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Antioxidant effects of quercetin and naringenin are associated with impaired neutrophil microbicidal activity
(Evidence-based Complementary and Alternative Medicine, 2013-08-20) [Artigo]
Naringenin and quercetin are considered antioxidant compounds with promising activity against oxidative damage in human cells. However, no reports have described their effects on reactive oxygen species (ROS) production ...
Alkaloids extracted from Pterogyne nitens induce apoptosis in malignant breast cell line
(Tumor Biology, 2010-10-01) [Artigo]
In the present study, two alkaloids isolated from Pterogyne nitens, a plant native to Brazil, have been shown to induce apoptosis in human breast cancer cells. These compounds, pterogynine (PGN) and pterogynidine (PGD), ...
Caffeic Acid Phenethyl Ester: Consequences of Its Hydrophobicity in the Oxidative Functions and Cytokine Release by Leukocytes
(Evidence-based Complementary And Alternative Medicine, 2014-01-01) [Artigo]
Numerous anti-inflammatory properties have been attributed to caffeic acid phenethyl ester (CAPE), an active component of propolis. NADPH oxidases are multienzymatic complexes involved in many inflammatory diseases. Here, ...
The reactivity of oytho-methoxy-substituted catechol radicals with sulfhydryl groups: Contribution for the comprehension of the mechanism of inhibition of NADPH oxidase by apocynin
(Biochemical Pharmacology, 2007-08-01) [Artigo]
Redox processes are involved in the mechanism of action of NADPH oxidase inhibitors such as diphenyleneiodonium and apocynin. Here, we studied the structure-activity relationship for apocynin and analogous ortho-methoxy- ...
Organochlorine pesticides and polychlorinated biphenyls in soil and water samples in the northeastern part of São Paulo State, Brazil
(Chemosphere, 2006-12-01) [Artigo]
Detailed analyses of persistent organic pollutants (POPs) such as organochlorine pesticides (OCPs), hexachlorocyclohexane (HCH) isomers (HCHs), dichlorodiphenyltrichloro ethane (DDT) and its metabolites (DDTs) and congeners ...
Oxidation of acetylacetone catalyzed by horseradish peroxidase in the absence of hydrogen peroxide
(Biochimica et Biophysica Acta: General Subjects, 2006-12-01) [Artigo]
Horseradish peroxidase (HRP) is a plant enzyme widely used in biotechnology, including antibody-directed enzyme prodrug therapy (ADEPT). Here, we showed that HRP is able to catalyze the autoxidation of acetylacetone in the ...
Oxidation of melatonin by taurine chloramine
(Journal of Pineal Research, 2010-09-01) [Artigo]
Melatonin is widely known for its antioxidant, immunomodulatory, and anti-inflammatory effects. Hypochlorous acid (HOCl) is one example of an endogenous oxidant that is promptly neutralized by melatonin. Melatonin also ...
Light emission from tryptophan oxidation by hypobromous acid
(Luminescence, 2012-10-08) [Artigo]
The emission of ultraweak light from cells is a phenomenon associated with the oxidation of biomolecules by reactive oxygen species. The indole moiety present in tryptophan, serotonin and melatonin is frequently associated ...
Albumin-induced circular dichroism in Congo red: applications for studies of amyloid-like fibril aggregates and binding sites
(Spectrochimica Acta. Part A, Molecular And Biomolecular Spectroscopy, 2015-11-05) [Artigo]
Congo red (CR), one of the most commonly used dyes for the identification of amyloid fibril aggregates, is also a ligand of native bovine serum albumin (BSA). Induced circular dichroism (ICD) is a phenomenon observed when ...
Vitamin K3 induces antiproliferative effect in cervical epithelial cells transformed by HPV 16 (SiHa cells) through the increase in reactive oxygen species production
(Archives Of Gynecology And Obstetrics, 2016-10-01) [Artigo]
Cervical cancer is characterized as an important public health problem. According to latest estimates, cancer of the cervix is the fourth most common cancer among women. Due to its high prevalence, the search for new and ...