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The Combination of Vitamin K-3 and Vitamin C Has Synergic Activity against Forms of Trypanosoma cruzi through a Redox Imbalance Process
(Plos One, 2015-12-07) [Artigo]
Chagas' disease is an infection that is caused by the protozoan Trypanosoma cruzi, affecting millions of people worldwide. Because of severe side effects and variable efficacy, the current treatments for Chagas' disease ...
Facile Synthesis and Photophysical Characterization of New Quinoline Dyes
(Journal of Fluorescence, 2017-01-01) [Artigo]
This paper describes the synthesis of new quinoline derivatives, molecules that has been long interest in the organic and medicinal chemistry. Through the Multicomponent Reaction (MCR), an important tool in modern synthetic ...
Oxidation of amino acids by chlorpromazine cation radical and co-catalysis by chlorpromazine
(Pharmacology and Pharmacy, 2012) [Artigo]
The long-tem use of chlorpromazine (CPZ) may cause severe side effects. This property of CPZ might be related to pro-oxidant effects of the chlorpromazine cation radical (CPZ•+), which can be easily generated by catalytic ...
Caffeic Acid Phenethyl Ester: Consequences of Its Hydrophobicity in the Oxidative Functions and Cytokine Release by Leukocytes
(Evidence-based Complementary And Alternative Medicine, 2014-01-01) [Artigo]
Numerous anti-inflammatory properties have been attributed to caffeic acid phenethyl ester (CAPE), an active component of propolis. NADPH oxidases are multienzymatic complexes involved in many inflammatory diseases. Here, ...
The effect of pH on horseradish peroxidase-catalyzed oxidation of melatonin: production of N-1-acetyl-N-2-formyl-5-methoxykynuramine versus radical-mediated degradation
(Journal of Pineal Research, 2007-04-01) [Artigo]
There is a g-rowing body of evidence that melatonin and its oxidation product, N-1-acetyl-N-2-formyl-5-methoxykynuramine (AFMK), have anti-inflammatory properties. From a nutritional point of view, the discovery of melatonin ...
Influence of iron on modulation of the antioxidant system in rat brains exposed to lead
(Environmental Toxicology, 2017-03-01) [Artigo]
The objective of this study was to evaluate markers of oxidative stress in the brains of rats exposed to lead acetate (Pb(C2H3O2)(2)), either associated or not associated with ferrous sulfate (FeSO4). A total of 36 weaning ...
Antiproliferative effect of apocynin in cervical epithelial cells infected by HPV 16 involves change of ROS production and cell cycle
(Medicinal Chemistry Research, 2017-11-01) [Artigo]
The cervical cancer is characterized as a public health problem. The human papillomavirus, especially the high-risk types 16 and 18, is present in 99.7% of cases of invasive cervical cancers. Due to high prevalence, the ...
Albumin-induced circular dichroism in Congo red: applications for studies of amyloid-like fibril aggregates and binding sites
(Spectrochimica Acta. Part A, Molecular And Biomolecular Spectroscopy, 2015-11-05) [Artigo]
Congo red (CR), one of the most commonly used dyes for the identification of amyloid fibril aggregates, is also a ligand of native bovine serum albumin (BSA). Induced circular dichroism (ICD) is a phenomenon observed when ...
Vitamin K3 induces antiproliferative effect in cervical epithelial cells transformed by HPV 16 (SiHa cells) through the increase in reactive oxygen species production
(Archives Of Gynecology And Obstetrics, 2016-10-01) [Artigo]
Cervical cancer is characterized as an important public health problem. According to latest estimates, cancer of the cervix is the fourth most common cancer among women. Due to its high prevalence, the search for new and ...
Oxidative alteration of Trp-214 and Lys-199 in human serum albumin increases binding affinity with phenylbutazone: A combined experimental and computational investigation
(International Journal of Molecular Sciences, 2018-10-01) [Artigo]
Human serum albumin (HSA) is a target for reactive oxygen species (ROS), and alterations of its physiological functions caused by oxidation is a current issue. In this work, the amino-acid residues Trp-214 and Lys-199, ...