Now showing items 1-10 of 13
The reactivity of oytho-methoxy-substituted catechol radicals with sulfhydryl groups: Contribution for the comprehension of the mechanism of inhibition of NADPH oxidase by apocynin
(Biochemical Pharmacology, 2007-08-01) [Artigo]
Redox processes are involved in the mechanism of action of NADPH oxidase inhibitors such as diphenyleneiodonium and apocynin. Here, we studied the structure-activity relationship for apocynin and analogous ortho-methoxy- ...
Organochlorine pesticides and polychlorinated biphenyls in soil and water samples in the northeastern part of São Paulo State, Brazil
(Chemosphere, 2006-12-01) [Artigo]
Detailed analyses of persistent organic pollutants (POPs) such as organochlorine pesticides (OCPs), hexachlorocyclohexane (HCH) isomers (HCHs), dichlorodiphenyltrichloro ethane (DDT) and its metabolites (DDTs) and congeners ...
Oxidation of acetylacetone catalyzed by horseradish peroxidase in the absence of hydrogen peroxide
(Biochimica et Biophysica Acta: General Subjects, 2006-12-01) [Artigo]
Horseradish peroxidase (HRP) is a plant enzyme widely used in biotechnology, including antibody-directed enzyme prodrug therapy (ADEPT). Here, we showed that HRP is able to catalyze the autoxidation of acetylacetone in the ...
The effect of pyrazinamide and rifampicin on isoniazid metabolism in rats
(Biopharmaceutics & Drug Disposition, 2007-09-01) [Artigo]
Hepatotoxicity is the main concern during tuberculosis chemotherapy with the first-line drugs isoniazid (INH), rifampicin (RMP) and pyrazinamide (PYR). Since these hepatotoxic events have been associated with INH metabolites, ...
The effect of rifampicin and pyrazinamide on isoniazid pharmacokinetics in rats
(Biopharmaceutics & Drug Disposition, 2007-11-01) [Artigo]
Tuberculosis chemotherapy involves combination of the drugs isoniazid (INH), rifampicin (RMP) and pyrazinamide (PYR) for a 6-month period. The present work investigated the influence of RMP and PYR on the pharmacokinetic ...
Identification of the mechanism of action of eupomatenoid-5 isolated from Piper regnellii var. pallescens on Trypanosoma cruzi
(Planta Medica, 2009-07-01) [Resumo]
The effect of pH on horseradish peroxidase-catalyzed oxidation of melatonin: production of N-1-acetyl-N-2-formyl-5-methoxykynuramine versus radical-mediated degradation
(Journal of Pineal Research, 2007-04-01) [Artigo]
There is a g-rowing body of evidence that melatonin and its oxidation product, N-1-acetyl-N-2-formyl-5-methoxykynuramine (AFMK), have anti-inflammatory properties. From a nutritional point of view, the discovery of melatonin ...
Chemiluminescent determination of leukocyte alkaline phosphatase: An advantageous alternative to the cytochemical assay
(Journal of Clinical Laboratory Analysis, 2007-01-01) [Artigo]
The determination of leukocyte alkaline phosphatasd (LAP) is used as an aid to diagnose many diseases in the laboratory. For example, it can be used to distinguish chronic myeloid leukemia (CML) from other myeloproliferative ...
The co-catalytic effect of chlorpromazine on peroxidase-mediated oxidation of melatonin: enhanced production of N-1-acetyl-N (2)-formyl-5-methoxykynuramine
(Journal of Pineal Research, 2008-03-01) [Artigo]
Accumulating evidence points to relationships between increased production of reactive oxygen or decreased antioxidant protection in schizophrenic patients. Chlorpromazine (CPZ), which remains a benchmark treatment for ...
Oxidation of melatonin by AAPH-derived peroxyl radicals: Evidence of a pro-oxidant effect of melatonin
(Biochimica et Biophysica Acta: General Subjects, 2009-08-01) [Artigo]
Background: Melatonin is well-established as a powerful reducing agent of oxidant generated in the cell medium. We aimed to investigate how readily melatonin is oxidized by peroxyl radicals ROO(-) generated by the thermolysis ...