Now showing items 51-60 of 60
Neutrophil extracellular traps identification in tegumentary lesions of patients with paracoccidioidomycosis and different patterns of NETs generation in vitro
(Plos Neglected Tropical Diseases, 2015-09-01) [Artigo]
Paracoccidioidomycosis (PCM) is a systemic mycosis, endemic in most Latin American countries, especially in Brazil. It is caused by the thermo-dimorphic fungus of the genus Paracoccidioides (Paracoccidioides brasiliensis ...
Methyl divanillate: Redox properties and binding affinity with albumin of an antioxidant and potential NADPH oxidase inhibitor
(RSC Advances, 2019-01-01) [Artigo]
Vanillic acid is a widely used food additive (flavouring agent, JECFA number: 959) with many reported beneficial biological effects. The same is true for its ester derivative (methyl vanillate, JECFA number: 159). Based ...
Interaction between 1-pyrenesulfonic acid and albumin: Moving inside the protein
(Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2019-02-05) [Artigo]
Due to the high sensitivity to alterations in microenvironment polarity of macromolecules, pyrene and its derivatives have long been applied in biosciences. Human serum albumin (HSA), besides its numerous physiological ...
Oxidative alteration of Trp-214 and Lys-199 in human serum albumin increases binding affinity with phenylbutazone: A combined experimental and computational investigation
(International Journal of Molecular Sciences, 2018-10-01) [Artigo]
Human serum albumin (HSA) is a target for reactive oxygen species (ROS), and alterations of its physiological functions caused by oxidation is a current issue. In this work, the amino-acid residues Trp-214 and Lys-199, ...
TiO 2 -catalyzed photodegradation of aromatic compounds: relevance of susceptibility to oxidation and electrophilic attack by hydroxyl radical
(Journal of Nanoparticle Research, 2018-12-01) [Artigo]
The application of nanostructured titanium dioxide (TiO 2 ) as catalyst for the photodegradation of drugs and dyes is well established. We aimed to evaluate the importance of the reactivity of aromatic compounds submitted ...
Solvent-induced Stokes' shift in DCJTB: Experimental and theoretical results
(Journal Of Molecular Structure, 2019-09-15) [Artigo]
The solvent-induced Stokes' shift, which describes the response at different solvents (acetonitrile, chloroform, dichloromethane, 1,4-dioxane, N,N-dimethylformamide, ethanol, heptanol, tetrahydrofuran, and toluene) to a ...
Inflammatory response of endothelial cells to hepatitis C virus recombinant envelope glycoprotein 2 protein exposure
(Memórias do Instituto Oswaldo Cruz, 2014-09-01) [Artigo]
The hepatitis C virus (HCV) encodes approximately 10 different structural and non-structural proteins, including the envelope glycoprotein 2 (E2). HCV proteins, especially the envelope proteins, bind to cell receptors and ...
Recombinant hepatitis C virus-envelope protein 2 interactions with low-density lipoprotein/CD81 receptors
(Memorias do Instituto Oswaldo Cruz, 2015-06-01) [Artigo]
Hepatitis C virus (HCV) envelope protein 2 (E2) is involved in viral binding to host cells. The aim of this work was to produce recombinant E2B and E2Y HCV proteins in Escherichia coli and Pichia pastoris, respectively, ...
Alkyl caffeates as anti-helicobacter pylori and scavenger of oxidants produced by neutrophils
(Medicinal Chemistry, 2014-02-01) [Artigo]
Helicobacter pylori pathogenic action involves the colonization of the gastrointestinal tract and a large production of reactive oxygen species (ROS) by the neutrophils attracted to the site of infection. The aim of this ...
Identification of the mechanism of action of eupomatenoid-5 isolated from Piper regnellii var. pallescens on Trypanosoma cruzi
(Planta Medica, 2009-07-01) [Resumo]