocha; Peccinini, Rosângela Gonçalves ; Pontarolo, Roberto (Drug Metabolism and Disposition, 2018) [Artigo]

  Thiazolidinediones (TZDs) are drugs used to treat type 2 diabetes mellitus; however, several safety concerns remain regarding the available drugs in this class. Therefore, the search for new TZD candidates is ongoing; ...

• Single aggressive and non-aggressive social interactions elicit distinct behavioral patterns to the context in mice 

  Crestani, Ariela M. ; Cipriano, Ana C. ; Nunes-de-Souza, Ricardo L. (Behavioural Processes, 2018) [Artigo]

  Aggressive interactions between conspecific animals have been used as a social stressor with ethological characteristics to study how social interactions can modulate animal's behavior. Here, a new protocol based on ...

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