Now showing items 31-40 of 61
The reactivity of oytho-methoxy-substituted catechol radicals with sulfhydryl groups: Contribution for the comprehension of the mechanism of inhibition of NADPH oxidase by apocynin
(Biochemical Pharmacology, 2007-08-01) [Artigo]
Redox processes are involved in the mechanism of action of NADPH oxidase inhibitors such as diphenyleneiodonium and apocynin. Here, we studied the structure-activity relationship for apocynin and analogous ortho-methoxy- ...
Light emission from tryptophan oxidation by hypobromous acid
(Luminescence, 2012-10-08) [Artigo]
The emission of ultraweak light from cells is a phenomenon associated with the oxidation of biomolecules by reactive oxygen species. The indole moiety present in tryptophan, serotonin and melatonin is frequently associated ...
Serotonin as a physiological substrate for myeloperoxidase and its superoxide-dependent oxidation to cytotoxic tryptamine-4,5-dione
(Biochemical Journal, 2010-01-01) [Resumo]
During inflammatory events, neutrophils and platelets interact to release a variety of mediators. Neutrophils generate superoxide and hydrogen peroxide, and also discharge the haem enzyme myeloperoxidase. Among numerous ...
Oxidation of melatonin by taurine chloramine
(Journal of Pineal Research, 2010-09-01) [Artigo]
Melatonin is widely known for its antioxidant, immunomodulatory, and anti-inflammatory effects. Hypochlorous acid (HOCl) is one example of an endogenous oxidant that is promptly neutralized by melatonin. Melatonin also ...
Identification of the mechanism of action of eupomatenoid-5 isolated from Piper regnellii var. pallescens on Trypanosoma cruzi
(Planta Medica, 2009-07-01) [Resumo]
Solvent-dependent inversion of circular dichroism signal in naproxen: An unusual effect!
(Chirality, 2018-09-01) [Artigo]
The electronic circular dichroism (ECD) spectra of naproxen enantiomers were studied as a function of solvents using experimental (circular dichroism) and theoretical (time-dependent density functional theory) approaches. ...
Inhibitory effect of gallic acid and its esters on 2,2'-azobis(2-amidinopropane)hodrpchloride (AAPH)-induced hemolysis and depletion of intracellular glutathione in erythrocytes
(Journal of Agricultural and Food Chemistry, 2010) [Artigo]
The protective effect of gallic acid and its esters, methyl, propyl, and lauryl gallate, against 2,2'-azobis(2-amidinopropane)hydrochloride (AAPH)-induced hemolysis and depletion of intracellular glutathione (GSH) in ...
Theoretical-Experimental Photophysical Investigations of the Solvent Effect on the Properties of Green- and Blue-Light-Emitting Quinoline Derivatives
(Journal of Fluorescence, 2017-09-01) [Artigo]
This paper describes the investigations on the solvatochromic effect and the photophysical properties of quinoline derivatives, compounds with potential applicability in optoelectronic devices. Using an experimental and ...
TiO 2 -catalyzed photodegradation of aromatic compounds: relevance of susceptibility to oxidation and electrophilic attack by hydroxyl radical
(Journal of Nanoparticle Research, 2018-12-01) [Artigo]
The application of nanostructured titanium dioxide (TiO 2 ) as catalyst for the photodegradation of drugs and dyes is well established. We aimed to evaluate the importance of the reactivity of aromatic compounds submitted ...
Methyl divanillate: Redox properties and binding affinity with albumin of an antioxidant and potential NADPH oxidase inhibitor
(RSC Advances, 2019-01-01) [Artigo]
Vanillic acid is a widely used food additive (flavouring agent, JECFA number: 959) with many reported beneficial biological effects. The same is true for its ester derivative (methyl vanillate, JECFA number: 159). Based ...