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dc.contributor.authorHott, Sara C.
dc.contributor.authorGomes, Felipe V.
dc.contributor.authorFabri, Denise R. S.
dc.contributor.authorReis, Daniel G.
dc.contributor.authorCrestani, Carlos Cesar [UNESP]
dc.contributor.authorCorrea, Fernando M. A.
dc.contributor.authorResstel, Leonardo B. M.
dc.identifier.citationBritish Journal of Pharmacology. Hoboken: Wiley-blackwell, v. 167, n. 1, p. 207-221, 2012.
dc.description.abstractBACKGROUND and PURPOSE The bed nucleus of the stria terminalis (BNST) is a limbic structure that is involved in the expression of conditioned contextual fear. Among the numerous neural inputs to the BNST, noradrenergic synaptic terminals are prominent and some evidence suggests an activation of this noradrenergic neurotransmission in the BNST during aversive situations. Here, we have investigated the involvement of the BNST noradrenergic system in the modulation of behavioural and autonomic responses induced by conditioned contextual fear in rats. EXPERIMENTAL APPROACH Male Wistar rats with cannulae bilaterally implanted into the BNST were submitted to a 10 min conditioning session (6 footshocks, 1.5 ma/ 3 s). Twenty-four hours later freezing and autonomic responses (mean arterial pressure, heart rate and cutaneous temperature) to the conditioning box were measured for 10 min. The adrenoceptor antagonists were administered 10 min before the re-exposure to the aversive context. KEY RESULTS L-propranolol, a non-selective beta-adrenoceptor antagonist, and phentolamine, a non-selective a-adrenoceptor antagonist, reduced both freezing and autonomic responses induced by aversive context. Similar results were observed with CGP20712, a selective beta 1-adrenoceptor antagonist, and WB4101, a selective a1-antagonist, but not with ICI118,551, a selective beta 2-adrenoceptor antagonist or RX821002, a selective a2-antagonist. CONCLUSIONS and IMPLICATIONS These findings support the idea that noradrenergic neurotransmission in the BNST via a1- and beta 1-adrenoceptors is involved in the expression of conditioned contextual fear.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Apoio ao Ensino, Pesquisa e Assistência do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da USP (FAEPA)
dc.relation.ispartofBritish Journal of Pharmacology
dc.sourceWeb of Science
dc.subjectnoradrenergic systemen
dc.subjectadrenoceptor antagonistsen
dc.subjectautonomic responsesen
dc.subjectcardiovascular systemen
dc.subjectconditioned emotional responsesen
dc.titleBoth alpha(1)- and beta(1)-adrenoceptors in the bed nucleus of the stria terminalis are involved in the expression of conditioned contextual fearen
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationUniv São Paulo, Dept Pharmacol, Sch Med, BR-14049900 Ribeirao Preto, SP, Brazil
dc.description.affiliationSão Paulo State Univ, Dept Nat Act Principles & Toxicol, Sch Pharmaceut Sci, UNESP, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Dept Nat Act Principles & Toxicol, Sch Pharmaceut Sci, UNESP, São Paulo, Brazil
dc.rights.accessRightsAcesso restrito
dc.description.sponsorshipIdFAPESP: 11/13299-9
dc.description.sponsorshipIdFAPESP: 10/17343-0
dc.description.sponsorshipIdFAPESP: 09/03187-9
dc.description.sponsorshipIdFAPESP: 11/07332-3
dc.description.sponsorshipIdCNPq: 305996/2008-8
dc.description.sponsorshipIdCNPq: 470042/2009-5
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
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