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Participation of dectin-1 receptor on NETs release against Paracoccidioides brasiliensis: role on extracellular killing
(Immunobiology, 2015-09-14) [Artigo]
Paracoccidioides brasiliensis is a dimorphic fungus from the Paracoccidioides genus, which is the causative agent of paracoccidioidomycosis, a chronic, subacute or acute mycosis, with visceral and cutaneous involvement. ...
Inflammatory response of endothelial cells to hepatitis C virus recombinant envelope glycoprotein 2 protein exposure
(Memórias do Instituto Oswaldo Cruz, 2014-09-01) [Artigo]
The hepatitis C virus (HCV) encodes approximately 10 different structural and non-structural proteins, including the envelope glycoprotein 2 (E2). HCV proteins, especially the envelope proteins, bind to cell receptors and ...
Trypanocidal action of eupomatenoid-5 is related to mitochondrion dysfunction and oxidative damage in Trypanosoma cruzi
(Microbes and Infection, 2011-11-01) [Artigo]
Because of its severe side effects and variable efficacy, the current treatment for Chagas disease is unsatisfactory. Natural compounds are good alternative chemotherapeutic agents for the treatment of this infection. ...
The triad indole-3-acetic acid ethyl ester/esterase/horseradish peroxidase as a new cytotoxic prodrug/enzyme combination
(Applied Cancer Research, 2010) [Artigo]
The antibody-directed enzyme prodrug therapy (ADEPT) is a means of restricting the action of toxic drugs to the tumor site. The enzyme/prodrug pair horseradish peroxidase (HRP)/indole-3-acetic acid (IAA) has been studied ...
Serum myeloperoxidase level is Increased in heavy smokers
(Open Journal of Clinical Diagnostics, 2013) [Artigo]
Raised myeloperoxidase (MPO) serum levels are associated with endothelial dysfunction and cigarette smoking is a risk factor for cardiovascular diseases. Since myocardial infarction is associated with leukocytosis and ...
Dansylglycine, a fluorescent probe for specific determination of halogenating activity of myeloperoxidase and eosinophil peroxidase
(Analytical Biochemistry, 2017-09-01) [Artigo]
Myeloperoxidase (MPO) and eosinophil peroxidase (EPO) are enzymes present in neutrophil and eosinophil leukocytes, respectively. Here, we present the development of a sensitive and specific assay for determination of the ...
Taurine bromamine: Reactivity of an endogenous and exogenous anti-inflammatory and antimicrobial amino acid derivative
(Biomolecules, 2016-04-21) [Artigo]
Taurine bromamine (Tau-NHBr) is produced by the reaction between hypobromous acid (HOBr) and the amino acid taurine. There are increasing number of applications of Tau-NHBr as an anti-inflammatory and microbicidal drug for ...
Induction of axial chirality in divanillin by interaction with bovine serum albumin
(PLoS ONE, 2017-06-01) [Artigo]
Vanillin is a plant secondary metabolite and has numerous beneficial health applications. Divanillin is the homodimer of vanillin and used as a taste enhancer compound and also a promissory anticancer drug. Here, divanillin ...
Alkyl caffeates as anti-helicobacter pylori and scavenger of oxidants produced by neutrophils
(Medicinal Chemistry, 2014-02-01) [Artigo]
Helicobacter pylori pathogenic action involves the colonization of the gastrointestinal tract and a large production of reactive oxygen species (ROS) by the neutrophils attracted to the site of infection. The aim of this ...
Oxidation of Bovine Albumin by Hypochlorous and Hypobromous Acids: Structural and Functional Alterations
(British Journal of Pharmaceutical Research, 2013) [Artigo]
Aims: Hypochlorous (HOCl) and hypobromous (HOBr) acids are among the most powerful oxidants produced by the innate immune cells. Albumin is the predominant protein in most body fluids and is considered the most important ...