Now showing items 21-30 of 60
Solvent-dependent inversion of circular dichroism signal in naproxen: An unusual effect!
(Chirality, 2018-09-01) [Artigo]
The electronic circular dichroism (ECD) spectra of naproxen enantiomers were studied as a function of solvents using experimental (circular dichroism) and theoretical (time-dependent density functional theory) approaches. ...
Investigation of Human Albumin-Induced Circular Dichroism in Dansylglycine
(PLOS ONE, 2013-10-16) [Artigo]
Induced circular dichroism (ICD), or induced chirality, is a phenomenon caused by the fixation of an achiral substance inside a chiral microenvironment, such as the hydrophobic cavities in proteins. Dansylglycine belongs ...
The effect of pyrazinamide and rifampicin on isoniazid metabolism in rats
(Biopharmaceutics & Drug Disposition, 2007-09-01) [Artigo]
Hepatotoxicity is the main concern during tuberculosis chemotherapy with the first-line drugs isoniazid (INH), rifampicin (RMP) and pyrazinamide (PYR). Since these hepatotoxic events have been associated with INH metabolites, ...
The effect of rifampicin and pyrazinamide on isoniazid pharmacokinetics in rats
(Biopharmaceutics & Drug Disposition, 2007-11-01) [Artigo]
Tuberculosis chemotherapy involves combination of the drugs isoniazid (INH), rifampicin (RMP) and pyrazinamide (PYR) for a 6-month period. The present work investigated the influence of RMP and PYR on the pharmacokinetic ...
Serotonin as a physiological substrate for myeloperoxidase and its superoxide-dependent oxidation to cytotoxic tryptamine-4,5-dione
(Biochemical Journal, 2010-01-01) [Resumo]
During inflammatory events, neutrophils and platelets interact to release a variety of mediators. Neutrophils generate superoxide and hydrogen peroxide, and also discharge the haem enzyme myeloperoxidase. Among numerous ...
Identification of the mechanism of action of eupomatenoid-5 isolated from Piper regnellii var. pallescens on Trypanosoma cruzi
(Planta Medica, 2009-07-01) [Resumo]
The effect of pH on horseradish peroxidase-catalyzed oxidation of melatonin: production of N-1-acetyl-N-2-formyl-5-methoxykynuramine versus radical-mediated degradation
(Journal of Pineal Research, 2007-04-01) [Artigo]
There is a g-rowing body of evidence that melatonin and its oxidation product, N-1-acetyl-N-2-formyl-5-methoxykynuramine (AFMK), have anti-inflammatory properties. From a nutritional point of view, the discovery of melatonin ...
Dansylglycine, a fluorescent probe for specific determination of halogenating activity of myeloperoxidase and eosinophil peroxidase
(Analytical Biochemistry, 2017-09-01) [Artigo]
Myeloperoxidase (MPO) and eosinophil peroxidase (EPO) are enzymes present in neutrophil and eosinophil leukocytes, respectively. Here, we present the development of a sensitive and specific assay for determination of the ...
Serum myeloperoxidase level is Increased in heavy smokers
(Open Journal of Clinical Diagnostics, 2013) [Artigo]
Raised myeloperoxidase (MPO) serum levels are associated with endothelial dysfunction and cigarette smoking is a risk factor for cardiovascular diseases. Since myocardial infarction is associated with leukocytosis and ...
Pro-oxidant activity of apocynin radical
(Free Radical Biology and Medicine, 2010-06-15) [Artigo]
Apocynin has been widely used as an NADPH oxidase inhibitor in many experimental models. However, concern regarding the efficacy, selectivity, and oxidative side effects of the inhibitor is increasing. In this study, our ...