Now showing items 41-50 of 61
Antioxidant effects of quercetin and naringenin are associated with impaired neutrophil microbicidal activity
(Evidence-based Complementary and Alternative Medicine, 2013-08-20) [Artigo]
Naringenin and quercetin are considered antioxidant compounds with promising activity against oxidative damage in human cells. However, no reports have described their effects on reactive oxygen species (ROS) production ...
Enzymatic Antioxidants Analysis and Glutathione in the Brain of Intoxicated Rats by Lead and Supplemented by Iron
(Free Radical Biology and Medicine, 2011-11-01) [Resumo]
The effect of pH on horseradish peroxidase-catalyzed oxidation of melatonin: Production of N1-acetyl-N2-formyl-5- methoxykynuramine versus radical-mediated degradation
(Journal of Pineal Research, 2007-04-01) [Artigo]
There is a growing body of evidence that melatonin and its oxidation product, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK), have anti-inflammatory properties. From a nutritional point of view, the discovery of melatonin ...
Diapocynin versus apocynin as pretranscriptional inhibitors of NADPH oxidase and cytokine production by peripheral blood mononuclear cells
(Biochemical and Biophysical Research Communications, 2010-03-12) [Artigo]
Apocynin has been extensively used as an inhibitor of NADPH oxidase (NOX) in many experimental models using phagocytic and non-phagocytic cells. Currently, there is some controversy about the efficacy of apocynin in ...
2-Bromo-1,4-naphthoquinone: a potentially improved substitute of menadione in Apatone therapy
(Brazilian Journal of Medical and Biological Research, 2012-08-01) [Artigo]
Apatone™, a combination of menadione (2-methyl-1,4-naphthoquinone, VK3) and ascorbic acid (vitamin C, VC) is a new strategy for cancer treatment. Part of its effect on tumor cells is related to the cellular pro-oxidative ...
4-Fluoro-2-methoxyphenol, an apocynin analog with enhanced inhibitory effect on leukocyte oxidant production and phagocytosis
(European Journal of Pharmacology, 2011-06-25) [Artigo]
Apocynin, a methoxy-substituted catechol (4-hydroxy-3-methoxyacetophenone), originally extracted from the roots of Picrorhiza kurroa, has been extensively used as a non-toxic inhibitor of the multienzymatic complex NADPH ...
Oxidation of melatonin by AAPH-derived peroxyl radicals: Evidence of a pro-oxidant effect of melatonin
(Biochimica et Biophysica Acta: General Subjects, 2009-08-01) [Artigo]
Background: Melatonin is well-established as a powerful reducing agent of oxidant generated in the cell medium. We aimed to investigate how readily melatonin is oxidized by peroxyl radicals ROO(-) generated by the thermolysis ...
Optimized synthesis of the melatonin metabolite N(1)-acetyl-N(2)-formyl-5-methoxykynuramine (AFMK)
(Journal of Pineal Research, 2008-10-01) [Artigo]
N(1)-acetyl-N(2)-formyl-5-methoxykynuramine (AFMK) is the product of oxidative pyrrole ring cleavage of melatonin. AFMK and its deformylated derivative N(1)-acetyl-5-methoxykynuramine (AMK) are compounds for which there ...
Alkaloids extracted from Pterogyne nitens induce apoptosis in malignant breast cell line
(Tumor Biology, 2010-10-01) [Artigo]
In the present study, two alkaloids isolated from Pterogyne nitens, a plant native to Brazil, have been shown to induce apoptosis in human breast cancer cells. These compounds, pterogynine (PGN) and pterogynidine (PGD), ...
The oxidation of apocynin catalyzed by myeloperoxidase: Proposal for NADPH oxidase inhibition
(Archives of Biochemistry and Biophysics, 2007-01-15) [Artigo]
Apocynin has been used as an efficient inhibitor of the NADPH oxidase complex and its mechanism of inhibition is linked to prior activation through the action of peroxidascs. Here we studied the oxidation of apocynin ...