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Vitamin K3 induces antiproliferative effect in cervical epithelial cells transformed by HPV 16 (SiHa cells) through the increase in reactive oxygen species production
(Archives Of Gynecology And Obstetrics, 2016-10-01) [Artigo]
Cervical cancer is characterized as an important public health problem. According to latest estimates, cancer of the cervix is the fourth most common cancer among women. Due to its high prevalence, the search for new and ...
The triad indole-3-acetic acid ethyl ester/esterase/horseradish peroxidase as a new cytotoxic prodrug/enzyme combination
(Applied Cancer Research, 2010) [Artigo]
The antibody-directed enzyme prodrug therapy (ADEPT) is a means of restricting the action of toxic drugs to the tumor site. The enzyme/prodrug pair horseradish peroxidase (HRP)/indole-3-acetic acid (IAA) has been studied ...
Oxidation of amino acids by chlorpromazine cation radical and co-catalysis by chlorpromazine
(Pharmacology and Pharmacy, 2012) [Artigo]
The long-tem use of chlorpromazine (CPZ) may cause severe side effects. This property of CPZ might be related to pro-oxidant effects of the chlorpromazine cation radical (CPZ•+), which can be easily generated by catalytic ...
Facile Synthesis and Photophysical Characterization of New Quinoline Dyes
(Journal of Fluorescence, 2017-01-01) [Artigo]
This paper describes the synthesis of new quinoline derivatives, molecules that has been long interest in the organic and medicinal chemistry. Through the Multicomponent Reaction (MCR), an important tool in modern synthetic ...
Taurine bromamine: Reactivity of an endogenous and exogenous anti-inflammatory and antimicrobial amino acid derivative
(Biomolecules, 2016-04-21) [Artigo]
Taurine bromamine (Tau-NHBr) is produced by the reaction between hypobromous acid (HOBr) and the amino acid taurine. There are increasing number of applications of Tau-NHBr as an anti-inflammatory and microbicidal drug for ...
Microbicidal activity of N-chlorotaurine in combination with hydrogen peroxide
(AMB Express, 2017-12-01) [Artigo]
N-chlorotaurine (NCT) and hydrogen peroxide are powerful endogenous antiseptics. In vivo, the reaction between hydrogen peroxide and metal ions leads to the formation of free hydroxyl radicals, which have an increased ...
The Combination of Vitamin K-3 and Vitamin C Has Synergic Activity against Forms of Trypanosoma cruzi through a Redox Imbalance Process
(Plos One, 2015-12-07) [Artigo]
Chagas' disease is an infection that is caused by the protozoan Trypanosoma cruzi, affecting millions of people worldwide. Because of severe side effects and variable efficacy, the current treatments for Chagas' disease ...
Alkyl caffeates as anti-helicobacter pylori and scavenger of oxidants produced by neutrophils
(Medicinal Chemistry, 2014-02-01) [Artigo]
Helicobacter pylori pathogenic action involves the colonization of the gastrointestinal tract and a large production of reactive oxygen species (ROS) by the neutrophils attracted to the site of infection. The aim of this ...
Oxidation of Bovine Albumin by Hypochlorous and Hypobromous Acids: Structural and Functional Alterations
(British Journal of Pharmaceutical Research, 2013) [Artigo]
Aims: Hypochlorous (HOCl) and hypobromous (HOBr) acids are among the most powerful oxidants produced by the innate immune cells. Albumin is the predominant protein in most body fluids and is considered the most important ...
Induction of axial chirality in divanillin by interaction with bovine serum albumin
(PLoS ONE, 2017-06-01) [Artigo]
Vanillin is a plant secondary metabolite and has numerous beneficial health applications. Divanillin is the homodimer of vanillin and used as a taste enhancer compound and also a promissory anticancer drug. Here, divanillin ...